Oxidative stress profile in the post-operative patients with biliary atresia

Asakawa, Tomohiro; Tanaka, Yoshiaki; Asagiri, Kimio; Kobayashi, Hiroharu; Tanikawa, Ken; Yagi, Minoru

doi:10.1007/s00383-008-2284-8

Cited by 16 publications

(14 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Early-stage BA is associated with augmented oxidative DNA, mtDNA damage, and a decrease in mitochondrial copy number relative to that observed in late-stage BA. Our study was in accordance with Asakawa's which described that postoperative patients with BA were under increased oxidative stress [ 17 ]. Our report also proved that the oxidative stress increased more in BA before Kasai operation than after the operation and both are higher than the normal control [ 2 ].…”

Section: Discussionsupporting

confidence: 91%

“…To our knowledge, no study has evaluated the benefit of liver transplantation (LT) in BA patients in terms of oxidants/antioxidants. Our hypothesis is that if antioxidant levels are increased after LT [ 2 , 10 , 16 , 17 ], then the administration of antioxidants is needed in those cases who hesitate to receive LT or in cases where a liver graft is not available from donors. Therefore, our aim was to study the oxidative status in children with BA by examining the malondialdehyde (MDA) and antioxidant enzyme levels as well as mitochondrial copy numbers.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Characteristics of Antioxidant Activity after Liver Transplantation in Biliary Atresia Patients

Chen

Tang

Huang

et al. 2015

BioMed Research International

View full text Add to dashboard Cite

Purpose. Cholestatic liver injury is associated with a high production of free radicals. The pathogenesis of liver injury in biliary atresia (BA) patients is largely undefined. The goal of the present study was to clarify the oxidative damage and the changes in antioxidant enzyme activities that occur during the development of BA and after liver transplantation (LT). Methods. We enrolled BA patients and control subjects and collected their clinical information. The activities of antioxidant enzymes in BA patients before LT (BA group) and after LT (LT group) were analyzed. Results. The number of mitochondrial DNA copies had increased in the LT group compared with the BA group. Similarly, the activity of glutathione peroxidase had increased in the LT group compared with the BA group. The level of glutathione was higher in the LT group than in the BA group. Malondialdehyde levels were decreased in the LT group compared with the BA group. Conclusions. These data indicate that LT is associated with increased antioxidant enzyme activities and decreased malondialdehyde levels in BA patients. The manipulation of mitochondria-associated antioxidative activity might be an important future management strategy for BA.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

The Characteristics of Antioxidant Activity after Liver Transplantation in Biliary Atresia Patients

Chen

Tang

Huang

et al. 2015

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…active oxygen species caused by chronic inflammation may lead to tissue injury and disease progression (17). In many BA patients, Kasai's hepatic portoenterostomy fails to resolve upregulation of oxidative stress, even in cases of mild liver dysfunction without jaundice (18). The aforementioned finding suggests that antioxidant therapy may be necessary for the treatment of BA patients.…”

Section: Discussionmentioning

confidence: 99%

Antifibrotic potential of bone marrow‑derived mesenchymal stem cells in biliary atresia mice

et al. 2018

View full text Add to dashboard Cite

Biliary atresia (BA) is a rare and severe disease that affects infants where a fibroinflammatory process destroys the bile ducts, leading to fibrosis and biliary cirrhosis, and mortality if untreated. Bone marrow‑derived mesenchymal stem cells (BMMSCs) have been considered as a promising therapy in fibrotic diseases. The aim of the present was to investigate the anti‑fibrotic roles of BMMSC transplantation in a BA mouse model. Mouse BA models were established by Rhesus rotavirus administration to neonatal mice. The results revealed that the liver enzyme and bilirubin metabolism levels, and the levels of the oxidative stress marker malondialdehyde (MDA) and the fibrosis marker were all increased in the BA model, while the liver tissue levels of superoxide dismutase and glutathione peroxidase were reduced. The hematoxylin and eosin and Masson's trichrome staining revealed severe liver fibrosis and collagen accumulation in BA livers. However, these indicators were all reversed once the BA mice were administered the BMMSC inoculation. In conclusion, the present study demonstrated the anti‑fibrotic potential of BMMSCs in BA mice, which may provide a novel approach to ameliorate the fibrotic response in BA patients.

show abstract

“…We have previously reported that postoperative patients with BA were under severe oxidative stress, even with mild liver dysfunction without jaundice [13,21]. Oxidative stress results in the progression of cholestatic disease, while antioxidant therapy reduces cholestasis [13].…”

Section: Nt-group×40 T-group×40mentioning

confidence: 99%

The herbal medicine Inchinko-to reduces hepatic fibrosis in cholestatic rats

et al. 2011

Self Cite

View full text Add to dashboard Cite

show abstract

Oxidative stress profile in the post-operative patients with biliary atresia

Abstract: The post-operative patients with BA were under increased oxidative stress, even if their liver dysfunction was mild without jaundice. Antioxidant therapy might be necessary to decrease of oxidative stress in the post-operative patients with BA.

Cited by 16 publications

References 14 publications

The Characteristics of Antioxidant Activity after Liver Transplantation in Biliary Atresia Patients

The Characteristics of Antioxidant Activity after Liver Transplantation in Biliary Atresia Patients

Antifibrotic potential of bone marrow‑derived mesenchymal stem cells in biliary atresia mice

The herbal medicine Inchinko-to reduces hepatic fibrosis in cholestatic rats

Contact Info

Product

Resources

About