2017
DOI: 10.1155/2017/1512745
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Oxidative Stress Triggered by Apigenin Induces Apoptosis in a Comprehensive Panel of Human Cervical Cancer‐Derived Cell Lines

Abstract: Recently, the cytotoxic effects of apigenin (4′,5,7-trihydroxyflavone), particularly its marked inhibition of cancer cell viability both in vitro and in vivo, have attracted the attention of the anticancer drug discovery field. Despite this, there are few studies of apigenin in cervical cancer, and these studies have mostly been conducted using HeLa cells. To evaluate the possibility of apigenin as a new therapeutic candidate for cervical cancer, we evaluated its cytotoxic effects in a comprehensive panel of h… Show more

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Cited by 81 publications
(57 citation statements)
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References 82 publications
(93 reference statements)
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“…p53 is strongly involved in the control of ROS level, since it can have both pro-oxidant and anti-oxidant properties that can be mediated by the inhibition or the activation of catalase activity [ 38 ]. The finding that apigenin, by activating the anti-oxidant response, reduced PEL cell survival is quite surprising, since it usually elevated oxidant species to induce cancer cell death [ 39 ]. However, it is well known that ROS levels need to be finely regulated since either their increase or their reduction reduce cell survival [ 23 ].…”
Section: Discussionmentioning
confidence: 99%
“…p53 is strongly involved in the control of ROS level, since it can have both pro-oxidant and anti-oxidant properties that can be mediated by the inhibition or the activation of catalase activity [ 38 ]. The finding that apigenin, by activating the anti-oxidant response, reduced PEL cell survival is quite surprising, since it usually elevated oxidant species to induce cancer cell death [ 39 ]. However, it is well known that ROS levels need to be finely regulated since either their increase or their reduction reduce cell survival [ 23 ].…”
Section: Discussionmentioning
confidence: 99%
“…The anticancer activities of flavones apigenin and luteolin in ovarian cancer cell lines (A2780, OVCAR-3 and SKOV-3) were also related to the changes in ROS signaling, as well as to the promotion of apoptosis [82,83]. Moreover, apigenin activated apoptosis also in human cervical cancer-derived cell lines including HeLa (human papillomavirus/HPV 18-positive), SiHa (HPV 16-positive), CaSki (HPV 16 and HPV 18-positive), and C33A (HPV-negative) cells due to increased ROS generation and launched mitochondrial apoptotic pathways [84]. Flavone chrysin was reported to augment ROS and lipid peroxidation levels, leading to the death of choriocarcinoma (JAR and JEG3) [85], bladder cancer [86] and ovarian cancer (ES2 and OV90) cells [87].…”
Section: Flavonoids In Oxidative Stressmentioning
confidence: 96%
“…These results show that apigenin had a strong and selective anti-tumor effect on cervical cancer cells immortalized by infected with human papilloma virus, especially HPV16 and HPV18. These results indicate that apigenin has potential to be developed as therapeutic agent for (HPV) 16, HPV 18, and HPV 16 and 18 indicating its potential to be a powerful candidate in developing therapeutic agent for all cervical cancer types [162]. Apigenin enhances the inhibitory effect of IFN-α on cell viability in HeLa cancer cells but did not exhibit an effect on cell proliferation and apoptosis in HeLa cancer cells [163].…”
Section: 0 Effect Of Apigenin In Various Human Cancersmentioning
confidence: 99%