Oxidative stress status, caspase-3, stromal enzymes and mitochondrial respiration and swelling of Paramecium caudatum in responding to the toxicity of Fe3O4 nanoparticles

Henine, Sara; Rouabhi, Rachid; Gasmi, Salim; Aml, Amrouche; Amna, Abide; Aya, Salmi; Nadjiba, Toualbia; Taib, Chahinez; Bouteraa, Zina; Hajer, Chenikher; Boussekine, Samira; Kebieche, Mohamed; Mariem, Aouimeur; Djabri, Belgacem

doi:10.1007/s13530-016-0273-1

Cited by 9 publications

(2 citation statements)

References 35 publications

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“…The current study found a significant dose-dependent elevated levels of caspase-3 protein in ovarian and uterine tissues of TMX-treated rats. This outcomes are consistent with the findings of the previous work (Sara et al 2016 ; Gasmi et al 2019 ). Through the stimulation of apoptosis and endoplasmic reticulum stress, TMX administration in mice affected ovarian homeostasis and lowered oocyte quality (Liu et al 2021 ).…”

Section: Discussionsupporting

confidence: 94%

Induction of apoptosis, oxidative stress, hormonal, and histological alterations in the reproductive system of thiamethoxam-exposed female rats

El-Din

Ghareeb

El-Garawani

et al. 2023

Environ Sci Pollut Res

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The present study aimed to investigate the oral toxic effects of 1/10 LD50 and 1/5 LD50 of thiamethoxam (TMX), a neonicotinoid insecticide, on the reproductive system of female Wistar rats. Thirty female rats were divided into three groups and supplied orally with either; saline solution, 1/10 LD50 of TMX (156 mg/kg) or 1/5 LD50 of TMX (312 mg/kg). The daily administration was extended for 30 days. Investigating the parameters of oxidative stress, hormonal levels, histopathological alterations, and the apoptotic markers (P53, BAX, BCL-2, and caspase-3) was performed in the uterus and ovary of rats. Results showed significant changes in the body weight gain, and relative weight of the left and right ovaries and uterus. Moreover, luteinizing hormone (LH), estradiol (ED), and progesterone (PG) serum levels were not significantly altered following TMX oral administration. The level of follicle-stimulating hormone in the TMX-exposed group (156 mg/kg) was significantly increased; however, a significant decrease was observed in TMX-exposed animals (312 mg/kg). TMX induced significant oxidative stress in exposed groups by reducing the activities of superoxide dismutase (SOD), glutathione (GSH), and catalase (CAT), and elevating malondialdehyde (MDA) levels. Following hematoxylin and eosin staining, the microscopic examination revealed deteriorated luteal cells with vacuolation in the corpus luteum, a follicle containing a degenerated oocyte and degeneration/necrosis of the circular muscle layer with a high rate of apoptotic cells in TMX-exposed animals. TMX induced transcriptional alterations in apoptosis-related genes shifting towards the activation of the intrinsic apoptotic pathway. Collectively, results suggest the toxic effect of the TMX on the reproductive health of female Wistar rats.

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Section: Discussionsupporting

confidence: 94%

Induction of apoptosis, oxidative stress, hormonal, and histological alterations in the reproductive system of thiamethoxam-exposed female rats

El-Din

Ghareeb

El-Garawani

et al. 2023

Environ Sci Pollut Res

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“…The same mechanism occurs in the fungus bud, which is a fungus that is growing. Generated ROS causes oxidative stress in mitochondria, where the fungal cell respiration occurs [61]. Then, DNA and fungal cell nuclei are attacked by ROS.…”

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confidence: 99%

Effects of ZnO nanoparticles on the antifungal performance of Fe₃O₄/ZnO nanocomposites prepared from natural sand

Taufiq

Ulya

Yogihati

et al. 2020

Adv. Nat. Sci: Nanosci. Nanotechnol.

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In the present study, the eco-friendly and economical methods have been developed by employing natural iron sand as a main precursor to create Fe3O4/ZnO nanocomposites (NCs). The formation of Fe3O4/ZnO NCs was confirmed using XRD, synchrotron-based SAXS, FTIR spectroscopy, and SEM. The XRD results revealed that the Fe3O4 and ZnO crystallised spinel cubic and hexagonal wurtzite structures. The SAXS results exposed the construction of fractal dimension with the values of 3.20–3.70, which indicated a compact structure in 3-dimensions. The SEM images showed that the morphology of the samples tended to agglomerate in nanometric size. The FTIR spectra proved the presence of the Fe–O and Zn–O bonds as the main components of the NCs. The UV–vis spectroscopy analysis revealed that the bandgap energy of the Fe3O4/ZnO NCs ranged from 2.244 to 3.533 eV. Furthermore, the Fe3O4/ZnO NCs demonstrated superparamagnetic behaviour with the blocking temperature below 212 K, and their saturation magnetisation increased with increasing Fe3O4 content. Interestingly, all samples demonstrated excellent inhibitory performance against C. albicans, which indicates that the Fe3O4/ZnO NCs synthesised by eco-friendly and economical methods from natural iron sand for the first time are novel candidates for use as high-performance antifungal agents.

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Toxicity of Fe3O4 nanoparticles on oxidative stress status, stromal enzymes and mitochondrial respiration and swelling of Oryctolagus cuniculus brain cortex

Taib

Rouabhi

Gasmi

et al. 2016

Toxicol. Environ. Health Sci.

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Oxidative stress status, caspase-3, stromal enzymes and mitochondrial respiration and swelling of Paramecium caudatum in responding to the toxicity of Fe3O4 nanoparticles

Cited by 9 publications

References 35 publications

Induction of apoptosis, oxidative stress, hormonal, and histological alterations in the reproductive system of thiamethoxam-exposed female rats

Induction of apoptosis, oxidative stress, hormonal, and histological alterations in the reproductive system of thiamethoxam-exposed female rats

Effects of ZnO nanoparticles on the antifungal performance of Fe₃O₄/ZnO nanocomposites prepared from natural sand

Toxicity of Fe3O4 nanoparticles on oxidative stress status, stromal enzymes and mitochondrial respiration and swelling of Oryctolagus cuniculus brain cortex

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Oxidative stress status, caspase-3, stromal enzymes and mitochondrial respiration and swelling of Paramecium caudatum in responding to the toxicity of Fe3O4 nanoparticles

Cited by 9 publications

References 35 publications

Induction of apoptosis, oxidative stress, hormonal, and histological alterations in the reproductive system of thiamethoxam-exposed female rats

Induction of apoptosis, oxidative stress, hormonal, and histological alterations in the reproductive system of thiamethoxam-exposed female rats

Effects of ZnO nanoparticles on the antifungal performance of Fe3O4/ZnO nanocomposites prepared from natural sand

Toxicity of Fe3O4 nanoparticles on oxidative stress status, stromal enzymes and mitochondrial respiration and swelling of Oryctolagus cuniculus brain cortex

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Product

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Effects of ZnO nanoparticles on the antifungal performance of Fe₃O₄/ZnO nanocomposites prepared from natural sand