Oxidative stress: New insights on the association of non-alcoholic fatty liver disease and atherosclerosis

Polimeni, Licia; Ben, Maria Del; Baratta, Francesco; Perri, Ludovica; Albanese, Fabiana; Pastori, Daniele; Violi, Francesco; Angelico, Francesco

doi:10.4254/wjh.v7.i10.1325

Cited by 174 publications

(150 citation statements)

References 134 publications

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“…SH3BP5 is necessary for JNK-mediated induction of lipotoxicity and nonalcoholic steatohepatitis (NASH) [39], both of which are thought to closely correlate with atherosclerosis, as suggested by the involvement of common mediators such as macrophages, nuclear factor (erythroidderived 2)-like 2, and oxidative stress [40][41][42]. Notably, the detected BTK-binding region of SH3BP5 was located within amino acids 163-193 [37], which overlaps with bSH3BP5-161, a peptide of SH3BP5 consisting of amino acids 161-174.…”

Section: Discussionmentioning

confidence: 99%

Serum SH3BP5-specific Antibody Level is a Biomarker of Atherosclerosis

Hiwasa¹,

Tomiyoshi²,

Nakamura³

et al. 2017

Immunome Res

214

179

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Background: The discovery and development of novel biomarkers that could facilitate early diagnosis and thus prevent the progression of atherosclerosis-related diabetes mellitus (DM), cerebral infarction (CI), and cardiovascular disease (CVD) has garnered much research interest. Notably, recent reports have described a number of highly sensitive antibody markers. In this study, we aimed to identify additional antibody markers that would facilitate screening. Methods:The amplified luminescent proximity homogeneous assay (AlphaLISA) method, which incorporates glutathione-or streptavidin-donor beads and anti-human-IgG-acceptor beads, was used to evaluate serum antibody levels in serum samples. The protein array method was used for the initial screening, and peptide arrays were used to identify epitope sites. Results:The protein array identified SH3 domain-binding protein 5 (SH3BP5) as a target antigen of serum IgG antibodies in the sera of patients with atherosclerosis. We prepared recombinant glutathione S-transferase (GST)-fused SH3BP5 protein. Peptide arrays revealed that the epitope site recognized by serum antibodies is located within amino acids 161-174 of SH3BP5. AlphaLISA revealed significantly higher serum antibody levels against both the SH3BP5 protein and peptide in patients with DM, acute-phase CI, transient ischemic attack, CVD or chronic kidney disease (CKD), than in healthy donors. Furthermore, areas under the receiver operating characteristic curves of these antibodies were higher in patients with CKD and DM than in other patients. Spearman correlation analysis revealed associations between the serum antibody levels against SH3BP5 peptide and artery stenosis, hypertension, and smoking. Conclusions:The serum anti-SH3BP5 antibody marker appears to be useful for estimating the progress of atherosclerosis and may discriminate atherosclerosis associated with hypertension and/or habitual smoking.

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Section: Discussionmentioning

confidence: 99%

Serum SH3BP5-specific Antibody Level is a Biomarker of Atherosclerosis

Hiwasa¹,

Tomiyoshi²,

Nakamura³

et al. 2017

Immunome Res

214

179

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“…Interestingly, total polyphenol content and antiradical activity in ancient khorasan were not quantitatively different from those of the control modern wheat, even if previous studies reported only slight but significantly higher levels of total polyphenol secondary metabolites, only when compared to control modern soft wheat. Nonetheless, given that the generation of ROS can induce lipid peroxidation leading to inflammation, as well as hepatic insulin resistance, and is involved in all stages of atherosclerotic plaque formation (16), the significant decrease in ROS-derived blood cells is similarly a repeatable characteristic of ancient khorasan wheat. The liver function enzymes ALT, AST, and ALP, an indirect measure of inflammation, decreased significantly only after consumption of the ancient khorasan products.…”

Section: Liver Steatosis Grading and Doppler Ultrasound Examinationmentioning

confidence: 99%

“…Overall, a 10% improvement was evident in the khorasan group and a 5% improvement in the control group, with no significant differences between groups. Discussion NAFLD, considered the hepatic manifestation of the metabolic syndrome, is an emerging liver disease warranting extensive research (16). Clinical dietary trials on patients with NAFLD are scarce (2), and to the best of our knowledge, no trials have yet been performed assessing the efficacy of cereals on NAFLD patients.…”

Section: Liver Steatosis Grading and Doppler Ultrasound Examinationmentioning

confidence: 99%

A Khorasan Wheat-Based Replacement Diet Improves Risk Profile of Patients With Nonalcoholic Fatty Liver Disease (NAFLD): A Randomized Clinical Trial

Dinu

Whittaker

Pagliai

et al. 2018

Journal of the American College of Nutrition

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Objective: KAMUT khorasan is an ancient grain with widely acclaimed health benefits. The aim of this study was to investigate the effects of a replacement diet with ancient khorasan wheat products in patients with NAFLD, in comparison to a similar replacement diet with control products made from organic semi-whole-grain modern wheat. Methods: Forty NAFLD patients (12 M/28 F; age 55.2 § 10.4 years) with mild to moderate liver steatosis were included. The experimental design was a randomized, double-blind, parallel-arm study with 20 participants assigned to consume either KAMUT khorasan or control wheat products (pasta, bread, crackers, biscuits) over a 3-month period. Anthropometric measurements, blood analyses, and ultrasonography examination were performed at both the beginning and end of each dietary intervention. Results: After the implementation of a general linear model for repeated measurements adjusted for baseline demographic details, risk factors, and medication, alanine aminotransferase (ALT) was significantly reduced by 12%, aspartate aminotransferase (AST) by 14%, alkaline phosphatase (ALP) by 8%, and cholesterol by 6% only in the khorasan group (p < 0.05 for all). Similarly, significant reductions in circulating proinflammatory tumor necrosis factor-alpha by 50%, interleukin l-receptor antagonist-alpha by 37%, interleukin-8 by 24%, and interferon gamma by 24% were evident only in participants who consumed the khorasan products (p < 0.05 for all). Finally, significant improvements in the liver steatosis grading, Doppler perfusion index values, and reactive oxygen species (ROS) production were evident after consumption of both the khorasan and control products. Conclusions: This study suggests that a short-term replacement diet with ancient KAMUT khorasan products is most effective in reducing metabolic risk factors and ameliorating the liver profile in patients with NAFLD.

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“…NAFLD represents a wide spectrum of diseases, ranging from simple steatosis to steatosis with inflammation to cirrhosis. Although simple hepatic steatosis is a slowly developing asymptomatic disease, the next stage, non-alcoholic steatohepatitis (NASH), is more likely to cause progressive cirrhosis and hepatocellular carcinoma, resulting in increased mortality [69]. It seems that chronic stress is directly linked to NAFLD and chronic inflammation in visceral fat [70].…”

Section: Muscle Mass: Myosteatosis and Sarcopeniamentioning

confidence: 99%

Chronic stress and body composition disorders: implications for health and disease

Stefanaki

Pervanidou

Boschiero³

et al. 2018

Hormones

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Recent studies have suggested that body composition is key to health and disease. First, fat tissue is a complex, essential, and highly active metabolic and endocrine organ that responds to afferent signals from traditional hormone systems and the central nervous system but also expresses and secretes factors with important endocrine, metabolic, and immune functions. Second, skeletal muscle mass is an important predictor of health in adult life, while severe mass loss has been associated with the frailty of old age. Studies have shown that skeletal muscle is also an important endocrine organ that secretes factors with autocrine, paracrine, or endocrine actions, which have been associated with inflammatory processes. Third, the bone is also a systemic endocrine regulator playing a pivotal role in health and disease. Finally, proper hydration in humans has been neglected as a health factor, especially in adults. Chronic stress and stress hormone hypersecretion alone or associated with distinct disorders, such as anxiety, depression, obesity, metabolic syndrome, autoimmune disorders, type 2 diabetes mellitus, and polycystic ovary syndrome (PCOS), have been associated with psychological and somatic manifestations, typically, increased fat mass, osteosarcopenia/frailty, cellular dehydration, and chronic systemic inflammation. This review aims to provide new insights into the newly developed concept of stress-related osteosarcopenic obesity and its prevention.

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Oxidative stress: New insights on the association of non-alcoholic fatty liver disease and atherosclerosis

Cited by 174 publications

References 134 publications

Serum SH3BP5-specific Antibody Level is a Biomarker of Atherosclerosis

Serum SH3BP5-specific Antibody Level is a Biomarker of Atherosclerosis

A Khorasan Wheat-Based Replacement Diet Improves Risk Profile of Patients With Nonalcoholic Fatty Liver Disease (NAFLD): A Randomized Clinical Trial

Chronic stress and body composition disorders: implications for health and disease

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