Oxidative stress markers in affective disorders

Siwek, Marcin; Sowa-Kućma, Magdalena; Dudek, Dominika; Styczeń, Krzysztof; Szewczyk, Bernadeta; Kotarska, Katarzyna; Misztak, Paulina; Pilc, Andrzej; Wolak, Małgorzata; Nowak, Gabriel

doi:10.1016/s1734-1140(13)71517-2

Cited by 125 publications

(82 citation statements)

References 94 publications

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“…This results in the production of free radicals, a high content of lipids (including unsaturated fatty acids) as a substrate for oxidation, an altered redox potential of a number of neurotransmitters, inefficient defense mechanisms against free radicals as well as a high concentration of metal ions (e.g. iron and copper) involved in redox reactions [1,2,4,5,6]. …”

Section: Introductionmentioning

confidence: 99%

“…They have also shown changes in the activity of enzymes involved in the processes of free radical scavenging [6]. According to a meta-analysis, the most frequently observed and most intensified phenomenon which reflects oxidative stress in BD is an increase in thiobarbituric acid-reactive substances (TBARS), which are markers of lipid damage and peroxidation [21].…”

Section: Introductionmentioning

confidence: 99%

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Thiobarbituric Acid-Reactive Substances: Markers of an Acute Episode and a Late Stage of Bipolar Disorder

Siwek

Sowa-Kućma²,

Styczeń³

et al. 2016

Neuropsychobiology

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Background: Lowered antioxidant defense systems and increased oxidative stress are implicated in bipolar disorders (BD). Early and late stages of BD may present different biological features (including the level of oxidative stress) and may therefore require different treatment strategies. The aim of this study was to analyze serum levels of lipid peroxidation [measured as thiobarbituric acid-reactive substances (TBARS), a derivative of malondialdehyde] in BD patients at various stages and phases of the illness and compare their TBARS levels with those of healthy controls. Method: A total of 129 patients (58 in the depressive episode, 23 in the manic episode and 48 in remission) diagnosed with type I (n = 69) or type II (n = 60) BD and 50 healthy volunteers (control group) were enrolled in the study. The level of lipid peroxidation was measured in blood serum using a TBARS assay kit. Results: TBARS levels in the acute episode of mania/hypomania and depression (but not in remission) were significantly higher than in healthy controls. With regard to the BD stage, both early- and late-stage BD TBARS levels were significantly increased in patients in the depressive episode. In late-stage BD, the TBARS level in patients in remission remained elevated compared with controls. A multiple regression model confirmed the association between the TBARS level and BD stage or acute BD. Conclusion: Our findings indicate that TBARS levels reflect the oxidative stress state which increases both in the acute phase of BD (mania/hypomania and depression) and with BD progression (stage).

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Thiobarbituric Acid-Reactive Substances: Markers of an Acute Episode and a Late Stage of Bipolar Disorder

Siwek

Sowa-Kućma²,

Styczeń³

et al. 2016

Neuropsychobiology

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“…It was shown that oxidative and nitrosative stress pathways, along with immune-inflammatory response, might play an important role in the pathogenic mechanisms underlying major depression and bipolar disorder 1 . Reactive oxygen species affect both the immune-inflammatory pathways and the expression of key neurotransmitters which are involved in the pathophysiology of depression 2 .…”

Section: Introductionmentioning

confidence: 99%

Paraoxonase (PON1) L55M and Q192R polymorphisms in major depression and bipolar affective disorder

Yıldız

Celikel

Ateş

et al. 2017

Arch. Clin. Psychiatry (São Paulo)

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Background: Oxidative and nitrosative stress pathways, along with immune-inflammatory response, might play an important role in the pathogenic mechanisms underlying major depression and bipolar disorder. Objective: The aim of the present study is to investigate paraoxonase 1 polymorphisms and its correlations with disease parameters in patients with major depression and bipolar affective disorder. Methods: PON1 L55M and Q192R single nucleotide polymorphisms were analyzed in a group consisted of 100 patients with major depression, and 100 patients with bipolar affective disorder and 96 healthy controls. Polymorphisms were analyzed by using polymerase chain reaction. Results: Our findings reported no association between Q192R and L55M polymorphisms of PON1 and major depression and bipolar disorder. Additionally, there was no association between the PON1 genotypes and disease variables in both depressed and bipolar patients. Discussion: Evaluating the different stages of patients with affective disorders and and investigating the connection between PON1 polymorphisms and treatment outcomes will help us to clarify the relationship between PON1 and mood disorders.

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“…The ROS can damage DNA, proteins, and lipids, and change a cell's metabolism, and affect gene expression and post-translational modifications of proteins, which accelerates ageing, neurodegeneration, and development of atherosclerosis, hypertension, type II diabetes, and cancer [26,27]. Superoxide dismuthase (SOD) and glutathione peroxidase (GPx) are antioxidant enzymes ubiquitous in living organisms acting as an endogenous defense against ROS [28,29].…”

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confidence: 99%