Oxidative stress response to air particle pollution in a rat nutritional growth retardation model

Kurtz, M.; Astort, Francisco; Lezón, Christian E.; Ferraro, Sebastián Ariel; Maglione, Guillermo Alberto; Orona, Nadia Soledad; Friedman, Sílvia; Boyer, P; Tasat, Deborah Ruth

doi:10.1080/15287394.2018.1519747

Cited by 14 publications

(5 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Evaluation of ROFA effects on the liver showed an increase in the number of lymphocytes in the liver parenchyma and of binucleated hepatocytes; the latter parameter is associated with hepatic regeneration as a response to toxic tissue damage triggered by xenobiotic or dietary-induced liver damage. Our results highlight the key role of nutritional status in the ability to respond to air pollutants [11,81,[105][106][107][108].…”

Section: Malnutrition and Air Pollution In Children A Vulnerable Popu...mentioning

confidence: 76%

“…Lave and Seskin were among the first to demonstrate a significant association between air pollution and child death due to environment-related respiratory diseases in their study across 117 U.S. metropolitan areas [10]. Although more recent studies conducted by our research group using a model that reproduces a condition of chronic human undernutrition showed that undernourished children are potentially a high-risk group [11], there is little information on the impact of the local and systemic effect of airborne particulate matter on undernourished children (Table 1).…”

Section: Introductionmentioning

confidence: 91%

See 1 more Smart Citation

Perspective Chapter: Malnutrition and Air Pollution in Latin America – Impact of Two Stressors on Children’s Health

Kurtz¹,

Lezón²,

Boyer³

et al. 2023

Combating Malnutrition Through Sustainable Approaches

Self Cite

View full text Add to dashboard Cite

Nowadays, the evolution of the concept of nutrition has acquired a notion of three concurrent dimensions. Nutrition was considered an exclusively biological process while now, it comprises social and ecological aspects. Inadequate nutrition and air pollution are two major nongenetic environmental factors known to cause serious public health problems worldwide. Air pollution does not impact in the same way on the population at large, being particularly the children one of the most vulnerable subpopulations. Additionally, the nutritional status may modify the susceptibility to air pollution exposure and cause a wide range of acute and chronic cardio-respiratory diseases. Moreover, undernutrition is identified as a major health problem with devastating healthcare effects on the individual, social, and economic development. On a global scale, chronic undernourishment affects 144 million children younger than 5 years. However, the mechanism linking undernutrition and air pollution exposure still remains unclear. At present, only few epidemiological studies have been reported associating child malnutrition and air pollution. Therefore, a better understanding of the interactions between undernutrition and air pollution exposure is needed to guide action by individuals and governments.

show abstract

Section: Malnutrition and Air Pollution In Children A Vulnerable Popu...mentioning

confidence: 76%

Section: Introductionmentioning

confidence: 91%

Perspective Chapter: Malnutrition and Air Pollution in Latin America – Impact of Two Stressors on Children’s Health

Kurtz¹,

Lezón²,

Boyer³

et al. 2023

Combating Malnutrition Through Sustainable Approaches

Self Cite

View full text Add to dashboard Cite

show abstract

“…Folate deficiency and air pollution may jointly result in higher risk of cardiovascular disease via the way of CT/TT methylenetetrahydrofolate reductase gene mutation (Varga et al 2005). Besides, rat nutritional growth retardation models also showed some evidences, and nutritional status played a key role in response to ambient air pollution (Kurtz et al 2018). In sum, underweight may modify PM-induced BP effect via enhanced arterial vasoconstrictor response through a variety of biological pathways.…”

Section: Discussionmentioning

confidence: 97%

Does underweight amplify the relationship between short-term particulate matter exposure and blood pressure in children and adolescents: a large cross-sectional study in a metropolis of China

Shen

et al. 2020

Environ Sci Pollut Res

View full text Add to dashboard Cite

Overweight/obesity modified the effects of ambient particulate matter (PM) exposure on blood pressure (BP). This study aims to assess whether interaction of underweight and short-term PM exposure on BP exists in Chinese children. A cross-sectional analysis including 144,513 children aged 6 to 17 years in 2016 Health Promotion Program for Children and Adolescents of Suzhou, China, was performed. Daily concentrations of inhalable PM (PM 10 ) and fine PM (PM 2.5 ) were extracted from air monitoring stations close to students' schools. We applied generalized linear mixed-effects models to estimate the interactions. Estimated changes (95% confidence intervals (CIs)) of systolic BP (SBP), diastolic BP (DBP), and odds ratios (ORs) (95% CIs) for prevalence of HBP were calculated. Significant interactions between PM and underweight on BP and prevalence of high BP (HBP) were observed. For example, at lag 6, the ORs (95% CIs) for HBP by each 10 μg/m 3 changes of PM 2.5 were 1.066 (1.039, 1.093) and 1.036 (1.028, 1.043) among underweight and normal weight subjects, respectively; these values for PM 10 were 1.048 (1.031, 1.065) and 1.025 (1.021, 1.030). At lag 5, the increases of SBP for PM 2.5 were 0.32 (95% CI 0.22, 0.43) mmHg and 0.23 (95% CI 0.29, 0.26) mmHg, while changes of DBP were 0.27 (95% CI 0.18, 0.35) mmHg and 0.19 (95% CI 0.16, 0.21) mmHg among underweight and normal weight subjects, respectively. Stratified analyses demonstrated that these interactions were only obtained in males. Effects of short-term PM exposure on BP and prevalence of HBP are enhanced in underweight children and adolescents.

show abstract

“…The inhalation of air PM in the lungs causes local oxidative stress, which is enhanced by the presence of highly reactive oxidant gases such as O 3 and NO 2 [12,13]. The overproduction of reactive oxygen species (ROS), especially superoxide, can be related to the PM-mediated activation of nicotinamide adenine dinucleotide phosphate oxidases (NADPH oxidase), mitochondrial enzymes, and uncoupled nitric oxide (NO) synthase, with a concomitant progressive depletion of antioxidant defenses as superoxide dismutase (SOD) [14][15][16]. Generated ROS lead to the oxidation of proteins and lipids in the surfactant milieu, in endothelial cells and in alveolar macrophages, which results in the induction of inflammation through activation of Toll-like receptor (TLR) signaling [17].…”

Section: Mechanisms Of Actionmentioning

confidence: 99%

Air Pollution: Another Threat to HDL Function

Ossoli

Cetti

Gomaraschi

2022

IJMS

View full text Add to dashboard Cite

Epidemiological studies have consistently demonstrated a positive association between exposure to air pollutants and the incidence of cardiovascular disease, with the strongest evidence for particles with a diameter < 2.5 μm (PM2.5). Therefore, air pollution has been included among the modifiable risk factor for cardiovascular outcomes as cardiovascular mortality, acute coronary syndrome, stroke, heart failure, and arrhythmias. Interestingly, the adverse effects of air pollution are more pronounced at higher levels of exposure but were also shown in countries with low levels of air pollution, indicating no apparent safe threshold. It is generally believed that exposure to air pollution in the long-term can accelerate atherosclerosis progression by promoting dyslipidemia, hypertension, and other metabolic disorders due to systemic inflammation and oxidative stress. Regarding high density lipoproteins (HDL), the impact of air pollution on plasma HDL-cholesterol levels is still debated, but there is accumulating evidence that HDL function can be impaired. In particular, the exposure to air pollution has been variably associated with a reduction in their cholesterol efflux capacity, antioxidant and anti-inflammatory potential, and ability to promote the release of nitric oxide. Further studies are needed to fully address the impact of various air pollutants on HDL functions and to elucidate the mechanisms responsible for HDL dysfunction.

show abstract

Oxidative stress response to air particle pollution in a rat nutritional growth retardation model

Cited by 14 publications

References 59 publications

Perspective Chapter: Malnutrition and Air Pollution in Latin America – Impact of Two Stressors on Children’s Health

Perspective Chapter: Malnutrition and Air Pollution in Latin America – Impact of Two Stressors on Children’s Health

Does underweight amplify the relationship between short-term particulate matter exposure and blood pressure in children and adolescents: a large cross-sectional study in a metropolis of China

Air Pollution: Another Threat to HDL Function

Contact Info

Product

Resources

About