Oxidative stress is increased in critically ill patients according to antioxidant vitamins intake, independent of severity: a cohort study

Abilés, J.; Cruz, A. Pérez de la; Castaño, José; Rodrı́guez-Elvira, Manuel; Aguayo, Eduardo; Moreno-Torres, Rosario; Llopis, Juan; Aranda, Pilar; Argüelles, Sandro; Ayala, Antonio; Quintana, Alberto Machado de la; Planells, Elena

doi:10.1186/cc5068

Cited by 81 publications

(31 citation statements)

References 38 publications

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“…The growth of oxidative stress index is a concomitant phenomenon of a decrease in the conversion of thyroxine (T 4 ) to triiodothyronine (T 3 ), in particular with nonthyroid illness syndrome (NTIS). This suggests that oxidative stress in this case is not only a sign of the adaptation process but also connected with the state of hypothyroidism (Abilés et al, 2006;Mancini et al, 2016).…”

Section: Discussionmentioning

confidence: 69%

Interdependence of oxidative/antioxidant system indicators and thyroid status under conditions of prolonged exposure to small doses of radiation

Sokolenko¹,

Sokolenko²

2019

Regul. Mech. Biosyst.

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We have studied the interdependence of the intensity of oxidative processes/antioxidant level and the thyroid status parameters in a group of students aged 18–24 who lived for a long time in the territory of enhanced radioecological control (density of soil contamination by isotopes (137Cs 3.7 ∙ 104 – 18.5 ∙ 104 Bq/m2). We examined 50 people from relatively environmentally friendly areas (control group) and 50 people from IV radiation zone (experimental group). In the experimental group, there were no individuals with clinical manifestations of thyroid pathology. However, subgroups with signs of hyperthyroidism and hypothyroidism were identified. We evaluated the level of cortisol, thyrotrophic hormone (TSH), triiodothyronine (T3), thyroxine (T4), malonic dialdehyde (MDA), ceruloplasmin (CP), transferrin (Tf), sulfhydryl groups (SH); we calculated the oxidative stress index (OSI). The research was conducted one month before the examination time and also during the exams as a factor in increased emotional stress. A lowered CP level was found in the subgroup with signs of hypothyroidism; SH groups – in all subgroups, separated by thyroid status. The oxidative stress index was higher in all students examined of the experimental group, compared with the control. The growth of MDA level is marked in the experimental group – it is the most strongly pronounced in conditions of additional emotional load in people with signs of hyperthyroidism and hypothyroidism. CP level significantly decreased in the subgroup of hyperthyroidism on the background of T3 decrease. OSI increased in all students examined from the experimental group. In the subgroup of hypothyroidism it became significantly higher than in the subgroup of euthyroidism. A positive correlation between the levels of CP and T3 was found. The highest values of the correlation coefficients were noted for subgroups with signs of hyperthyroidism and hypothyroidism, with the coefficient significance increasing under conditions of emotional stress. The index of oxidative stress in the experimental group positively correlated with the level of TSH – in terms of emotional stress, the statistical significance of the coefficients disappeared. In the subgroups divided by thyroid status, variability of interactions between OSI and T3 was observed but it was not statistically significant. It was found that the participation of thyroid status in supporting redox homeostasis in people aged 18–24 who suffered from chronic small-doze radiation exposure was realized mainly by the influence on the antioxidant system. The ability of thyroid hormones to maintain a proper antioxidant state was suppressed in this group. The unbalanced relationship between thyroid hormones and oxidative stress indicators is strongly manifested under conditions of additional emotional stress.

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Section: Discussionmentioning

confidence: 69%

Interdependence of oxidative/antioxidant system indicators and thyroid status under conditions of prolonged exposure to small doses of radiation

Sokolenko¹,

Sokolenko²

2019

Regul. Mech. Biosyst.

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“…Even if this replenishment concerns relatively short periods, toxicity [109, 110] is to be kept in mind and appropriate measures should be applied in order to avoid it. In general, the substitution of more than 66% of the recommended daily allowance of vitamins A, C, and E has been shown to improve antioxidant capacity [112]. REDOXS (Reducing Deaths due to Oxidative Stress) study is a blinded randomized trial in 1223 critically ill patients that failed in meeting its original rationale and concluded that the administration of antioxidants and glutamine increased mortality [113].…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress and Acute Kidney Injury in Critical Illness: Pathophysiologic Mechanisms—Biomarkers—Interventions, and Future Perspectives

Pavlakou

Liakopoulos

Eleftheriadis

et al. 2017

Oxidative Medicine and Cellular Longevity

125

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Acute kidney injury (AKI) is a multifactorial entity that occurs in a variety of clinical settings. Although AKI is not a usual reason for intensive care unit (ICU) admission, it often complicates critically ill patients' clinical course requiring renal replacement therapy progressing sometimes to end-stage renal disease and increasing mortality. The causes of AKI in the group of ICU patients are further complicated from damaged metabolic state, systemic inflammation, sepsis, and hemodynamic dysregulations, leading to an imbalance that generates oxidative stress response. Abundant experimental and to a less extent clinical data support the important role of oxidative stress-related mechanisms in the injury phase of AKI. The purpose of this article is to present the main pathophysiologic mechanisms of AKI in ICU patients focusing on the different aspects of oxidative stress generation, the available evidence of interventional measures for AKI prevention, biomarkers used in a clinical setting, and future perspectives in oxidative stress regulation.

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“…New findings from this study include the following: 1) OZ rats have increased tubular injury as compared to LZ rats following trauma; 2) OZ rats have increased renal ROS production following trauma as compared to LZ rats, as well as impaired baseline and posttrauma Increased renal oxidative stress in OZ rats following trauma. Studies have shown that ROS are acutely upregulated in the setting of critical illness, and can have adverse 238 effects on a number of organs(1,18,31,52). However, little work has been done comparing the obese and lean acute oxidative stress responses to critical illness.…”

mentioning

confidence: 99%

Oxidative stress contributes to orthopedic trauma-induced acute kidney injury in obese rats

Mittwede

Xiang

et al. 2015

American Journal of Physiology-Renal Physiology

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After trauma, obese patients have an increased risk of developing acute kidney injury (AKI). We have demonstrated that obese Zucker (OZ) rats, but not lean Zucker (LZ) rats, develop AKI 24 h after orthopedic trauma. ROS have been implicated in the pathophysiology of AKI in models of critical illness. However, the contribution of ROS to trauma-induced AKI in the setting of obesity has not been determined. We hypothesized that AKI in OZ rats after trauma is mediated by increased oxidative stress. Male LZ and OZ rats were divided into control and trauma groups, with a subset receiving treatment after trauma with the antioxidant apocynin (50 mg/kg ip, 2 mM in drinking water). The day after trauma, glomerular filtration rate, plasma creatinine, urine kidney injury molecule-1, and albumin excretion as well as renal oxidant and antioxidant activity were measured. After trauma, compared with LZ rats, OZ rats exhibited a significant decrease in glomerular filtration rate along with significant increases in plasma creatinine and urine kidney injury molecule-1 and albumin excretion. Additionally, oxidative stress was significantly increased in OZ rats, as evidenced by increased renal NADPH oxidase activity and urine lipid peroxidation products (thiobarbituric acid-reactive substances), and OZ rats also had suppressed renal superoxide dismutase activity. Apocynin treatment significantly decreased oxidative stress and AKI in OZ rats but had minimal effects in LZ rats. These results suggest that ROS play an important role in AKI in OZ rats after traumatic injury and that ROS may be a potential future therapeutic target in the obese after trauma.

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Oxidative stress is increased in critically ill patients according to antioxidant vitamins intake, independent of severity: a cohort study

Cited by 81 publications

References 38 publications

Interdependence of oxidative/antioxidant system indicators and thyroid status under conditions of prolonged exposure to small doses of radiation

Interdependence of oxidative/antioxidant system indicators and thyroid status under conditions of prolonged exposure to small doses of radiation

Oxidative Stress and Acute Kidney Injury in Critical Illness: Pathophysiologic Mechanisms—Biomarkers—Interventions, and Future Perspectives

Oxidative stress contributes to orthopedic trauma-induced acute kidney injury in obese rats

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