Oxidative Stress, Reductive Stress and Antioxidants in Vascular Pathogenesis and Aging

Mladenov, Mitko; Lubomirov, Lubomir T.; Grisk, Olaf; Avtanski, Dimiter; Mitrokhin, Vadim; Sazdova, Iliyana; Keremidarska-Markova, Milena; Danailova, Yana; Georgiev, G.; Konakchieva, Rossitza; Gagov, Hristo

doi:10.3390/antiox12051126

Cited by 22 publications

(6 citation statements)

References 243 publications

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“…The intricate relationship between hydrogen sulfide (H 2 S) and oxidative stress is an area of extensive interest in molecular biology, biochemistry, and medicine [ 63 ]. Oxidative stress, characterized by an imbalance between the generation of reactive oxygen species (ROS) and the ability of the biological system to detoxify these reactive intermediates, has significant implications for cellular function, tissue integrity, and the pathogenesis of numerous diseases [ 64 , 65 ].…”

Section: Resultsmentioning

confidence: 99%

Hydrogen Sulfide: An Emerging Regulator of Oxidative Stress and Cellular Homeostasis—A Comprehensive One-Year Review

Munteanu,

Turnea,

Rotariu

2023

Antioxidants

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Hydrogen sulfide (H2S), traditionally recognized as a toxic gas, has emerged as a critical regulator in many biological processes, including oxidative stress and cellular homeostasis. This review presents an exhaustive overview of the current understanding of H2S and its multifaceted role in mammalian cellular functioning and oxidative stress management. We delve into the biological sources and function of H2S, mechanisms underlying oxidative stress and cellular homeostasis, and the intricate relationships between these processes. We explore evidence from recent experimental and clinical studies, unraveling the intricate biochemical and molecular mechanisms dictating H2S’s roles in modulating oxidative stress responses and maintaining cellular homeostasis. The clinical implications and therapeutic potential of H2S in conditions characterized by oxidative stress dysregulation and disrupted homeostasis are discussed, highlighting the emerging significance of H2S in health and disease. Finally, this review underscores current challenges, controversies, and future directions in the field, emphasizing the need for further research to harness H2S’s potential as a therapeutic agent for diseases associated with oxidative stress and homeostatic imbalance. Through this review, we aim to emphasize H2S’s pivotal role in cellular function, encouraging further exploration into this burgeoning area of research.

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Section: Resultsmentioning

confidence: 99%

Hydrogen Sulfide: An Emerging Regulator of Oxidative Stress and Cellular Homeostasis—A Comprehensive One-Year Review

Munteanu,

Turnea,

Rotariu

2023

Antioxidants

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“…New experimental evidence suggests that flavonoids such as baicalin, cyanidin, quercetin, and luteolin can reduce allergy reactions by balancing the Th17/Treg ratio and increasing the number of regulatory T cells (Tregs) [ 231 , 232 ]. Similarly, curcumin reduced Th17 cell differentiation and increased Treg subtype numbers in a mouse asthma model, suggesting a modulatory impact on the Th17/Treg imbalance [ 233 , 234 , 235 ].…”

Section: Possible Modes Of Action For Treating or Preventing Allergy-...mentioning

confidence: 99%

Dietary Polyphenols, Plant Metabolites, and Allergic Disorders: A Comprehensive Review

Farhan,

Rizvi,

Aatif

et al. 2024

Pharmaceuticals

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Given the ongoing rise in the occurrence of allergic disorders, alterations in dietary patterns have been proposed as a possible factor contributing to the emergence and progression of these conditions. Currently, there is a significant focus on the development of dietary therapies that utilize natural compounds possessing anti-allergy properties. Dietary polyphenols and plant metabolites have been intensively researched due to their well-documented anti-inflammatory, antioxidant, and immunomodulatory characteristics, making them one of the most prominent natural bioactive chemicals. This study seeks to discuss the in-depth mechanisms by which these molecules may exert anti-allergic effects, namely through their capacity to diminish the allergenicity of proteins, modulate immune responses, and modify the composition of the gut microbiota. However, further investigation is required to fully understand these effects. This paper examines the existing evidence from experimental and clinical studies that supports the idea that different polyphenols, such as catechins, resveratrol, curcumin, quercetin, and others, can reduce allergic inflammation, relieve symptoms of food allergy, asthma, atopic dermatitis, and allergic rhinitis, and prevent the progression of the allergic immune response. In summary, dietary polyphenols and plant metabolites possess significant anti-allergic properties and can be utilized for developing both preventative and therapeutic strategies for targeting allergic conditions. The paper also discusses the constraints in investigating and broad usage of polyphenols, as well as potential avenues for future research.

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“…The electron's flow through the ETC is an imperfect process, that leads to an incomplete reduction in the oxygen by mitochondria and to the production of ROS [46]. ROS include free radicals, such as superoxide anion (O2•−) and hydroxyl radical (HO•), and non-radicals, such as hydrogen peroxide (H2O2) [47]. It has been shown that the interaction between hydroxyl radicals and DNA causes damage on multiple sites of the DNA itself [48].…”

Section: Mitochondrial Dysfunction and Rosmentioning

confidence: 99%

Oxidative Stress in Obstructive Sleep Apnea Syndrome: Putative Pathways to Hearing System Impairment

et al. 2023

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Introduction: OSAS is a disease that affects 2% of men and 4% of women of middle age. It is a major health public problem because untreated OSAS could lead to cardiovascular, metabolic, and cerebrovascular complications. The more accepted theory relates to oxidative stress due to intermittent hypoxia, which leads, after an intense inflammatory response through multiple pathways, to endothelial damage. The objective of this study is to demonstrate a correlation between OSAS and hearing loss, the effect of the CPAP on hearing function, and if oxidative stress is also involved in the damaging of the hearing system. Methods: A review of the literature has been executed. Eight articles have been found, where seven were about the correlation between OSAS and the hearing system, and only one was about the CPAP effects. It is noted that two of the eight articles explored the theory of oxidative stress due to intermittent hypoxia. Results: All studies showed a significant correlation between OSAS and hearing function (p < 0.05).Conclusions: Untreated OSAS affects the hearing system at multiple levels. Oxidative stress due to intermittent hypoxia is the main pathogenetic mechanism of damage. CPAP has no effects (positive or negative) on hearing function. More studies are needed, with the evaluation of extended high frequencies, the execution of vocal audiometry in noisy environments, and the evaluation of potential biomarkers due to oxidative stress.

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Oxidative Stress, Reductive Stress and Antioxidants in Vascular Pathogenesis and Aging

Cited by 22 publications

References 243 publications

Hydrogen Sulfide: An Emerging Regulator of Oxidative Stress and Cellular Homeostasis—A Comprehensive One-Year Review

Hydrogen Sulfide: An Emerging Regulator of Oxidative Stress and Cellular Homeostasis—A Comprehensive One-Year Review

Dietary Polyphenols, Plant Metabolites, and Allergic Disorders: A Comprehensive Review

Oxidative Stress in Obstructive Sleep Apnea Syndrome: Putative Pathways to Hearing System Impairment

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