Oxidative stress pathway genes and chronic renal insufficiency in Asian Indians with Type 2 diabetes

Tiwari, Arun K.; Prasad, Priyanka; Thelma, B.K.; Kumar, K M Prasanna; Ammini, AC; Gupta, Arvind; Gupta, Rajeev

doi:10.1016/j.jdiacomp.2007.10.003

Cited by 69 publications

(62 citation statements)

References 49 publications

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“…Recent studies have indicated that the SOD1-251 A/G polymorphism is associated with reduced antioxidant capacity [52,53]. Therefore, our findings indicate that individuals with impaired antioxidant activity may have a predisposition to diseases associated with oxidative stress.…”

Section: Discussionsupporting

confidence: 50%

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The role of Cat -262C/T, GPX1 Pro198Leu and Sod1+35A/C gene polymorphisms in a development of primary open-angle glaucoma in a Polish population

Malinowska¹,

Kowalski²,

Szaflik³

et al. 2016

pjp

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The development of glaucoma may be connected with a long-term exposure to oxidative stress caused by free radical (ROS). The main aim of this work was an analysis of associations of Cat-262C/T, GPX1 Pro198Leu and SOD1 35 A/C gene polymorphisms of antioxidant enzymes with a risk of open-angle glaucoma (POAG) in a Polish population. DNA samples collected from 209 patients with POAG and 191 healthy controls were used in this study. Polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). We found that the +35A/C polymorphisms of SOD1 were not associated with a risk of POAG. We found that C/T genotype (1-GPX1Pro198Leu, 2-Cat C262T) is associated with increased risk of open angle glaucoma (1-OR = 2.24; 95% CI: 1.46-3.44; p = 0.0001, 2-OR = 2.16; 95% CI: 1.35-3.34; p = 0.001). We also found that T/T genotype is a risk factor for progression of POAG (1-OR = 3.86; 95% Cl: 1.36-10.96; p = 0.007, 2-OR = 6.37; 95% CI: 1.39-29.28; p = 0.007). Finally our data suggest that gene polymorphisms of GPX1 Pro198Leu and CAT C262T may have a protective role in the development of primary open-angle glaucoma in a Polish population.

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Section: Discussionsupporting

confidence: 50%

“…The Pro198Leu polymorphisms can significantly influence the levels and activity of most common antioxidant enzymes, which can lead to reduced protection against oxidative stress [17,18,19,20,21].…”

Section: Introductionmentioning

confidence: 99%

The role of Cat -262C/T, GPX1 Pro198Leu and Sod1+35A/C gene polymorphisms in a development of primary open-angle glaucoma in a Polish population

Malinowska¹,

Kowalski²,

Szaflik³

et al. 2016

pjp

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“…Only in 2 studies, HbA 1c level was significantly lower in the DN groups, 17,18 and in 2 studies duration of diabetes was significantly shorter in the DN groups. 21,19 Meta-analysis results GSTM1 For DN risk and the null genotype of GSTM1, our meta-analysis gave a statistically significant overall OR of 1.27 (95% CI, 1.02-1,58; P = 0.03) with statistically nonsignificant between-study heterogeneity (P heterogeneity = 0.13, I 2 = 37.8%; FIGURE 2). This analysis is based on pooling of data from a number of different ethnic populations and both type 1 and type 2 diabetes.…”

Section: Discussionmentioning

confidence: 77%

Effects of genetic polymorphisms of glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) on the risk of diabetic nephropathy: a meta-analysis

Orlewski¹,

Orlewska²

2015

Polish Archives of Internal Medicine

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“…The Ile105Val polymorphism alone or in combination with the smoking status was not found to affect the risk of type 2 diabetes mellitus or risk of cardiovascular events in diabetic patients, but it was found to be associated with chronic renal insufficiency (19)(20)(21)(22).…”

Section: Discussionmentioning

confidence: 92%

GSTP1 Ile105Val Polymorphism in Serbian Patients with Pancreatic Diseases

Nikolić¹,

Stanković²,

Nišević³

et al. 2011

Journal of Medical Biochemistry

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Kratak sadr`aj: Cilj ove studije bio je da se odredi u~e stalost polimorfizma Ile105Val u genu za glutation S-trans ferazu P1 (GSTP1) i proceni njegov uticaj na rizik za obolevanje od pankreasnih bolesti u srpskoj populaciji. Studija je obuhvatila 157 pacijenata sa naj~e{}im bolestima pankreasa: 47 sa karcinomom pankreasa, 50 sa hroni~nim pankre atitisom i 60 sa dijabetes melitusom tipa 2, kao i 107 zdravih ispitanika. Prisustvo polimorfizma Ile105Val u genu za GSTP1 je analizirano metodom PCR-RFLP (Polymerase Chain Reaction -Restriction Fragment Length Polymorphism). U~estalost alela 105Val je bila ni`a kod pacijenata sa karcinomom pankreasa (24,5%) i hroni~nim pankreatitisom (24,0%) i neznatno povi{ena kod pacijenata sa dijabe tes melitusom tipa 2 (31,7%) u odnosu na u~estalost kod zdra vih ispitanika (29,9%), ali razlike nisu bile statisti~ki zna ~aj ne. U~estalost pojedinih genotipova polimorfizma Ile105Val se razlikovala me|u analiziranim grupama, ali razlike tako|e nisu bile statisti~ki zna~ajne. Samo nekoliko studija se do sada bavilo ulogom GSTP1 Ile105Val poli morfizma u bole stima pankreasa i uglavnom su dale opre ~ne rezultate. Zna ~aj GSTP1 Ile105Val polimorfizma za bolesti pankreasa jo{ uvek nije razja{njen i potrebna su da lja istra`iva nja da bi se ispitala njegova uloga u pankreas nom tkivu.Klju~ne re~i: glutation S-transferaza P1 (GSTP1), polimor fizam Ile105Val, karcinom pankreasa, hroni~ni pankreatitis, dijabetes melitus tipa 2

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Oxidative stress pathway genes and chronic renal insufficiency in Asian Indians with Type 2 diabetes

Cited by 69 publications

References 49 publications

The role of Cat -262C/T, GPX1 Pro198Leu and Sod1+35A/C gene polymorphisms in a development of primary open-angle glaucoma in a Polish population

The role of Cat -262C/T, GPX1 Pro198Leu and Sod1+35A/C gene polymorphisms in a development of primary open-angle glaucoma in a Polish population

Effects of genetic polymorphisms of glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) on the risk of diabetic nephropathy: a meta-analysis

GSTP1 Ile105Val Polymorphism in Serbian Patients with Pancreatic Diseases

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