Oxidative Stress Marker Aberrations in Multiple Sclerosis: A Meta-Analysis Study

Abstract

Oxidative stress has been suggested to play a key role in multiple sclerosis (MS), but clinical data on oxidative stress markers in MS patients were inconsistent. This study sought to quantitatively summarize the data of oxidative stress markers in the blood and cerebrospinal fluid (CSF) of patients with MS in the literature. We conducted a systematic search of PubMed and Web of Science and included studies if they provided data on the concentrations of oxidative stress markers in the peripheral blood and CSF of MS patients and healthy control (HC) subjects. The systematic search resulted in the inclusion of 31 studies with 2,001 MS patients and 2,212 HC subjects for meta-analysis. Random-effects meta-analysis demonstrated that patients with MS had significantly increased concentrations of blood oxidative stress markers compared with HC subjects for malondialdehyde (MDA; Hedges' g, 2.252; 95% CI, 1.080 to 3.424; p < 0.001) and lipid hydroperoxide by tert-butyl hydroperoxide-initiated chemiluminescence (CL-LOOH; Hedges' g, 0.383; 95% CI, 0.065 to 0.702; p = 0.018). In contrast, concentrations of albumin (Hedges' g, −1.036; CI, −1.679 to −0.394; p = 0.002) were significantly decreased in MS patients when compared with those in HC subjects. However, the other analyzed blood oxidative stress markers did not show significant differences between cases and controls. Furthermore, this meta-analysis showed significant association between CSF MDA and MS (Hedges' g, 3.275; 95% CI, 0.859 to 5.691; p = 0.008). Taken together, our results revealed increased blood and CSF MDA and decreased blood albumin levels in patients with MS, strengthening the clinical evidence of increased oxidative stress in MS.

Untargeted Metabolomic Profiling of Cuprizone‐Induced Demyelination in Mouse Corpus Callosum by UPLC‐Orbitrap/MS Reveals Potential Metabolic Biomarkers of CNS Demyelination Disorders

“…Notably, reduced cellular energy resulting from CPZ-induced mitochondrial dysfunction can induce oligodendrocyte death [ 36 ]. Furthermore, oxidative stress has been suggested to be one of the main drivers of demyelination and neurodegeneration in MS [ 37 ]. Therefore, blocking oxidative stress during demyelination pathology in MS patients may be a potential therapeutic target.…”

Reduction in Fatigue Symptoms Following the Administration of Nutritional Supplements in Patients with Multiple Sclerosis

“…In addition, we observed an increased serum albumin level in the multivitamin supplemented group, which is in agreement with the reduction in OS. Albumin is a powerful antioxidant with free radical scavenging activity [ 39 ], has a neuroprotective role in neurological diseases [ 40 ], and its level is reduced in MS patients [ 41 ]; therefore, its increase may have contributed to the reduction in OS in the group who received integration. Regarding the involvement of OS on the fatigue symptom in MS, very few reports are present in the literature.…”

Qualitative study identifies life shifts and stress coping strategies in people with multiple sclerosis

“…Regarding depressive symptoms, it was shown that depression is part of the neurological symptoms of MS and that it is primed by peripheral inflammation while an acute neuroinflammation is happening 14 . It was shown by a meta-analysis by Zhang et al 15 that people with MS had significantly increased blood oxitative stress marker levels compared with healthy controls. A systematic review and meta-analysis showed an increased prevalence of depression and anxiety in MS 16 .…”