Oxidative stress markers and micronutrients in maternal and cord blood in relation to neonatal outcome

Weber, Daniela; Stuetz, Wolfgang; Bernhard, Wolfgang; Franz, Axel; Raith, Marco; Grune, Tilman; Breusing, Nicolle

doi:10.1038/ejcn.2013.263

Cited by 106 publications

(99 citation statements)

References 58 publications

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“…One case-control study observed higher levels of MDA in mothers who delivered preterm (N=30) vs. term (N=30), but in another cohort study (N=200) no differences were observed. 25, 26 Importantly, in both studies, blood samples were taken immediately prior to or following delivery.…”

Section: Commentmentioning

confidence: 99%

Repeated measures of urinary oxidative stress biomarkers during pregnancy and preterm birth

Ferguson

McElrath

Chen

et al. 2015

American Journal of Obstetrics and Gynecology

108

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Objective To investigate oxidative stress as a mechanism of preterm birth in human subjects, we examined associations between urinary biomarkers of oxidative stress measured at multiple time points during pregnancy and preterm birth. Study Design This nested case-control study included 130 mothers who delivered preterm and 352 who delivered term who were originally recruited as part of an ongoing prospective birth cohort at Brigham and Women’s Hospital. Two biomarkers, including 8-hydroxydeoxyguanosine (8-OHdG) and 8-isoprostane were measured in urine samples collected at up to four time points (median 10, 18, 26, and 35 weeks) during gestation. Results Urinary concentrations of 8-isoprostane and 8-OHdG decreased and increased, respectively, as pregnancy progressed. Average levels of 8-isoprostane across pregnancy were associated with increased odds of spontaneous preterm birth (adjusted odds ratio [aOR]=6.25, 95% confidence interval [CI]=2.86, 13.7), and associations were strongest with levels measured later in pregnancy. Average levels of 8-OHdG were protective against overall preterm birth (aOR=0.19, 95%CI=0.10, 0.34), and there were no apparent differences in the protective effect in cases of spontaneous preterm birth compared to cases of placental origin. Odds ratios for overall preterm birth were more protective in association with urinary 8-OHdG concentrations measured early in pregnancy. Conclusions Maternal oxidative stress may be an important contributor to preterm birth, regardless of subtype and timing of exposure during pregnancy. The two biomarkers measured in the present study had opposite associations with preterm birth; an improved understanding of what each represents may help to more precisely identify important mechanisms in the pathway to preterm birth.

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Section: Commentmentioning

confidence: 99%

Repeated measures of urinary oxidative stress biomarkers during pregnancy and preterm birth

Ferguson

McElrath

Chen

et al. 2015

American Journal of Obstetrics and Gynecology

108

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“…Malondialdehyde was not detected in liver homogenates of mice fed LAD + Fru, indicating that enhanced lipid peroxidation prevailed in both the SOD-and SOD + Cho-fed groups. While an increase in malondialdehyde can be found in response to relatively mild oxidative stress, oxidized peroxiredoxins (Prx) (26) and protein carbonyls (proteins with oxidized residues such as aldehydes and ketones) (15) are markers for severe oxidative stress. Elevated levels of hyperoxidized peroxiredoxin (Prx-SO 3 ) and protein carbonyl were only detectable in liver homogenates of SOD + Cho-fed mice, not in livers of mice fed SOD without cholesterol or LAD + Fru ( Figure 2B and C).…”

Section: Impact Of Dietary Cholesterol In Soybean Oil Diet On Lipid Pmentioning

confidence: 99%

“…Malondialdehyde was quantified by high-performance liquid chromatography with fluorescence detection in frozen liver tissue homogenized in 50 mM cold phosphate buffer. Briefly, homogenates were derivatized with thiobarbituric acid and further proceeded as described elsewhere (15).…”

Section: Serum and Tissue Analysismentioning

confidence: 99%

Induction of Steatohepatitis (NASH) with Insulin Resistance in Wild-type B6 Mice by a Western-type Diet Containing Soybean Oil and Cholesterol

Henkel

Coleman

Schraplau

et al. 2017

Mol Med

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“…However, the baseline serum retinol levels of the study control and supplemented groups were higher than those found in India [31], Africa, [32,33], and Ethiopia [34] as these countries have high prevalence of vitamin A deficiency, and in Germany [35], probably because of the very different sample size. On the other hand, Yang et al [36] reported a higher level of serum retinol possibly because of different diets of the two samples and sampling methods.…”

Section: Discussionmentioning

confidence: 63%

Maternal Supplementation with <em>RRR</em>-α-Tocopherol (400 IU) and Its Relationship with Serum and Breast Milk Retinol

Dametto¹,

Lira²,

Melo³

et al. 2017

Preprint

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Vitamin A and E are important during pregnancy, the neonatal period, and childhood.The objective of this study was to assess whether maternal RRR-α-tocopherol supplementation affects serum and breast milk retinol. Serum was collected at baseline and twenty days later, and breast milk, at baseline, and on days 1, 7, and 20 after delivery.After the baseline serum collection, the supplemented group (n=16) received a single 400 IU of RRR-α-tocopherol. The control group (n=18) was only performed collections.Retinol and alpha tocopherol levels were determined by liquid chromatography. Serum retinol and alpha tocopherol at baseline and 20 days after delivery indicated proper vitamin A (> 20 µg/dL) and E (> 516 μg/dL) statuses in the control and supplemented groups (p > 0.05). Colostrum retinol levels on days 1 and 7 after delivery were significantly higher in the supplemented group (p = 0.018 and p = 0.012, respectively).Maternal vitamin E supplementation increased colostrum retinol by 52.23% and 111.2%, 24 hours and 7 days, respectively. However, retinol in mature milk did not differ between the groups (p > 0.05). In conclusion, the supplementation with 400 IU of RRR-α-tocopherol improved vitamin A bioavailability in breast milk.

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Oxidative stress markers and micronutrients in maternal and cord blood in relation to neonatal outcome

Abstract: Oxidative stress (elevated PrCarb) was associated with lower BW/head circumference and SGA. Inadequate hemodilution may explain the inverse relation of maternal retinol with BW and head circumference, and the association between highest maternal retinol and risk for SGA.

Cited by 106 publications

References 58 publications

Repeated measures of urinary oxidative stress biomarkers during pregnancy and preterm birth

Repeated measures of urinary oxidative stress biomarkers during pregnancy and preterm birth

Induction of Steatohepatitis (NASH) with Insulin Resistance in Wild-type B6 Mice by a Western-type Diet Containing Soybean Oil and Cholesterol

Maternal Supplementation with <em>RRR</em>-α-Tocopherol (400 IU) and Its Relationship with Serum and Breast Milk Retinol

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Oxidative stress markers and micronutrients in maternal and cord blood in relation to neonatal outcome

Abstract: Oxidative stress (elevated PrCarb) was associated with lower BW/head circumference and SGA. Inadequate hemodilution may explain the inverse relation of maternal retinol with BW and head circumference, and the association between highest maternal retinol and risk for SGA.

Cited by 106 publications

References 58 publications

Repeated measures of urinary oxidative stress biomarkers during pregnancy and preterm birth

Repeated measures of urinary oxidative stress biomarkers during pregnancy and preterm birth

Induction of Steatohepatitis (NASH) with Insulin Resistance in Wild-type B6 Mice by a Western-type Diet Containing Soybean Oil and Cholesterol

Maternal Supplementation with <em>RRR</em>-&alpha;-Tocopherol (400 IU) and Its Relationship with Serum and Breast Milk Retinol

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Product

Resources

About

Maternal Supplementation with <em>RRR</em>-α-Tocopherol (400 IU) and Its Relationship with Serum and Breast Milk Retinol