Oxidative stress responses in two marine diatoms during acute n-butyl acrylate exposure and the toxicological evaluation with the IBRv2 index

Du, Shuhao; Meng, Fanping; Duan, Weiyan; Liu, Qunqun; Li, Hao; Peng, Xiaoling

doi:10.1016/j.ecoenv.2022.113686

Cited by 7 publications

(1 citation statement)

References 39 publications

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“…Much emphasis has been paid to the construction of scaffolds with tiny molecular structures as their principal structural design in the hunt for potential anticancer candidates. , The acrylate moiety, a synthetic small molecular scaffold, is a prized element in modern medical chemistry . The molecules based on this scaffold have a wide range of actions, such as anticancer, antioxidant, and anti-inflammatory medicines, due to their broad scope and affinity for a number of biological targets. − …”

Section: Introductionmentioning

confidence: 99%

Novel Acrylate-Based Derivatives: Design, Synthesis, Antiproliferative Screening, and Docking Study as Potential Combretastatin Analogues

Fayad,

Altalhi,

Abualnaja

et al. 2023

ACS Omega

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A variety of 3-(4-chlorophenyl) acrylic acids 4a,b and 3-(4chlorophenyl)acrylate esters 5a−i were synthesized and structurally proven by spectroscopic studies such as IR, 1 H NMR, and 13 C NMR as well as mass spectrometry. All substances were investigated for their antiproliferative efficacy against the MDA-MB-231 cell line. Among these, acrylic acid compound 4b demonstrated the most potent cytotoxic effect with an IC 50 value of 3.24 ± 0.13 μM, as compared to CA-4 (IC 50 = 1.27 ± 09 μM). Additionally, acrylic acid molecule 4b displayed an inhibitory effect against βtubulin polymerization with a percentage inhibition of 80.07%. Furthermore, compound 4b was found to produce considerable cell cycle arrest at the G2/ M stage and cellular death, as demonstrated by FACS analysis. In addition, the in vivo antitumor screening of the sodium salt of acrylic acid 4b was carried out, and the results have shown that the tested molecule showed a significant decrease in viable EAC count and EAC volume, accompanied by a considerable increase in the life span prolongation, if compared to the positive control group. Furthermore, molecular modeling studies were performed to understand how the highly efficient chemicals 4b and 5e interact with the colchicine-binding region on tubulin. This work aims to shed light on the reasons behind their exceptional cytotoxicity and their better capacity to inhibit tubulin in comparison to CA-4.

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