Oxidative Stress Reactions in Women of Reproductive Age with Metabolic Syndrome

Darenskaya, M. A.; Belenkaya, L. V.; Atalyan, A. V.; Danusevich, I. N.; Лазарева, Л. М.; Nadeliaeva, Iana; Колесникова, Л. И.

doi:10.1007/s10517-023-05754-w

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…OS is one of the key mechanisms in the development of many disorders [ 19 , 20 , 21 , 22 , 23 , 24 ], just as disturbances of the gut microbiome are associated with many and diverse human disease processes [ 13 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 48 , 49 , 50 , 51 ]. The OS–microbiome interaction might be relevant to understanding and correcting various conditions.…”

Section: Discussionmentioning

confidence: 99%

“…The antioxidant mechanisms (specific enzymes or combined biochemical processes) prevent cell damage and restore oxidative homeostasis [ 16 , 17 , 18 ]. OS is associated with many different diseases [ 19 , 20 , 21 , 22 , 23 , 24 ]; however, there are many gaps in our understanding of the mechanisms under normal and pathological conditions since the casual association between OS and the microbiome has drawn attention only recently. Revealing the mechanisms underlying the gut microbiome and OS interactions may pave the way for developing novel therapeutic strategies for different disorders.…”

Section: Introductionmentioning

confidence: 99%

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Gut Microbiome Interactions with Oxidative Stress: Mechanisms and Consequences for Health

Semenova,

Garashchenko,

Kolesnikov

et al. 2024

Pathophysiology

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Understanding how gut flora interacts with oxidative stress has been the subject of significant research in recent years. There is much evidence demonstrating the existence of the microbiome–oxidative stress interaction. However, the biochemical basis of this interaction is still unclear. In this narrative review, possible pathways of the gut microbiota and oxidative stress interaction are presented, among which genetic underpinnings play an important role. Trimethylamine-N-oxide, mitochondria, short-chain fatty acids, and melatonin also appear to play roles. Moreover, the relationship between oxidative stress and the gut microbiome in obesity, metabolic syndrome, chronic ethanol consumption, dietary supplements, and medications is considered. An investigation of the correlation between bacterial community features and OS parameter changes under normal and pathological conditions might provide information for the determination of new research methods. Furthermore, such research could contribute to establishing a foundation for determining the linkers in the microbiome–OS association.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gut Microbiome Interactions with Oxidative Stress: Mechanisms and Consequences for Health

Semenova,

Garashchenko,

Kolesnikov

et al. 2024

Pathophysiology

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Metabolic Syndrome in Reproductive Age Women of Various Ethnic Groups. Neuroendocrine Status and Lipid Peroxidation System

Belenkaya,

Darenskaya,

Kolesnikov

et al. 2024

Bull Exp Biol Med

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Age-related determinants of the metabolic syndrome in women of reproductive age of the main ethnic groups of the Baikal Region

Belenkaia,

Suturina,

Darenskaya

et al. 2023

Acta biomedica scientifica

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The aim of the study. To determine the age limit of the initial manifestations of the metabolic syndrome in women of reproductive age of the Caucasian and Asian ethnic groups. Materials and methods. The study included women of reproductive age of the Russian and Buryat ethnic groups (n = 1231). We carried out general clinical examination, studied glycemia levels and lipid metabolism indicators. The analysis of the components of the metabolic syndrome was performed taking into account age characteristics and ethnicity. Threshold values for the age of metabolic disorders manifestation were determined. Results. It was found that the main components of the metabolic syndrome in women of reproductive age of the Russian and Buryat ethnic groups were a decrease in high-density lipoprotein (HDL), an increase in waist circumference, and an increase in blood pressure. The age-related determinants of the metabolic syndrome in the population of women of reproductive age in the Baikal region were determined. It was shown that the age-related determinants of the metabolic syndrome in Caucasian and Asian women do not differ significantly and amount to 33.5 years (95% confidence interval (95% CI): 32.5; 38.5) and 36.5 years (95% CI: 27.5; 52.5), respectively. A universal critical age value was determined as 34.5 years (95% CI: 32.5; 38.5), which is associated with a significant increase in the prevalence of the metabolic syndrome in accordance with the ATP III criteria. The ranking of metabolic syndrome criteria in the studied groups revealed the following order of their occurrence: the decrease in HDL index prevailed, followed by the increase in waist circumference, blood pressure, glucose and triglycerides; no dependence on the ethnicity was found. Conclusion. When assessing the age-related determinants of the metabolic syndrome in the mixed Caucasoid-Asian group, it is advisable to use universal approaches, taking into account the cut-off point of age, which is 34.5 years. The determination of age criteria for the correct classification of patients with respect to the manifestations of the metabolic syndrome is necessary to analyze the contribution of the age factor to the implementation of various metabolic syndrome predictors, to develop prognostic models, and to use effective age-determined markers of metabolic disorders.

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Oxidative Stress Reactions in Women of Reproductive Age with Metabolic Syndrome

Cited by 3 publications

References 9 publications

Gut Microbiome Interactions with Oxidative Stress: Mechanisms and Consequences for Health

Gut Microbiome Interactions with Oxidative Stress: Mechanisms and Consequences for Health

Metabolic Syndrome in Reproductive Age Women of Various Ethnic Groups. Neuroendocrine Status and Lipid Peroxidation System

Age-related determinants of the metabolic syndrome in women of reproductive age of the main ethnic groups of the Baikal Region

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