Oxidatively Damaged DNA/Oxidative Stress in Children with Celiac Disease

Szaflarska-Popławska, Anna; Siomek, Agnieszka; Czerwionka-Szaflarska, Mieczysława; Gackowski, Daniel; Różalski, Rafał; Guz, Jolanta; Szpila, Anna; Zarakowska, Ewelina; Oliński, Ryszard

doi:10.1158/1055-9965.epi-10-0295

Cited by 38 publications

(35 citation statements)

References 39 publications

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“…While comet assay or other methods used by other studies may be more direct measures of DNA damage, 8-OH-dG is an established marker of oxidative DNA damage and has been used in many studies of children (Dziaman et al, 2007; Svecova et al, 2009, Szaflarska-Poplawska et al, 2010). In this study, we did not monitor the extent of air pollution or ETS, which have been found to affect 8-OH-dG concentrations (Svecova et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Association of blood lead levels with urinary F2-8α isoprostane and 8-hydroxy-2-deoxy-guanosine concentrations in first-grade Uruguayan children

Roy

Queirolo

Peregalli

et al. 2015

Environmental Research

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Oxidative stress (OS) is a potential molecular mechanism for lead-induced toxicities, yet, we have limited understanding of the relation between low-level lead (Pb) exposure and OS, especially in children. This cross-sectional study examines the association between blood lead level (BLL) and two OS markers—urinary F2-8α isoprostane or isoprostane (a marker of lipid peroxidation) and 8-hydroxy-2-deoxy-Guanosine or 8-OH-dG (a marker of DNA damage) in 211 children, aged 5–8 years, from Montevideo, Uruguay. The role of dietary intakes of vitamin C and zinc in modifying the relation between BLL and OS was also examined. The mean (SD) BLL of the study children was 4.7 (2.2) μg/dL, with 30.2% children having BLL ≥5 μg/dL, the current reference level set by the US Centre for Disease Control for identifying, monitoring and management of children with elevated BLL. In covariate-adjusted analysis, there was a weak positive association between BLL and urinary isoprostane (adjusted for specific gravity) [β = 0.09, p< 0.1]. No association was found between children’s BLL and urinary 8-OH-dG. Interactions between dietary intakes of vitamin C or zinc and BLL on OS biomarkers were not consistent. However, when BLL and vitamin C or BLL and zinc were modeled together, BLL was independently associated with isoprostane concentration [β = 0.10, p< 0.05] but vitamin C or zinc intake was not. These findings suggest that there may be a potential adverse effect of BLL on OS in children with low-level Pb exposure. There is a need to study the effects of Pb on other OS measures, as well as the role of OS in mediating low-level Pb toxicity on functional outcomes.

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Section: Discussionmentioning

confidence: 99%

Association of blood lead levels with urinary F2-8α isoprostane and 8-hydroxy-2-deoxy-guanosine concentrations in first-grade Uruguayan children

Roy

Queirolo

Peregalli

et al. 2015

Environmental Research

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“…Changes in vitamin E and antioxidant enzyme activities were observed also in circulating cells and plasma of patients [49,50,51,52,53,54,55] (Table 1). A decreased expression of the antioxidant and anti-inflammatory enzymes PON1 and PON3 mRNA was reported by Rothem et al in intestinal biopsy of celiac patients [56].…”

Section: Molecular Mechanisms On the Toxic Effects Of Glutenmentioning

confidence: 97%

Celiac Disease, Inflammation and Oxidative Damage: A Nutrigenetic Approach

et al. 2012

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Celiac disease (CD), a common heritable chronic inflammatory condition of the small intestine caused by permanent intolerance to gluten/gliadin (prolamin), is characterized by a complex interplay between genetic and environmental factors. Developments in proteomics have provided an important contribution to the understanding of the biochemical and immunological aspects of the disease and the mechanisms involved in toxicity of prolamins. It has been demonstrated that some gliadin peptides resistant to complete proteolytic digestion may directly affect intestinal cell structure and functions by modulating gene expression and oxidative stress. In recent years, the creation of the two research fields Nutrigenomics and Nutrigenetics, has enabled the elucidation of some interactions between diet, nutrients and genes. Various dietary components including long chain ω-3 fatty acids, plant flavonoids, and carotenoids have been demonstrated to modulate oxidative stress, gene expression and production of inflammatory mediators. Therefore their adoption could preserve intestinal barrier integrity, play a protective role against toxicity of gliadin peptides and have a role in nutritional therapy of celiac disease.

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“…Children with celiac disease, whether or not they are on a gluten-free diet, exhibit elevated urinary biomarkers of DNA damage (Zaflarska-Popawska et al , 2010). Human colon carcinoma cells exposed to peptides extracted from wheat responded with a sharp increase in the GSSG/GSH ratio (ratio of oxidized to reduced glutathione), a well-established indicator of oxidative stress (Rivabene, 1999).…”

Section: Cancermentioning

confidence: 99%

Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance

Samsel¹,

Seneff²

2013

Interdisciplinary Toxicology

158

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Celiac disease, and, more generally, gluten intolerance, is a growing problem worldwide, but especially in North America and Europe, where an estimated 5% of the population now suffers from it. Symptoms include nausea, diarrhea, skin rashes, macrocytic anemia and depression. It is a multifactorial disease associated with numerous nutritional deficiencies as well as reproductive issues and increased risk to thyroid disease, kidney failure and cancer. Here, we propose that glyphosate, the active ingredient in the herbicide, Roundup®, is the most important causal factor in this epidemic. Fish exposed to glyphosate develop digestive problems that are reminiscent of celiac disease. Celiac disease is associated with imbalances in gut bacteria that can be fully explained by the known effects of glyphosate on gut bacteria. Characteristics of celiac disease point to impairment in many cytochrome P450 enzymes, which are involved with detoxifying environmental toxins, activating vitamin D3, catabolizing vitamin A, and maintaining bile acid production and sulfate supplies to the gut. Glyphosate is known to inhibit cytochrome P450 enzymes. Deficiencies in iron, cobalt, molybdenum, copper and other rare metals associated with celiac disease can be attributed to glyphosate's strong ability to chelate these elements. Deficiencies in tryptophan, tyrosine, methionine and selenomethionine associated with celiac disease match glyphosate's known depletion of these amino acids. Celiac disease patients have an increased risk to non-Hodgkin's lymphoma, which has also been implicated in glyphosate exposure. Reproductive issues associated with celiac disease, such as infertility, miscarriages, and birth defects, can also be explained by glyphosate. Glyphosate residues in wheat and other crops are likely increasing recently due to the growing practice of crop desiccation just prior to the harvest. We argue that the practice of “ripening” sugar cane with glyphosate may explain the recent surge in kidney failure among agricultural workers in Central America. We conclude with a plea to governments to reconsider policies regarding the safety of glyphosate residues in foods.

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Oxidatively Damaged DNA/Oxidative Stress in Children with Celiac Disease

Cited by 38 publications

References 39 publications

Association of blood lead levels with urinary F2-8α isoprostane and 8-hydroxy-2-deoxy-guanosine concentrations in first-grade Uruguayan children

Association of blood lead levels with urinary F2-8α isoprostane and 8-hydroxy-2-deoxy-guanosine concentrations in first-grade Uruguayan children

Celiac Disease, Inflammation and Oxidative Damage: A Nutrigenetic Approach

Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance

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