Oxidative Stress Responses and Redox Signalling Mechanisms in Bacillus subtilis and Staphylococcus aureus

Antelmann, Haike

doi:10.1016/b978-0-12-397169-2.00013-5

Cited by 6 publications

(3 citation statements)

References 203 publications

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“…OxyR contains a regulatory domain, which senses H 2 O 2 , and a DNA binding domain, which modulates target gene expression directly. Similarly, PerR, an alternative transcription factor to OxyR, was found in Gram-positive bacteria ( Bacillus subtilis) [ 103 ]. The regulon of PerR contains most of the same stress response genes as the OxyR regulon [ 104 ].…”

Section: Responses To Oxidative Stressmentioning

confidence: 99%

To Be or Not to Be? Are Reactive Oxygen Species, Antioxidants, and Stress Signalling Universal Determinants of Life or Death?

Szechyńska‐Hebda

Ghalami

Kamran

et al. 2022

Cells

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In the environmental and organism context, oxidative stress is complex and unavoidable. Organisms simultaneously cope with a various combination of stress factors in natural conditions. For example, excess light stress is accompanied by UV stress, heat shock stress, and/or water stress. Reactive oxygen species (ROS) and antioxidant molecules, coordinated by electrical signalling (ES), are an integral part of the stress signalling network in cells and organisms. They together regulate gene expression to redirect energy to growth, acclimation, or defence, and thereby, determine cellular stress memory and stress crosstalk. In plants, both abiotic and biotic stress increase energy quenching, photorespiration, stomatal closure, and leaf temperature, while toning down photosynthesis and transpiration. Locally applied stress induces ES, ROS, retrograde signalling, cell death, and cellular light memory, then acclimation and defence responses in the local organs, whole plant, or even plant community (systemic acquired acclimation, systemic acquired resistance, network acquired acclimation). A simplified analogy can be found in animals where diseases vs. fitness and prolonged lifespan vs. faster aging, are dependent on mitochondrial ROS production and ES, and body temperature is regulated by sweating, temperature-dependent respiration, and gene regulation. In this review, we discuss the universal features of stress factors, ES, the cellular production of ROS molecules, ROS scavengers, hormones, and other regulators that coordinate life and death.

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Section: Responses To Oxidative Stressmentioning

confidence: 99%

To Be or Not to Be? Are Reactive Oxygen Species, Antioxidants, and Stress Signalling Universal Determinants of Life or Death?

Szechyńska‐Hebda

Ghalami

Kamran

et al. 2022

Cells

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“…As the primary enzyme involved in cellular response to oxidative damage, SOD may be more sensitive to toxic substances than CAT and GSH. 60,61 Thus, due to the compensation mechanism of organisms, the initial perturbations of TBPH on CAT and GSH can be compensated at 0.1 μg/L, while those on SOD are not sufficient to be offset. 62 These results confirmed that embryonic exposure to TBPH led to hepatic lipid metabolism disorders and oxidative stress, the most prominent features of NAFLD.…”

Section: Confirming the Effects On Lipid Metabolism Andmentioning

confidence: 99%

Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate Enhances foxo1-Mediated Lipophagy to Remodel Lipid Metabolism in Zebrafish Liver

Zhou,

Li,

et al. 2024

Environ. Sci. Technol.

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An emerging environmental contaminant, bis(2-ethylhexyl)-2,3,4,5tetrabromophthalate (TBPH), can bioaccumulate in the liver and affect hepatic lipid metabolism. However, the in-depth mechanism has yet to be comprehensively explored. In this study, we utilized transgenic zebrafish Tg (Apo14: GFP) to image the interference of TBPH on zebrafish liver development and lipid metabolism at the early development stage. Using integrated lipidomic and transcriptomic analyses to profile the lipid remodeling effect, we uncovered the potential effects of TBPH on lipophagy-related signaling pathways in zebrafish larvae. Decreased lipid contents accompanied by enhanced lipophagy were confirmed by the measurements of Oil Red O staining and transmission electron microscopy in liver tissues. Particularly, the regulatory role of the foxo1 factor was validated via its transcriptional inhibitor. Double immunofluorescence staining integrated with biochemical analysis indicated that the enhanced lipophagy and mitochondrial fatty acid oxidation induced by TBPH were reversed by the foxo1 inhibitor. To summarize, our study reveals, for the first time, the essential role of foxo1-mediated lipophagy in TBPH-induced lipid metabolic disorders and hepatoxicity, providing new insights for metabolic disease studies and ecological health risk assessment of TBPH.

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“…The amino acids cysteine, methionine, and tryptophan are especially vulnerable to the oxidative action of hydrogen peroxide, which can lead to both reversible changes, expressed in formation of sulfonic acid and thiol, and irreversible changes leading to formation of sulfuric and sulfonic acids (3). Thus, in response to the action of various reactive oxygen species (ROS), bacterial cells undergo a radical modification of the proteome, which is not necessarily harmful to bacteria.…”

Section: Introductionmentioning

confidence: 99%

Changes of the oxidative stress indices in pathogenic bacterial cultures under the action of novel chemical compounds

Lozan-Tirsu

ZARICIUC

2022

OH&RM

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Introduction. It is known that excessive formation of hydrogen peroxide in the microbial cultures under the action of chemical compounds with antibacterial effects is the first stage in the formation of oxidative stress. Thus, it became appropriate to conduct a study that would make it possible to control the level of oxidative stress induced by chemical compounds in cultures of pathogenic microorganisms. Material and methods. The objects of the in vitro study were Cu(II) coordination compounds; Co(II), Zn(II) and aromatic propenones synthesized a t the Department of Inorganic Chemistry of the State University of Moldova. Antimicrobial activity was tested on 5 reference strains. The level of oxidative stress was controlled using the hydrogen peroxide test, and the level of lipid peroxidation was determined indirectly by monitoring the product of peroxidation, namely the malondialdehyde. Results. Under the action of new chemical compounds with antimicrobial properties on reference cultures of Staphylococcus aureus ATCC 25923, Bacillus cereus ГИСК 8035, Escherichia coli ATCC 25922, Shigella sonnei ATCC 25931 and Salmonella enterica (Salmonella abony ГИСК 03/03y) in cultures that create a state of oxidative stress, confirmed by the accumulation of hydrogen peroxide and lipid peroxidation products. Conclusions. Thus, the process of lipid peroxidation, which follows the pattern of chain reactions, is one of the reactions that lead to the death of cell culture. The level of hydrogen peroxide formed under the action of the tested compounds was also monitored.

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Oxidative Stress Responses and Redox Signalling Mechanisms in Bacillus subtilis and Staphylococcus aureus

Cited by 6 publications

References 203 publications

To Be or Not to Be? Are Reactive Oxygen Species, Antioxidants, and Stress Signalling Universal Determinants of Life or Death?

To Be or Not to Be? Are Reactive Oxygen Species, Antioxidants, and Stress Signalling Universal Determinants of Life or Death?

Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate Enhances foxo1-Mediated Lipophagy to Remodel Lipid Metabolism in Zebrafish Liver

Changes of the oxidative stress indices in pathogenic bacterial cultures under the action of novel chemical compounds

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