Oxidative stress parameters in patients with ascending aortic dilatation

Abstract

Background/aim: This study aimed to determine plasma thiol, disulphide, and serum ischemia-modified albumin (IMA) levels and ferroxidase activity in patients with ascending aorta dilatation (AAD) in comparison to those without AAD and to evaluate the predictive value of these oxidative stress parameters for AAD. Materials and methods: This study was designed as a cross-sectional study of 184 patients who applied to our cardiology clinic. Our study population consisted of patients with AAD (n = 85) and without AAD (n = 99). A spectrophotometric method was used to determine plasma thiol, disulphide, and serum IMA levels and ferroxidase activity. Results: The native thiol and the total thiol levels were significantly higher in the control group than the AAD group (P < 0.001), whereas the disulphide and IMA levels and the ferroxidase activity were similar between the groups. The native thiol and the total thiol levels were inversely and significantly correlated with ascending aortic diameter (r =-0.38, P < 0.001; r =-0.39, P < 0.001; respectively). The left ventricle mass and the total thiol levels were independent predictors of ascending aortic diameter (β= 0.223, P = 0.02; β=-0.340, P < 0.001; respectively). Conclusion: Among oxidative stress parameters including thiols, disulphide, IMA, and ferroxidase activity, only the lower total thiol levels appear to confer a high risk for AAD development. Along with the proven diagnostic imaging methods, thiol levels may be helpful to diagnose and stratify patients with AAD.

Oxidative Stress Parameters as Biomarkers of Cardiovascular Disease towards the Development and Progression

“…Further analysis revealed the association of TTL with fatal MI risk. However, Erdoğan and colleagues (2020) highlighted a different finding in which higher levels of TTL were shown in the control group than in the ascending aortic dilatation (AAD) group [ 39 ]. Lower TTL appears to confer a higher risk for AAD development and independently predicts the diameter of ascending aortic.…”

Investigation of the correlation between cardiac parameters and aortic diameter in patients with ascending aortic aneurysm

“…In aortic dissection patients, it was previously found that aortic diameter is related with cardiac hypertrophy, and in the same study, marked correlation was found between aortic diameter and left ventricle mass index (LVMI) [ 15 ]. Similarly, Erdogan et al found a statistical relationship between LVMI and ascending aorta size, whereas on the other hand, they found significant difference between patients with dilated ascending aorta and normal populations, in regards to LVDd, LVPWd, LVEF, and LAD [ 16 ]. Similarly, a significant relationship was reported by Iarussi et al between aortic diameter and cardiac parameters, such as LVDd, LVDs and LVMI index, in an analysis of aortic dissection patients [ 17 ].…”

Asendan aort dilatasyonunda oksidatif stres ile ilişkili belirteçlerin rolü: malondialdehit ve paraoksonaz-1 aktivitesi

“…Previous studies have found that oxidative stress plays a leading role in the development of aortic aneurysms (2)(3)(4). The remodeling of the aortic wall is substantially associated with an impaired balance between MMP and its inhibitors (4)(5)(6).…”

“…As it is a clinically silent entity, one of the main reasons for mortality in adults is an ascending aortic aneurysm (AscAA) (1). Familial predisposition, hemodynamic force, aortic transmural inflammation, destructive remodeling, and oxidative stress in the extracellular matrix have contributed to the pathophysiology of AAD (2)(3)(4).…”