Oxidative stress, telomeres and cellular senescence: What non-drug interventions might break the link?

Erusalimsky, Jorge D.

doi:10.1016/j.freeradbiomed.2020.02.008

Cited by 31 publications

(14 citation statements)

References 108 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, telomere oxidative lesions are less efficiently repaired because of the telomere heterochromatin state, suggesting that telomeres are most vulnerable to oxidative damage (Smith, 2018;Coluzzi et al, 2019;Singh et al, 2019). Accordingly, oxidative stress is considered to be the main cause of telomere shortening (Erusalimsky, 2020). Cigarette smoke, a source of exogenous pro-oxidants, has been confirmed to be associated with increased oxidative stress in the ovary (Sobinoff et al, 2013;Mai et al, 2014;Kim et al, 2018;.…”

Section: Oxidative Stress and Telomeres In The Ovariesmentioning

confidence: 99%

The Role of Oxidative Stress and Natural Antioxidants in Ovarian Aging

et al. 2021

View full text Add to dashboard Cite

The ovarian system comprises vital organs in females and is of great significance for the maintenance of reproductive potential and endocrine stability. Although complex pathogenesis undoubtedly contributes to ovarian aging, increasing attention is being paid to the extensive influence of oxidative stress. However, the role of oxidative stress in ovarian aging is yet to be fully elucidated. Exploring oxidative stress-related processes might be a promising strategy against ovarian aging. In this review, compelling evidence is shown that oxidative stress plays a role in the etiology of ovarian aging and promotes the development of other ovarian aging-related etiologies, including telomere shortening, mitochondrial dysfunction, apoptosis, and inflammation. In addition, some natural antioxidants such as quercetin, resveratrol, and curcumin have a protective role in the ovaries through multiple mechanisms. These findings raise the prospect of oxidative stress modulator-natural antioxidants as therapeutic interventions for delaying ovarian aging.

show abstract

Section: Oxidative Stress and Telomeres In The Ovariesmentioning

confidence: 99%

The Role of Oxidative Stress and Natural Antioxidants in Ovarian Aging

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Further investigations focused on the missing links between oxidative stress and telomere length. Initially, research was based on in vitro studies using cultured cells that demonstrated the association between oxidative stress inductors and premature senescence [8]. Epel et al discovered the existence of the association between oxidative stress and accelerated telomeres shortening in humans in 2004 [9].…”

Section: Psychological Stress and Agingmentioning

confidence: 99%

The Link between Chronic Stress and Accelerated Aging

et al. 2020

View full text Add to dashboard Cite

People exposed to chronic stress age rapidly. The telomeres in their cells of all types shorten faster. Inflammation is another important feature of stress that, along with aging, accounts for the phenomenon of inflammaging. In addition to aging itself, inflammaging can contribute to the development of several pathologies, including atherosclerosis, diabetes, hypertension, and others. Oxidative stress is one of the main mechanisms related to stress. Oxidative stress is caused by the over-production of reactive oxygen species (ROS) that can damage various tissues. The main source of ROS is mitochondria. Being suppressed by mitochondrial mutations, mitophagy can aggravate the situation. In this case, the aging-specific pro-inflammatory changes are amplified. It happens because of the inability of cells to maintain the normal state of mitochondria. Macrophages are the crucial element of the innate immunity associated with the chronic inflammation and, subsequently, with the inflammaging. In this review, we focus on the therapy approaches potentially reducing the deleterious effects of oxidative stress. These include stimulation of mitophagy, activation of mitochondrial uncoupling, induction of the expression of the telomerase catalytic component gene, and use of antioxidants. Any method reducing oxidative stress should improve post-traumatic stress disorder.

show abstract

“…The ability to slow telomere shortening and activate telomerase has been shown for many natural compounds ( Table 2 ). Most of them protect telomeric DNA by reducing damage by genotoxic agents, but their effect is small [ 81 , 675 ]. A promising strategy could also be coordinating the organization and stability of telomeres, for example, by targeting guanine-quadruplexes.…”

Section: Pharmacological Interventions Protecting Genomementioning

confidence: 99%

Genome-Protecting Compounds as Potential Geroprotectors

Proshkina

Shaposhnikov

Moskalev

2020

IJMS

View full text Add to dashboard Cite

Throughout life, organisms are exposed to various exogenous and endogenous factors that cause DNA damages and somatic mutations provoking genomic instability. At a young age, compensatory mechanisms of genome protection are activated to prevent phenotypic and functional changes. However, the increasing stress and age-related deterioration in the functioning of these mechanisms result in damage accumulation, overcoming the functional threshold. This leads to aging and the development of age-related diseases. There are several ways to counteract these changes: (1) prevention of DNA damage through stimulation of antioxidant and detoxification systems, as well as transition metal chelation; (2) regulation of DNA methylation, chromatin structure, non-coding RNA activity and prevention of nuclear architecture alterations; (3) improving DNA damage response and repair; (4) selective removal of damaged non-functional and senescent cells. In the article, we have reviewed data about the effects of various trace elements, vitamins, polyphenols, terpenes, and other phytochemicals, as well as a number of synthetic pharmacological substances in these ways. Most of the compounds demonstrate the geroprotective potential and increase the lifespan in model organisms. However, their genome-protecting effects are non-selective and often are conditioned by hormesis. Consequently, the development of selective drugs targeting genome protection is an advanced direction.

show abstract

Oxidative stress, telomeres and cellular senescence: What non-drug interventions might break the link?

Cited by 31 publications

References 108 publications

The Role of Oxidative Stress and Natural Antioxidants in Ovarian Aging

The Role of Oxidative Stress and Natural Antioxidants in Ovarian Aging

The Link between Chronic Stress and Accelerated Aging

Genome-Protecting Compounds as Potential Geroprotectors

Contact Info

Product

Resources

About