Oxidized Bletilla rhizome polysaccharide-based aerogel with synergistic antibiosis and hemostasis for wound healing

Qing, Yan; Long, Xiaoyan; Zhang, Puxiang; Wei, Lei; Sun, Dequn; Ye, Xiaoying

doi:10.1016/j.carbpol.2022.119696

Cited by 40 publications

(16 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The material was fabricated following the freeze-drying method, and a mouse model of total skin defect was studied. The dressing was found to reduce inflammation, promote angiogenesis, and facilitate the wound-healing process [32] (Figure 3). Carbon aerogels are chemically stable materials characterized by high hardness and melting points.…”

Section: Aerogelsmentioning

confidence: 99%

“…A: scanning electron microscopy images of porous aerogels; B: antibacterial activity of aerogels against E. coli and S. aureus ; C: application to a mouse model of total skin defect to promote wound healing and D wound healing rate statistics (comparison with nano silver dressing). Reproduced with permission from 32 . ©2022 Elsevier Ltd. All rights reserved.…”

Section: Figurementioning

confidence: 99%

See 1 more Smart Citation

Recent advances in the medical applications of hemostatic materials

Yu¹,

Wang²,

Liu³

et al. 2023

Theranostics

View full text Add to dashboard Cite

Bleeding caused by trauma or surgery is a serious health problem, and uncontrollable bleeding can result in death. Therefore, developing safe, effective, and convenient hemostatic materials is important. Active hemostatic agents currently used to investigate the field of hemostasis are divided into four broad categories: natural polymers, synthetic polymers, inorganic materials, and metal-containing materials. Hemostatic materials are prepared in various forms for wound care applications based on the active ingredients used. These materials include nanofibers, gels, sponges, and nanoparticles. Hemostatic materials find their applications in the field of wound care, and they are also used for hemostasis during malignant tumor surgery. Prompt and effective hemostasis can reduce the possibility of the spread of tumor cells with blood. This review discusses the outcomes of current research conducted in the field and the problems persisting in the field of developing hemostatic materials. The review also presents a platform for the further development of hemostatic materials. Bleeding caused by trauma or surgery is a serious health problem, and uncontrollable bleeding can result in death. Therefore, developing safe, effective, and convenient hemostatic materials is important. Active hemostatic agents currently used to investigate the field of hemostasis are divided into four broad categories: natural polymers, synthetic polymers, inorganic materials, and metal-containing materials. Hemostatic materials are prepared in various forms for wound care applications based on the active ingredients used. These materials include nanofibers, gels, sponges, and nanoparticles. Hemostatic materials find their applications in the field of wound care, and they are also used for hemostasis during malignant tumor surgery. Prompt and effective hemostasis can reduce the possibility of the spread of tumor cells with blood. This review discusses the outcomes of current research conducted in the field and the problems persisting in the field of developing hemostatic materials. The review also presents a platform for the further development of hemostatic materials.

show abstract

Section: Aerogelsmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Recent advances in the medical applications of hemostatic materials

Yu¹,

Wang²,

Liu³

et al. 2023

Theranostics

View full text Add to dashboard Cite

show abstract

“…The study reported that hybrid aerogel had ability to close a wound and had antibacterial activity against S. aureus and K. pneumoniae [ 85 ]. More recently, Yan et al discovered oxidized Bletilla polysaccharide Schift Base (ORBPS)/PVA aerogel from combination of freeze-drying and crosslinking demonstrated good antibacterial as well as hemostatic properties for wound healing [ 103 ].…”

Section: Biomedical Applications Of Aerogelmentioning

confidence: 99%

Emerging Trends in Nanotechnology: Aerogel-Based Materials for Biomedical Applications

et al. 2023

View full text Add to dashboard Cite

At present, aerogel is one of the most interesting materials globally. The network of aerogel consists of pores with nanometer widths, which leads to a variety of functional properties and broad applications. Aerogel is categorized as inorganic, organic, carbon, and biopolymers, and can be modified by the addition of advanced materials and nanofillers. Herein, this review critically discusses the basic preparation of aerogel from the sol–gel reaction with derivation and modification of a standard method to produce various aerogels for diverse functionalities. In addition, the biocompatibility of various types of aerogels were elaborated. Then, biomedical applications of aerogel were focused on this review as a drug delivery carrier, wound healing agent, antioxidant, anti-toxicity, bone regenerative, cartilage tissue activities and in dental fields. The clinical status of aerogel in the biomedical sector is shown to be similarly far from adequate. Moreover, due to their remarkable properties, aerogels are found to be preferably used as tissue scaffolds and drug delivery systems. The advanced studies in areas including self-healing, additive manufacturing (AM) technology, toxicity, and fluorescent-based aerogel are crucially important and are further addressed.

show abstract

“…Cutaneous injury, one of the most frequently encountered clinical manifestations, has become a global public health problem . A contaminated or dirty-infected wound usually leads to bacterial infiltration, resulting in local infection, slow wound repair, and even systemic sepsis. , During wound healing, uncontrollable bleeding and wound infection are two crucial factors that lead to delayed healing and even death. , Local application of antibiotics can be used as the initial treatment for superficial wound infections. , However, excessive usage of antibiotics and rapid activation of bacterial resistance genes have led to strong resistance of pathogens against traditional antibiotics. , Meanwhile, antihemorrhagic drugs such as noradrenaline and thrombase exert little antibacterial activity. − Therefore, it is highly imperative to develop drugs with broad-spectrum antibacterial activity and notable hemostatic effects for wound management …”

Section: Introductionmentioning

confidence: 99%

“…10−13 Therefore, it is highly imperative to develop drugs with broad-spectrum antibacterial activity and notable hemostatic effects for wound management. 14 Herbal medicines have attracted enormous attention for treating the common cold, chronic disease, respiratory disease, and cardiovascular disease due to their multiple pharmacological functions including antibacterial, anti-inflammatory, antioxidation, and antiviral effects. 15−17 Especially in developing countries with poor healthcare resources, herbal medicines have increasing popularity and acceptability in the belief of the safety, cheapness, and common availability of natural products.…”

Section: ■ Introductionmentioning

confidence: 99%

Herbal Medicine-Inspired Carbon Quantum Dots with Antibiosis and Hemostasis Effects for Promoting Wound Healing

Zhu,

Zhou,

Yan

et al. 2024

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Bleeding and bacterial infections are crucial factors affecting wound healing. The usage of herbal medicine-derived materials holds great potential for promoting wound healing. However, the uncertain intrinsic effective ingredients and unclear mechanism of action remain great concerns. Herein, inspired by the herbal medicine Ligusticum wallichii, we reported the synthesis of tetramethylpyrazine-derived carbon quantum dots (TMP-CQDs) for promoting wound healing. Of note, the use of TMP as the precursor instead of L. wallichii ensured the repeatability and homogeneity of the obtained products. Furthermore, TMP-CQDs exhibited high antibacterial activity. Mechanically, TMP-CQDs inhibited the DNA repair, biosynthesis, and quorum sensing of the bacteria and induced intracellular reactive oxygen species (ROS). Moreover, TMP-CQDs could accelerate blood coagulation through activating factor VIII and promoting platelet aggregation. Effective wound healing was achieved by using TMP-CQDs in the Staphylococcus aureus-infected mouse skin wound model. This study sheds light on the development of herbal medicine-inspired materials as effective therapeutic drugs.

show abstract

Oxidized Bletilla rhizome polysaccharide-based aerogel with synergistic antibiosis and hemostasis for wound healing

Cited by 40 publications

References 61 publications

Recent advances in the medical applications of hemostatic materials

Recent advances in the medical applications of hemostatic materials

Emerging Trends in Nanotechnology: Aerogel-Based Materials for Biomedical Applications

Herbal Medicine-Inspired Carbon Quantum Dots with Antibiosis and Hemostasis Effects for Promoting Wound Healing

Contact Info

Product

Resources

About