Oxidative stress parameters in patients with prostate cancer, benign prostatic hyperplasia and asymptomatic inflammatory prostatitis: A prospective controlled study

Kaya, Engin; Özgök, Yaşar; Zor, Murat; Eken, Ayşe; Bedir, Selahattin; Erdem, Onur; Ebiloğlu, Turgay; Ergin, Giray

doi:10.17219/acem/66837

Cited by 27 publications

(29 citation statements)

References 34 publications

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“…The reason cited for the depletion of the antioxidant enzymes, such as CAT, SOD, and GSH, in BPH has been the accumulation of superoxide anion radicals and hydrogen peroxide (Özten‐Kandaş & Bosland, ). Improving antioxidant status in patients improved clinical signs of BPH (Kaya et al, ; Udensi & Tchounwou, ). Malondialdehyde is produced as a stable product of the free radical peroxidation of cellular organelles.…”

Section: Discussionmentioning

confidence: 99%

“…The etiology of BPH has not been entirely detected. Different factors, including inflammatory mediators, hormones, and oxidative stress, may have a role in the development of BPH (Kaya et al, ). Oxidative stress has been found to be among the mechanisms which activate the factors involved in the development and progression of prostatic hyperplasia (Pace et al, ).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Changes in the oxidative stress factors and inflammatory proteins following the treatment of BPH‐induced dogs with an anti‐proliferative agent called tadalafil

Dearakhshandeh

Mogheiseh

Nazifi

et al. 2019

Vet Pharm & Therapeutics

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Background Finding a medical treatment which can combat cell proliferation and relax smooth muscles in canine benign prostatic hyperplasia (BPH) appears to be imperative. Aims This study aimed to evaluate the oxidative stress and inflammatory proteins following the treatment of dogs induced for BPH with an anti‐proliferative agent called tadalafil. Materials and Methods Twenty‐five adult intact male dogs were randomly designated into five groups (n = 5): Control group was not induced for BPH and not treated with tadalafil; dogs induced for BPH by testosterone enanthate and estradiol benzoate and treated with tadalafil (5 mg/day P.O.); dogs which received tadalafil (5 mg/day P.O.); dogs induced for BPH and treated with castration; and dogs induced for BPH. Oxidative stress factors (glutathione peroxidase [GPX], superoxide dismutase [SOD], catalase) and inflammatory proteins (haptoglobin, serum amyloid A [SAA], malondialdehyde [MDA]) were measured in the blood serum for four sequential weeks. Results Glutathione peroxidase and SOD serum levels declined in dogs in the BPH‐induced group compared to those in the control group. Those levels diminished in BPH‐induced castrated and tadalafil‐treated groups. The changes in the GPX and SOD serum concentrations were not significant between the BPH‐induced castrated group and BPH‐induced tadalafil‐treated group. Moreover, MDA concentration increased slightly in groups with BPH and groups which were castrated. Generally, however, there were no significant differences in the MDA serum concentrations between other groups. Haptoglobin and SAA concentrations increased in BPH‐castrated group. Also, the differences in haptoglobin and SAA were not significant between the groups. Conclusion Tadalafil could not control oxidative stress and inflammatory mediators which happened during BPH in dogs.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Changes in the oxidative stress factors and inflammatory proteins following the treatment of BPH‐induced dogs with an anti‐proliferative agent called tadalafil

Dearakhshandeh

Mogheiseh

Nazifi

et al. 2019

Vet Pharm & Therapeutics

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“…Our interest in this topic was reinforced by a number of recent studies which, besides pointing to an increase in risk of developing prostate cancer in men with a history of chronic prostatitis, demonstrated that oxidative stress is associated with the development and progression of prostate cancer. 18 – 27 …”

Section: Introductionmentioning

confidence: 99%

“… 122 Due to its properties, curcumin can play a very important role, especially in consideration of newly acquired knowledge indicating that chronic prostatitis favors the development of prostate cancer. 18 – 25 , 27 …”

Section: Introductionmentioning

confidence: 99%

Inflammatory mechanisms and oxidative stress in prostatitis: the possible role of antioxidant therapy

Paulis¹

2018

RRU

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This article focuses on the role that oxidative stress plays in chronic prostatitis, not only with respect to the known impact on symptoms and fertility but also especially in relation to possible prostate cancer development. Prostatitis is the most common urologic disease in adult males younger than 50 years and the third most common urologic diagnosis in males older than 50 years. If the germ-causing acute prostatitis is not eliminated, the inflammatory process becomes chronic. Persistent inflammation causes ongoing production of large quantities of pro-inflammatory cytokines and both oxygen and nitrogen reactive species, with consequent activation of transcription factor nuclear factor-kappa B (NF-κB) and genes encoding for further production of pro-inflammatory cytokines, chemotactic factors, and growth factors. Confirming the role of oxidative stress in chronic prostatitis, several studies have demonstrated the presence of oxidative stress markers in the genital secretions of patients suffering from the disease. Antioxidants can therefore play an essential role in the treatment of chronic bacterial and non-bacterial prostatitis; in the case of bacterial inflammation, they can be associated with antibiotic therapy. Moreover, due to their anti-inflammatory properties, antioxidants hinder the progression of inflammation and the possible development of prostate cancer.

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Potential role of glutathione S-transferase P1 gene polymorphism and metabolic syndrome in lower urinary tract symptoms attributed to benign prostatic hyperplasia

Zhang

Miao

et al. 2021

World J Urol

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Oxidative stress parameters in patients with prostate cancer, benign prostatic hyperplasia and asymptomatic inflammatory prostatitis: A prospective controlled study

Cited by 27 publications

References 34 publications

Changes in the oxidative stress factors and inflammatory proteins following the treatment of BPH‐induced dogs with an anti‐proliferative agent called tadalafil

Changes in the oxidative stress factors and inflammatory proteins following the treatment of BPH‐induced dogs with an anti‐proliferative agent called tadalafil

Inflammatory mechanisms and oxidative stress in prostatitis: the possible role of antioxidant therapy

Potential role of glutathione S-transferase P1 gene polymorphism and metabolic syndrome in lower urinary tract symptoms attributed to benign prostatic hyperplasia

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