Oxidative stress measurement by in vivo electron spin resonance spectroscopy in rats with streptozotocin-induced diabetes

Sano, Tetsuro; Umeda, Fumio; Hashimoto, Toshihiko; Nawata, Hajime; Utsumi, Hideo

doi:10.1007/s001250051076

Cited by 186 publications

(124 citation statements)

References 31 publications

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“…In addition, increased oxidative stress (26) and vascular alterations [decreased microvascular blood flow, increased vascular resistance, and altered vascular permeability (27,28)] are believed to lead to functional (decreased nerve conduction velocity and nerve blood flow) and structural abnormalities (29,30). In particular, in STZ-diabetic rats, there are evidences of apoptosis of dorsal root ganglia sensory neurons and Schwann cells (31), possibly due to oxidative stress driven by hyperglycemia (32,33). Our prior work has shown that EPO prevents neuronal apoptosis in vitro in hypoxic neurons and in vivo in cerebral ischemia in rats (7).…”

Section: Discussionmentioning

confidence: 99%

Erythropoietin both protects from and reverses experimental diabetic neuropathy

Bianchi

Büyükakıllı

Brines

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

238

179

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Tail-nerve conduction velocities (NCV) was assessed at 5 and 11 weeks for the preventive and therapeutic schedule, respectively. Compared to nondiabetic rats, NCV was 20% lower after 5 weeks in the STZ group, and this decrease was attenuated 50% by rhEPO. Furthermore, the reduction of Na ؉ ,K ؉ -ATPase activity of diabetic nerves (by 55%) was limited to 24% in the rhEPO-treated group. In the therapeutic schedule, NCV was reduced by 50% after 11 weeks but by only 23% in the rhEPO-treated group. rhEPO treatment attenuated the decrease in compound muscle action potential in diabetic rats. In addition, rhEPO treatment was associated with a preservation of footpad cutaneous innervation, as assessed by protein gene product 9.5 immunostaining. Diabetic rats developed alterations in mechanical and thermal nociception, which were partially reversed by rhEPO given either in a preventative or therapeutic manner. These observations suggest that administration of rhEPO or its analogues may be useful in the treatment of diabetic neuropathy.

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Section: Discussionmentioning

confidence: 99%

Erythropoietin both protects from and reverses experimental diabetic neuropathy

Bianchi

Büyükakıllı

Brines

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

238

179

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“…40) Previous animal studies show that persistent hyperglycemia causes increased production of reactive oxygen species through glucose autooxidation and NEG, which in turn causes increased oxidative stress. 41) GSH, the most important biomolecule against chemically induced toxicity, can participate in the elimination of reactive intermediates by reduction of hydroperoxides in the presence of GP x . 42) GSH also functions as a free radical scavenger and in the repair of radical-caused biological damage.…”

Section: Discussionmentioning

confidence: 99%

Effects of Chard (Beta vulgarisL. var cicla) on the Liver of the Diabetic Rats: A Morphological and Biochemical Study

Saçan

Karabulut-Bulan

Bolkent

et al. 2004

Bioscience, Biotechnology, and Biochemistry

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“…However, (Inoguchi et al, 2000;Sano et al, 1998;Oberley, 1988). This leads to the formation of PN with an array of biological actions contributing to impairment of endothelial function.…”

Section: Introductionmentioning

confidence: 99%