Oxidative stress-related liver dysfunction by sodium arsenite: Alleviation by<i>Pistacia lentiscus</i>oil

Klibet, Fahima; Boumendjel, Amel; Khiari, Mohamed; Feki, Abdelfattah El; Abdennour, Cherif; Messarah, Mahfoud

doi:10.3109/13880209.2015.1043562

Cited by 31 publications

(23 citation statements)

References 75 publications

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“…The significant reduction in RBC and Hb is probably due to the effect of the free radicals generated by nitrate on the red cells when certain free radicals, as O 2 .- and OH, are very reactive species able to cause membrane lipid damage. Moreover, in the presence of strong concentrations of these radicals, haemoglobin can easily oxidised 41 , 42 . Furthermore, PSO co-administration in rats' was found to keep the investigated parameters within their physiological ranges.…”

Section: Discussionmentioning

confidence: 99%

“…The latter is subsequently converted into nontoxic water and oxygen molecules by the action of CAT 48 . Nevertheless, GPx plays a pivotal role in H 2 O 2 catabolism and GST acts a key role in cellular detoxification 41 , 49 . It was found that small deviations in physiological concentrations may have dramatic effects on the resistance of cellular lipids, proteins and DNA to oxidative damage 49 .…”

Section: Discussionmentioning

confidence: 99%

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Pumpkin seed oil alleviates oxidative stress and liver damage induced by sodium nitrate in adult rats: biochemical and histological approach

et al. 2020

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Background: Nitrate (NO3) is the most common chemical contaminant in the world’s ground water aquifer. Oxidative stress has been proposed as a possible mechanism involved in NO3 toxicity on non-target organism. Objectives: The current study aimed to elucidate the potential protective effect of Telfairia occidentalis (pumpkin seed oil, PSO) against hepatotoxicity induced by sodium nitrate. Methods: Wistar rats were exposed either to NaNO3 (200 mg/kg bw) in drinking water in drinking water, or to 4ml PSO/kg bw by gavage or to their combination. Oxidative stress parameters, biochemical biomarkers and liver histopathological examination were determined. Results: Our data showed that the exposure of rats to NaNO3 caused significant changes of some haematological parameters compared to the control. In addition, there was a significant elevation of the levels of biochemical markers as that of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and lactate dehydrogenase when compared with the control. Furthermore, exposure of rats to NaNO3 induced liver oxidative stress as indicated by the increase of malondialdehyde, pro- gressive oxidation of protein products and protein carbonyl levels. In addition, a reduction in anti-oxidant status (catalase, glutathione peroxidase, glutathione-S-transferase and superoxide dismutase, reduced glutathione and vitamin C) was observed. Conclusion: Co-administration of PSO to the NaNO3 restored most parameters cited above to near-normal values. Therefore, the present investigation revealed the ability of PSO to attenuate NaNO3-induced oxidative damage. Keywords: Sodium nitrate; Telfairia occidentalis; pumpkin seed oil; hepatotoxicity; oxidative stress; protection; anti-oxidant status, rat.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pumpkin seed oil alleviates oxidative stress and liver damage induced by sodium nitrate in adult rats: biochemical and histological approach

et al. 2020

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“…5 Arsenic metabolism in the liver generates reactive oxygen species (ROS) which include dimethyl arsenic peroxyl ([(CH 3 ) 2 AsOO]) and dimethyl arsenic radical [(CH 3 ) 2 As]. [6][7][8][9] These reactions are catalysed by a cytosolic enzyme, methyltransferase, which uses S-adenosyl methionine (SAM, also known as S-adenosyl-L-methionine) as a methyl group donor. 10 The methylated arsenic intermediates can be more toxic than inorganic arsenate (As V ) or arsenite (As III ), which means under certain circumstances methylation activity can exacerbate arsenic toxicity.…”

Section: Introductionmentioning

confidence: 99%

The role of molecular modelling strategies in validating the effects of chrysin on sodium arsenite-induced chromosomal and DNA damage

et al. 2018

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Chrysin (CHR) is a food-based bioactive ingredient whereas, sodium arsenite (SA) is one of the major contaminant in drinking water. When ingested, SA contributes to tissue damage due to bioactivation by S-adenosyl methionine (SAM)-dependent methyltransferase. Hence, the needs to nullify this effect by investigating the potentials of CHR on SA-induced genotoxicity in rats. The experiment was divided into two successive stages (ameliorative and preventive, curative studies) for 1 week. Rats were divided into four groups: distilled water, 10mg/kg SA, 10mg/kg CHR and co-administration. In stage 2, the experimental groups were given either CHR or SA for 1 week, and treated in reversed order for additional week. Lipid peroxidation, protein carbonyl and DNA fragmentation in liver, blood brain and bone marrow cells micronucleus were assayed for using standard protocols. Molecular docking of SAM-dependent methyltransferase in the presence of CHR was conducted. CHR significantly ( p < 0.05) decreased the level of lipid peroxidation, protein carbonyls and DNA fragmentation in blood, liver and brain tissues as against group treated with SA. It also significantly ( p<0.05) reduced the level of micronuclei generated in bone marrow cells. The effects of CHR were shown to be ameliorative, preventive and curative in nature. Furthermore, CHR was able to dock (with binding energy of -24.81 kcal/mol and predicted inhibition kinetic constant (Ki) of 0.959 µM) into the active site of SAM-dependent methyltransferase with strong hydrogen bond and hydrophobic interactions. The study might have unravelled the potentials of CHR against SA-induced chromosomal and DNA damage, which might be due to inhibition of SAM-dependent methyltransferase.

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“…Though the antioxidants were found to be useful, the mechanism was not clear. It is possible that the antioxidants (vitamin E and C) could play a role in reducing cellular oxidative stress produced by arsenic [24,25,26,27]. Vitamin A (Retinol) has the antikeratinizing effect and used as chemoprevention against some cancer particularly skin cancer [27,28].…”

Section: Discussionmentioning

confidence: 99%

Twenty Years of Arsenic Contamination and Arsenicosis Patients in a Village of Bangladesh

Shojaei¹,

Faruquee²,

Khan³

2020

AJPHR

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Background: Arsenic contamination in groundwater of Bangladesh was first detected in 1993 and still a major public health problem in the country. In 1997, Samta was identified as a severely arsenic contaminated village and many villagers were found to suffering from arsenicosis. Methods: A series of surveys were carried out in Samta village in the years 1997, 2002, 2008 and 2017 to assess the situation of arsenic contamination and the status of arsenicosis in the village. The water sources and the entire population of the village were included in the study. Results: In 1997 about 87% of the shallow tubewells in Samta village were arsenic-contaminated and 10.1% villagers had arsenicosis. Twenty years later in 2017, about 90% shallow tubewells were arsenic contaminated, 39 deep tubewells and a pond sand filter were installed in the village and 2.3% of the villagers had arsenicosis. On an average 43.8% arsenicosis patients had recovered from the illness and condition of 21.2% patients had deteriorated or remained unchanged. During the 20-year period 37(6.1%) arsenicosis patients and 185(1.6%) non-arsenicosis villagers had died. The main cause of death among arsenicosis patients was cancer (40.5%) and among non-arsenicosis villagers the cause was geriatric problem (11.8%). The mean age at death was 57.6 years and 61.2 years respectively. Conclusion: In twenty years, measures were undertaken to make available arsenic-safe water options and people were motivated to stop the use of arsenic-contaminated water and to increase the intake of protein and vitamin AEC rich food. Recovery had occurred in a substantial proportion of patients.

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Oxidative stress-related liver dysfunction by sodium arsenite: Alleviation byPistacia lentiscusoil

Cited by 31 publications

References 75 publications

Pumpkin seed oil alleviates oxidative stress and liver damage induced by sodium nitrate in adult rats: biochemical and histological approach

Pumpkin seed oil alleviates oxidative stress and liver damage induced by sodium nitrate in adult rats: biochemical and histological approach

The role of molecular modelling strategies in validating the effects of chrysin on sodium arsenite-induced chromosomal and DNA damage

Twenty Years of Arsenic Contamination and Arsenicosis Patients in a Village of Bangladesh

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