Oxidative Stress Is Predominant in Female but Not in Male Patients with Autoimmune Thrombocytopenia

Kamhieh-Milz, Julian; Salama, Abdulgabar

doi:10.1155/2014/720347

Cited by 19 publications

(17 citation statements)

References 56 publications

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“…Female genitors appeared more prone to oxidative stress than males with regards to 8-oxodGuo levels in gonad tissue. Sex differences in oxidative stress response have already been observed in humans, with higher sensitivity shown by men or women according to the exposure context (Brunelli et al, 2014;Kamhieh-milz and Salama, 2014). Similar differences have also been observed in fish.…”

Section: Discussionsupporting

confidence: 62%

Parental exposure to the herbicide diuron results in oxidative DNA damage to germinal cells of the Pacific oyster Crassostrea gigas

Barranger

Heude-Berthelin

Rouxel

et al. 2016

Comparative Biochemistry and Physiology Part C: Toxicology &

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Chemical pollution by pesticides has been identified as a possible contributing factor to the massive mortality outbreaks observed in Crassostrea gigas for several years. A previous study demonstrated the vertical transmission of DNA damage by subjecting oyster genitors to the herbicide diuron at environmental concentrations during gametogenesis. This trans-generational effect occurs through damage to genitor-exposed gametes, as measured by the comet-assay. The presence of DNA damage in gametes could be linked to the formation of DNA damage in other germ cells. In order to explore this question, the levels and cell distribution of the oxidized base lesion 8-oxodGuo were studied in the gonads of exposed genitors. High-performance liquid chromatography coupled with UV and electrochemical detection analysis showed an increase in 8-oxodGuo levels in both male and female gonads after exposure to diuron. Immunohistochemistry analysis showed the presence of 8-oxodGuo at all stages of male germ cells, from early to mature stages. Conversely, the oxidized base was only present in early germ cell stages in female gonads. These results indicate that male and female genitors underwent oxidative stress following exposure to diuron, resulting in DNA oxidation in both early germ cells and gametes, such as spermatozoa, which could explain the transmission of diuron-induced DNA damage to offspring. Furthermore, immunostaining of early germ cells seems indicates that damages caused by exposure to diuron on germ line not only affect the current sexual cycle but also could affect future gametogenesis.

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Section: Discussionsupporting

confidence: 62%

Parental exposure to the herbicide diuron results in oxidative DNA damage to germinal cells of the Pacific oyster Crassostrea gigas

Barranger

Heude-Berthelin

Rouxel

et al. 2016

Comparative Biochemistry and Physiology Part C: Toxicology &

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“…A clear difference in gender and oxidative stress could be observed in various diseases, including autoimmune thrombocytopenia (AITP), pancreatic disease, ageing, thyroid disease and some cardiovascular diseases such as CAD. Autoimmune thrombocytopenia is a bleeding disorder, and women with AITP have significantly higher levels of oxidative stress compared to both female controls and males with AITP . This suggests that there is a gender‐specific difference in the pathophysiology of AITP.…”

Section: Gender Oxidative Stress and Diseasesmentioning

confidence: 99%

Gender difference in oxidative stress: a new look at the mechanisms for cardiovascular diseases

Kander

Cui

Liu

2016

J Cellular Molecular Medi

381

238

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Gender differences are present in many diseases and are especially prevalent in cardiovascular disease. Males tend to suffer from myocardial infarctions earlier than females, and a woman's risk of cardiovascular disease increases after menopause, suggesting a cardio‐protective role of estrogen. However, hormone replacement therapy did not decrease the risk of cardiovascular disease in post‐menopausal women; thus, other mechanisms may be involved besides estrogen. Oxidative stress plays an important role in the development of cardiovascular diseases such as coronary artery disease. Gender is also associated with differences in oxidative stress. Under physiological conditions, females appear to be less susceptible to oxidative stress. This may be due to the antioxidant properties of estrogen, gender differences in NADPH‐oxidase activity or other mechanism(s) yet to be defined. This review strives to discuss gender differences in general terms followed by a more detailed examination of gender differences with oxidative stress and various associated diseases and the possible mechanisms underlying these differences.

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“…The threshold of 310 FORT Units was used as high cut-off level of hydroperoxides (17), and a value of 400 FORT Units was employed as very high threshold level of oxidative stress (46). The FORT assays has been validated for clinical use in women and has the advantage to be easily used in outpatient facilities (30,45).…”

Section: Oxidative Stress Assessmentmentioning

confidence: 99%

Increase of Oxidative Stress is Positively Associated with High-Sensitivity C-Reactive Protein in Women Using Combined Oral Contraceptives: An Observational Study

Cauci

Francescato

Colannino

et al. 2020

Preprint

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Background Information concerning oxidative stress and low-grade inflammation in oral contraception users is scarce. We investigated relationships of oxidative stress and high-sensitivity C-reactive protein (hsCRP) in women by oral combined contraceptive (OC) use. Methods Caucasian Italian healthy non-obese women (n = 290; 100 OC-users; 190 non-OC-users; mean age 23.2 ± 4.7 years) were analyzed. Blood hydroperoxides, as oxidative stress biomarkers, were assessed by Free Oxygen Radical Test (FORT), and serum hsCRP was determined by routine methods. Results Oxidative stress levels were elevated (≥ 400 FORT Units) in 77.0% and 15.8% of OC-users and non-OC-users, respectively (odds ratio (OR) = 209, 95%CI = 60.9-715.4, p < 0.001); hsCRP levels ≥ 2.0 mg/L were found in 41.0% and 9.5% of OC-users and non-users, respectively (OR = 6.6, 95%CI 3.5–12.4, p < 0.001). Continuous hydroperoxides values in OC-users were 1.7-fold higher compared to non-users (median 472 versus 270 FORT Units, p < 0.001); OC-users had 3.7-fold higher hsCRP values compared to non-OC-users (median 1.31 versus 0.35 mg/L, p < 0.001). Hydroperoxides were strongly positively correlated to hsCRP in all women (rs=0.622, p < 0.001), in OC-users (rs=0.442, p < 0.001), and in non-OC-users (rs=0.426, p < 0.001). Women with hydroperoxides ≥ 400 FORT Units were 8 times as likely to have hsCRP ≥ 2 mg/L. In non-OC-users only, hydroperoxides values were positively correlated with weight and body mass index, but negatively correlated with red meat, fish and chocolate consumption. Conclusions Our cross-sectional observational study is the first finding a strong positive correlation of serum hydroperoxides with hsCRP, a marker of inflammation. Further research is needed to elucidate the potential role of these two biomarkers in OC-use side-effects, like thromboembolism.

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Oxidative Stress Is Predominant in Female but Not in Male Patients with Autoimmune Thrombocytopenia

Cited by 19 publications

References 56 publications

Parental exposure to the herbicide diuron results in oxidative DNA damage to germinal cells of the Pacific oyster Crassostrea gigas

Parental exposure to the herbicide diuron results in oxidative DNA damage to germinal cells of the Pacific oyster Crassostrea gigas

Gender difference in oxidative stress: a new look at the mechanisms for cardiovascular diseases

Increase of Oxidative Stress is Positively Associated with High-Sensitivity C-Reactive Protein in Women Using Combined Oral Contraceptives: An Observational Study

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