Oxidative stress, telomere length, and frailty in an old age population

Martínez‐Ezquerro, José Darío; Rodríguez-Castañeda, Aleida; Ortiz-Ramírez, Mauricio; Sánchez-Garcí­a, Sergio; Rosas-Vargas, Haydeé; Sánchez-Arenas, Rosalinda; García-delaTorre, Paola

doi:10.1101/414680

Cited by 4 publications

(4 citation statements)

References 26 publications

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“…The presence of functional telomerase is a necessary condition for maintaining the telomere length, hence, preserving healthy cell and long-term immune functions 47. Even though no study has been done on the direct interaction between telomerase activity and cognitive frailty, telomere shortening is associated with both physical frailty and cognitive decline 48–50. In line with this, the contribution of telomere shortening to persistent DNA damage response during replicative senescence, and the irreversible loss of the division potential of somatic cells have been reported 51.…”

Section: Discussionmentioning

confidence: 99%

<p>Cognitive frailty among Malaysian older adults: baseline findings from the LRGS TUA cohort study</p>

Rivan¹,

Shahar²,

Rajab³

et al. 2019

CIA

112

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Purpose This study was aimed at determining the presence of cognitive frailty and its associated factors among community-dwelling older adults from the “LRGS-Towards Useful Aging (TUA)” longitudinal study. Patients and methods The available data related to cognitive frailty among a sub-sample of older adults aged 60 years and above (n=815) from two states in Malaysia were analysed. In the LRGS-TUA study, a comprehensive interview-based questionnaire was administered to obtain the socio-demographic information of the participants, followed by assessments to examine the cognitive function, functional status, dietary intake, lifestyle, psychosocial status and biomarkers associated with cognitive frailty. The factors associated with cognitive frailty were assessed using a bivariate logistic regression (BLR). Results The majority of the older adults were categorized as robust (68.4%), followed by cognitively pre-frail (37.4%) and cognitively frail (2.2%). The data on the cognitively frail and pre-frail groups were combined for comparison with the robust group. A hierarchical BLR indicated that advancing age (OR=1.04, 95% CI:1.01–1.08, p <0.05) and depression (OR=1.49, 95% CI:1.34–1.65, p <0.001) scored lower on the Activity of Daily Living (ADL) scale (OR=0.98, 95% CI:0.96–0.99, p <0.05), while low social support (OR=0.98, 95% CI:0.97–0.99, p <0.05) and low niacin intake (OR=0.94, 95% CI:0.89–0.99, p <0.05) were found to be significant factors for cognitive frailty. Higher oxidative stress (MDA) and lower telomerase activity were also associated with cognitive frailty ( p <0.05). Conclusion Older age, a lower niacin intake, lack of social support, depression and lower functional status were identified as significant factors associated with cognitive frailty among older Malaysian adults. MDA and telomerase activity can be used as potential biomarkers for the identification of cognitive frailty.

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Section: Discussionmentioning

confidence: 99%

<p>Cognitive frailty among Malaysian older adults: baseline findings from the LRGS TUA cohort study</p>

Rivan¹,

Shahar²,

Rajab³

et al. 2019

CIA

112

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“…Although more research is required to fully understand ROS-induced damage to telomeric DNA, studies suggests that this may be an important factor to take into consideration [ 247 ]. Furthermore, even if oxidative stress and telomere shortening in humans still have not been directly correlated, there is a great association with frailty typical of the elderly [ 248 ]. Oxidative stress and inflammation play an important role in valvular calcification.…”

Section: Aging Oxidative Stress and Cardiovascular Diseasesmentioning

confidence: 99%

The Role of Oxidative Stress in Cardiovascular Aging and Cardiovascular Diseases

Izzo

Vitillo

Pietro

et al. 2021

Life

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Aging can be seen as process characterized by accumulation of oxidative stress induced damage. Oxidative stress derives from different endogenous and exogenous processes, all of which ultimately lead to progressive loss in tissue and organ structure and functions. The oxidative stress theory of aging expresses itself in age-related diseases. Aging is in fact a primary risk factor for many diseases and in particular for cardiovascular diseases and its derived morbidity and mortality. Here we highlight the role of oxidative stress in age-related cardiovascular aging and diseases. We take into consideration the molecular mechanisms, the structural and functional alterations, and the diseases accompanied to the cardiovascular aging process.

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“…Several possible mechanisms for this association including (1) Magnesium plays a role in telomere maintenance and the activity of telomerase; thus, increasing magnesium supplement could extend LTL [31]. (2) Long-term intake of magnesium have demonstrated anti-in ammatory and antioxidative properties which may impact on LTL [34,35]. However, more studies are needed to con rm our results and further examine the underlying mechanisms.…”

Section: Discussionmentioning

confidence: 82%

Dietary Magnesium Intake and its Association with Leukocyte Telomere Length in US Middle-aged and Elderly Adults

Bai

et al. 2021

Preprint

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Background: Magnesium supplementation may extend the life span; however, the biological mechanism is still unknown. Leukocyte telomere length (LTL) is a marker of cell aging and biological health in humans. Data concerning whether magnesium supplementation can maintain telomere length, thus prolonging life are limited.Purpose: To investigate the association between dietary magnesium intake and LTL in US middle-aged and elderly adults. Methods: A total of 4039 US adults aged ≥45 years from National Health and Nutrition Examination Survey (NHANES, 1999-2002). Dietary magnesium intake was collected by a trained interviewer using 24-hour dietary recall method and LTL was obtained using the quantitative polymerase chain reaction (PCR) method. Multivariate linear regression analysis was performed to evaluate the the crude and adjusted association of dietary magnesium intake with LTL. Results: The overall mean (SD) of LTL was 5.6 (0.6) kp. After adjusting potential confounders, every 1 mg increase in log-transformed dietary magnesium intake was associated with 0.20 kp [95% confidence intervals (CI): 0.05-0.34] longer LTL. Participants with the highest tertile (≥ 299 mg) of dietary magnesium intake had statistically significant longer LTL (β = 0.07, P=0.038) compared with the lowest tertile (< 198 mg), with significant linear trends across tertiles. Moreover, the association between dietary magnesium intake and LTL was significantly stronger in participants with higher levels of education (≥ high school compared with < high school, P for interaction = 0.002). E-value analysis suggested robustness to unmeasured confounding.Conclusions: Our findings suggested that increased dietary magnesium intake was associated with longer LTL. Theses warrant additional investigation.

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Oxidative stress, telomere length, and frailty in an old age population

Cited by 4 publications

References 26 publications

<p>Cognitive frailty among Malaysian older adults: baseline findings from the LRGS TUA cohort study</p>

<p>Cognitive frailty among Malaysian older adults: baseline findings from the LRGS TUA cohort study</p>

The Role of Oxidative Stress in Cardiovascular Aging and Cardiovascular Diseases

Dietary Magnesium Intake and its Association with Leukocyte Telomere Length in US Middle-aged and Elderly Adults

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