Oxidative Stress Markers in Exhaled Breath Condensate in Lung Fibroses Are Not Significantly Affected by Systemic Diseases

Pelclová, Daniela; Fenclová, Zdeňka; Syslová, Kamila; Vlčková, těpánka; Lebedová, Jindřiška; Pecha, Ondřej; Běláček, Jaromír; Navrátil, Tomá; Kuzma, Marek; Kačer, Petr

doi:10.2486/indhealth.ms1237

Cited by 21 publications

(14 citation statements)

References 16 publications

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“…58 A study performed in individuals with silicosis and other pulmonary diseases showed increased levels of MDA in silicosis, including correlation with radiological severity. 59 On the other hand, in coherence with the data from our present study, a recent study performed in workers exposed to silica from ceramics in Turkey showed increased serum MDA and decreased SOD levels associated with silica exposure (with and without silicosis) in comparison to the nonexposed controls. 60 These discordant results may be related to exposure factors such as particle size distribution, exposure intensity, and duration of exposure, as well as the duration and severity of the disease.…”

supporting

confidence: 92%

“…Besides an increased activity of SOD, glutathione peroxidase and catalase were also observed in coal workers with pneumoconiosis when compared to a control group 58 . A study performed in individuals with silicosis and other pulmonary diseases showed increased levels of MDA in silicosis, including correlation with radiological severity 59 . On the other hand, in coherence with the data from our present study, a recent study performed in workers exposed to silica from ceramics in Turkey showed increased serum MDA and decreased SOD levels associated with silica exposure (with and without silicosis) in comparison to the nonexposed controls 60 .…”

Section: Discussionmentioning

confidence: 90%

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Inflammatory and oxidative stress biomarkers induced by silica exposure in crystal craftsmen

Carneiro

Algranti

Chérot‐Kornobis

et al. 2020

American J Industrial Med

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Background Identification of biomarkers associated with the diagnosis and prognosis of silicosis would be highly advantageous in the clinical setting. The aim of this study is to evaluate inflammatory and oxidative stress biomarkers in subjects exposed to silica. Methods A cross‐sectional study of crystal craftsmen currently (n = 34) or formerly (n = 35) exposed and a group of nonexposed subjects (n = 12) was performed. Personal respirable dust samples were collected. Plasma inflammatory mediators (bone morphogenetic protein‐ BMP2 and chemokines CXCL16, and CCL5), oxidative stress enzymes (thiobarbituric acid reactive substances [TBARs] and superoxide dismutase [SOD]), and nitrite (NO2−) were analyzed in parallel with nitric oxide in exhaled breath (FeNO). Results Being currently or formerly exposed to silica was related to increased levels of CXCL16 and TBARs. Currently, exposed subjects showed decreased levels of SOD. Thirty‐seven craftsmen with silicosis (26 formerly and 11 currently exposed) showed higher levels of CXCL16, which was positively associated with the radiological severity of silicosis. Compared with the nonexposed, subjects with silicosis had higher levels of TBARs and those with complicated silicosis had lower levels of SOD. In multivariate analysis, higher levels of CXCL16 were associated with exposure status and radiological severity of silicosis. Smoking was not a confounder. FeNO did not distinguish between the exposure status and the presence of silicosis. Conclusion CXCL16 emerged as a potential biomarker that could distinguish both silica exposure and silicosis. TBARs were elevated in exposed individuals. However, their clinical applications demand further investigation in follow‐up studies of representative samples.

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supporting

confidence: 92%

Section: Discussionmentioning

confidence: 90%

Inflammatory and oxidative stress biomarkers induced by silica exposure in crystal craftsmen

Carneiro

Algranti

Chérot‐Kornobis

et al. 2020

American J Industrial Med

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“…Further studies are needed to elucidate any possible relationships. The measurement of markers in EBC is not commonly used in the practice of occupational medicine; nevertheless the results support its utility as a noninvasive technique for exploring the pathophysiology of lung diseases due to asbestos 32) and silica 33) . EBC collection and analysis is not considered a standard method for the medical practice yet, however repeated findings in groups of different subjects with pneumoconiosis support its usefulness.…”

Section: Discussionmentioning

confidence: 89%

Leukotrienes B4, C4, D4 and E4 in the Exhaled Breath Condensate (EBC), Blood and Urine in Patients with Pneumoconiosis

Pelclová¹,

Fenclová²,

Vlčková³

et al. 2012

Ind Health

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Leukotrienes (LTs) are involved in the pathogenesis of lung fibrosis and were increased in exhaled breath condensate (EBC) of the patients with pneumoconiosis. However the possible influence of extra-pulmonary disorders on the EBC markers is not known. Therefore in parallel with EBC, LTs' levels in the plasma and urine were measured in patients with pneumoconiosis (45 × asbestos exposure, 37 × silica exposure) and in 27 controls. Individual LTs B4, C4, D4 and E4 were measured by liquid chromatography − electrospray ionization − tandem mass spectrometry (LC-ESI-MS/MS). In EBC, LT D4 and LT E4 were increased in both groups of patients (p<0.001 and p<0.05), comparing with the controls. Both LT B4 and cysteinyl LTs were elevated in asbestosexposed subjects (p<0.05). Asbestosis with more severe radiological signs (s1/s2-t3/u2) and lung functions impairment has shown higher cysteinyl LTs and LT C4 in the EBC (p<0.05) than mild asbestosis (s1/s0-s1/s1). In addition, in the subjects with asbestosis, cysteinyl LTs in EBC correlated with TLC (−0.313, p<0.05) and TLCO/Hb (−0.307, p<0.05), and LT C4 with TLC (−0.358, p<0.05). In pneumoconioses, EBC appears the most useful from the 3 fluids studied.

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“…Another sample type to examine oxidative stress in the lungs of IPF patients is exhaled breath condensate which can be evaluated to obtain information on the lungs in situ and for a variety of respiratory diseases on a trial basis [26]. It was also reported that oxidative stress measurement with exhaled breath condensate was unaffected by systemic diseases [27]. However, like the report by Daniil et al [11], the above studies performed single measurement in each patient.…”

Section: Discussionmentioning

confidence: 93%

Change in serum marker of oxidative stress in the progression of idiopathic pulmonary fibrosis

Mori¹,

Kawashima²,

Kuwabara³

et al. 2015

Pulmonary Pharmacology & Therapeutics

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Oxidative Stress Markers in Exhaled Breath Condensate in Lung Fibroses Are Not Significantly Affected by Systemic Diseases

Cited by 21 publications

References 16 publications

Inflammatory and oxidative stress biomarkers induced by silica exposure in crystal craftsmen

Inflammatory and oxidative stress biomarkers induced by silica exposure in crystal craftsmen

Leukotrienes B4, C4, D4 and E4 in the Exhaled Breath Condensate (EBC), Blood and Urine in Patients with Pneumoconiosis

Change in serum marker of oxidative stress in the progression of idiopathic pulmonary fibrosis

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