Oxidative stress-mediated genotoxicity of wastewaters collected from two different stations in northern India

Tabrez, Shams; Ahmad, Masood

doi:10.1016/j.mrgentox.2011.07.012

Cited by 44 publications

(23 citation statements)

References 49 publications

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“…The heavy metals (Cr, Mn, Fe, Co, Ni, Cu and Zn) accumulated in these tissues are all potentially redox active suggesting an imbalance between production of ROS and their neutralization, and bearing fish is said to be under the influence of oxidative stress. This imbalance may lead to damage of tissues and cellular components, which in turn would trigger induction of antioxidant defense mechanisms 30, 31 . Hence, SOD, CAT, GST and GSH can serve as sensitive biomarkers of environmental pollution in aquatic organisms.…”

Section: Resultsmentioning

confidence: 99%

Multiple biomarker responses (serum biochemistry, oxidative stress, genotoxicity and histopathology) in Channa punctatus exposed to heavy metal loaded waste water

Javed

Usmani

Ahmad

2017

Sci Rep

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156

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Experiments were conducted to investigate the health of fish Channa punctatus inhabiting heavy metal-loaded waste water. Heavy metals in the order of Fe > Mn > Zn > Co > Ni > Cu = Cr were present in the waste water. Gills had high metal load followed by liver and then kidney. Albumin, albumin to globulin (A:G) ratio, triglyceride, high density lipoprotein (HDL) and very low density lipoprotein (VLDL) were found to be lower but phospholipid, low density lipoprotein (LDL), total protein, lipid and cholesterol were higher as compared to the reference. Oxidative stress markers such as superoxide dismutase (SOD), catalase (CAT), glutathione S transferase (GST) and lipid peroxidation (LPO) were significantly higher in all tissues, whereas reduced glutathione (GSH) levels were comparatively low. Damage to DNA was observed with significantly higher mean tail length of comets in the exposed fish gill cells (30.9 µm) followed by liver (24.3 µm) and kidney (20.6 µm) as compared to reference fish (5.2, 4.8 and 5.9 µm respectively). Histopathology in gill, liver and kidney also showed marked damage. Integrated biochemical, oxidative stress, genotoxicity and histopathological findings are valuable biomarkers for native fish adaptive patterns, and monitoring of water quality/pollution of freshwater ecosystems.

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Section: Resultsmentioning

confidence: 99%

Multiple biomarker responses (serum biochemistry, oxidative stress, genotoxicity and histopathology) in Channa punctatus exposed to heavy metal loaded waste water

Javed

Usmani

Ahmad

2017

Sci Rep

Self Cite

156

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“…Genotoxic testing of complex industrial effluents has demonstrated the presence of many unidentified and unregulated toxicants that are potential carcinogens. This has raised concern associated with their release into the water bodies (Houk 1992;Claxton et al 1998;Tabrez and Ahmad 2011). The standard chemical analysis of the water samples can rarely provide an adequate assessment of the genotoxicity potential of complex mixture present in surface water (Ohe et al 2004).…”

Section: Introductionmentioning

confidence: 99%

“…There are number of reports suggesting the correlation between pollution level and mutagenicity (Hubert et al 2012). A number of animal, bacterial and plant-based assays have been developed for the estimation of mutagenic and genotoxic potential of water samples (Vargas et al 1995;Tabrez and Ahmad 2011). The in vivo toxicity analysis using small mammals is a very long and expensive procedure, hence some in vitro analysis for routine evaluation of genotoxicity of water has been recommended.…”

Section: Introductionmentioning

confidence: 99%

Water quality monitoring of an international wetland at Harike, Punjab and its impact on biological systems

et al. 2015

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The present study entails the investigation of mutagenic and genotoxic effect of surface water samples collected from 13 different sites of the Harike wetland using the histidine reversion point mutation assay in Salmonella typhimurium (TA98) strain and plasmid nicking assay using pBR322, respectively. The physicochemical characterization of water samples using different parameters was conducted for water quality monitoring. Heavy metal analysis was performed to quantify the toxic components present in water samples. It was observed that although the water samples of all the sites demonstrated mutagenic as well as genotoxic activity, the effect was quite significant with the water samples from sites containing water from river Satluj, i.e., site 1 (upstream Satluj river), site 2 (Satluj river) and site 3 (reservoir Satluj). The high level of pollution due to industrial effluents and agricultural run-off at these sites may engender the genotoxicity and mutagenicity of water samples.

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“…have been involved in bioremediation of various pollutants such as phenols, benzoate, crude oil, acetonitrile etc 1, 2. and biotechnological applications like production of extra-and-intracellular lipases, proteases, bio-emulsifiers and various types of biopolymers 3, 4.…”

Section: Genome Announcementmentioning

confidence: 99%

Draft genome sequence of phenol degrading Acinetobacter sp. Strain V2, isolated from oil contaminated soil

Sharma

Lin

2017

Brazilian Journal of Microbiology

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We report here the draft genome sequence of Acinetobacter sp. Strain V2 isolated from the oil contaminated soil collected from ENGEN, Amanzimtoti, South Africa. Degradation of phenolic compounds such as phenol, toluene, aniline etc. at 400 ppm in 24 h and oil degrading capability makes this organism an efficient multifunctional bioremediator. Genome sequencing of Acinetobacter spp. V2 was carried out on Illumina HiSeq 2000 platform (performed by the Beijing Genomics Institute [BGI], Shenzhen, China). The data obtained revealed 643 contigs with genome size of 4.0 Mb and G + C content of 38.59%.

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Oxidative stress-mediated genotoxicity of wastewaters collected from two different stations in northern India

Cited by 44 publications

References 49 publications

Multiple biomarker responses (serum biochemistry, oxidative stress, genotoxicity and histopathology) in Channa punctatus exposed to heavy metal loaded waste water

Multiple biomarker responses (serum biochemistry, oxidative stress, genotoxicity and histopathology) in Channa punctatus exposed to heavy metal loaded waste water

Water quality monitoring of an international wetland at Harike, Punjab and its impact on biological systems

Draft genome sequence of phenol degrading Acinetobacter sp. Strain V2, isolated from oil contaminated soil

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