Oxide-supported atomically precise gold nanocluster for catalyzing Sonogashira cross-coupling

Sonogashira cross-coupling on the Au(1 1 1) and Au(1 0 0) facets of gold nanorod catalysts: Experimental and computational investigation

“…According to previous works, CeO 2 can lead to higher catalytic efficiency in carbonAcarbon coupling reactions (i.e., conversion and selectivity) of supported gold nanoclusters than other oxide supports (e.g., TiO 2 , SiO 2 , MgO) [15,16,32]. Free (unsupported) gold colloids are unstable at high temperatures (e.g., 100°C), as the water solution turns colorless and formation of black solids at 100°C is observed at the bottom of the flask for several hours (the black solids do not dissolve in the fresh water).…”

“…Here we use p-iodoanisole and phenylacetylene as reactants only for ease of quantification by 1 H NMR [15]. The mixture was stirred under N 2 at 150°C for 24 h as indicated in Table 1.…”

“…Over the past few decades, colloidal gold nanoparticles (NPs) have gained tremendous attention as catalysts for organic reactions such as selective oxidation, hydrogenation, and carbonAcarbon coupling reactions due to the robust and green nature of gold catalysts [10][11][12][13][14][15][16]. According to a previous work by Lambert et al, oxide-supported gold nanoparticles are active catalysts for Sonogashira cross-coupling reactions between iodobenzene (IB) and phenylacetylene (PA) [17].…”

Phosphine/phenylacetylide-ligated Au clusters for multicomponent coupling reactions

“…Recent success in the synthesis of atomically precise gold clusters has provided exciting opportunities to pursue the fundamental mechanistic understanding of heterogeneous catalysis [24]. For example, the catalytic efficiency and selectivity of the oxide-supported Au 25 (SR) 18 cluster (where ''-SR" represents the thiolate ligand) have been demonstrated in several reactions [24,25], including Ullmann homo-coupling and Sonogashira cross-coupling [26,27]. DFT calculations predict that both iodobenzene and phenylacetylene reactants can adsorb onto the open facets of Au 25 (SR) 18 clusters to react and yield final products [27].…”

Understanding Selective Hydrogenation of α,β-Unsaturated Ketones to Unsaturated Alcohols on the Au25(SR)18 Cluster

“…36−38 In addition, the Au 25 (SR) 18 structure has two facets, where three Au atoms from the staple motifs are well exposed for reactant access. 26,28,31,33 Whether or not H 2 activation and selective CO binding on the Au 25 (SR) 18 cluster is responsible for its 100% selectivity toward the unsaturated alcohol is an interesting question to answer. The well-defined compositions and structures of the atomically precise gold nanoclusters provide a valuable platform to reveal the underlying mechanism.…”