Oxidized cyclodextrin-functionalized injectable gelatin hydrogels as a new platform for tissue-adhesive hydrophobic drug delivery

Thi, Thai Thanh Hoang; Lee, Yunki; Ryu, Seung Bae; Sung, Hak‐Joon

doi:10.1039/c7ra04137c

Cited by 46 publications

(25 citation statements)

References 35 publications

(46 reference statements)

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Section: Recent Advances In Hydrogel Based Targeted Drug Deliverymentioning

confidence: 99%

“…It is easier to perceive that they are under smaller pressure inside the body as drugs but can still maintain the required shape and dimensions. Reprinted with permission from ref . Copyright 2017 Royal Society of Chemistry.…”

Section: Improvement Of Hydrogel Effectiveness For Drug Deliverymentioning

confidence: 99%

“…(A, B) Hydrogels exhibiting adhesive behavior in situ that are composed upon the combination of the reactions and therapeutic release. Reproduced from ref under terms of Creative Commons license. Published 2017 Royal Society of Chemistry.…”

Section: Introductionmentioning

confidence: 99%

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Review of Recent Advances and Their Improvement in the Effectiveness of Hydrogel-Based Targeted Drug Delivery: A Hope for Treating Cancer

Sonker

Bajpai

Khan

et al. 2021

ACS Appl. Bio Mater.

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Using hydrogels for delivering cancer therapeutics is advantageous in pharmaceutical usage as they have an edge over traditional delivery, which is tainted due to the risk of toxicity that it imbues. Hydrogel usage leads to the development of a more controlled drug release system owing to its amenability for structural metamorphosis, its higher porosity to seat the drug molecules, and its ability to shield the drug from denaturation. The thing that makes its utility even more enhanced is that they make themselves more recognizable to the body tissues and hence can stay inside the body for a longer time, enhancing the efficiency of the delivery, which otherwise is negatively affected since the drug is identified by the human immunity as a foreign substance, and thus, an attack of the immunity begins on the drug injected. A variety of hydrogels such as thermosensitive, pH-sensitive, and magnetism-responsive hydrogels have been included and their potential usage in drug delivery has been discussed in this review that aims to present recent studies on hydrogels that respond to alterations under a variety of circumstances in “reducing” situations that mimic the microenvironment of cancerous cells.

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Section: Recent Advances In Hydrogel Based Targeted Drug Deliverymentioning

confidence: 99%

Section: Improvement Of Hydrogel Effectiveness For Drug Deliverymentioning

confidence: 99%

See 1 more Smart Citation

Review of Recent Advances and Their Improvement in the Effectiveness of Hydrogel-Based Targeted Drug Delivery: A Hope for Treating Cancer

Sonker

Bajpai

Khan

et al. 2021

ACS Appl. Bio Mater.

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show abstract

“…Among them, Horseradish peroxidase-catalyzed hydrogels were formed in the mildest conditions and showed tunable mechanical properties and biocompatibility [6]. These hydrogels were applied successfully to incorporate various cell lines and sustainably release many types of drugs [3,7,8]. However, this reaction used hydrogen peroxide as a strongly oxidizing agent, which easily interacts with bioactive compounds, especially polyphenols, and thus leads to inactivate them.…”

Section: Introductionmentioning

confidence: 99%

Supramolecular Gels Incorporating Cordyline terminalis Leaf Extract as a Polyphenol Release Scaffold for Biomedical Applications

Thi

Tran

Thi

et al. 2021

IJMS

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Cordyline terminalis leaf extract (aqCT) possesses abundant polyphenols and other bioactive compounds, which are encapsulated in gelatin–polyethylene glycol–tyramine (GPT)/alpha-cyclodextrin (α-CD) gels to form the additional functional materials for biomedical applications. In this study, the gel compositions are optimized, and the GPT/α-CD ratios equal to or less than one half for solidification are found. The gelation time varies from 40.7 min to 5.0 h depending on the increase in GPT/α-CD ratios and aqCT amount. The aqCT extract disturbs the hydrogen bonding and host–guest inclusion of GPT/α-CD gel networks, postponing the gelation. Scanning electron microscope observation shows that all gels with or without aqCT possess a microarchitecture and porosity. GPT/α-CD/aqCT gels could release polyphenols from 110 to 350 nmol/mL at the first hour and sustainably from 5.5 to 20.2 nmol/mL for the following hours, which is controlled by feeding the aqCT amount and gel properties. GPT/α-CD/aqCT gels achieved significant antioxidant activity through a 100% scavenging DPPH radical. In addition, all gels are non-cytotoxic with a cell viability more than 85%. Especially, the GPT3.75α-CD10.5aqCT gels with aqCT amount of 3.1–12.5 mg/mL immensely enhanced the cell proliferation of GPT3.75α-CD10.5 gel without extract. These results suggest that the inherent bioactivities of aqCT endowed the resulting GPT/α-CD/aqCT gels with effective antioxidant and high biocompatibility, and natural polyphenols sustainably release a unique platform for a drug delivery system or other biomedical applications.

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“…These soft materials have many potential applications in the fields of environmental, agricultural, biomedical and tissue engineering. Among the various stimuli‐responsive hydrogels, pH‐responsive smart hydrogels are especially considered for their application in wound dressing, drug and protein delivery systems, sensors, actuators, smart windows and robotics . However, the application of hydrogels is often limited by their poor mechanical properties in their swollen state.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of multifunctional high strength, highly swellable, stretchable and self‐healable pH‐responsive ionic double network hydrogels

Dixit

Bag

Sharma

et al. 2018

Polymer International

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The multifunctional double network (DN) soft hydrogels reported here are highly swellable and stretchable pH‐responsive smart hydrogel materials with sufficient strength and self‐healing properties. Such multifunctional hydrogels are achieved using double crosslinking structures with multiple physical and chemical crosslinks. They consist of a copolymer network of acrylamide (AM) and sodium acrylate (Na‐AA) and other reversible network of poly(vinyl alcohol)–borax complex. They were characterized by Fourier transform IR analysis and studied for their hydrogen bonding and ionic interaction. The degree of equilibrium swelling was observed to be as high as 5959% (at pH 7.0) for a hydrogel with AM/Na‐AA = 25/75 wt% in the network (GS‐6 sample). The highest degree of swelling was observed to be 6494% at pH 8.5. The maximum tensile strength was measured to be 1670, 580 and 130 kPa for a DN hydrogel (GS‐2 sample: AM/Na‐AA =75/25 wt% with 20, 40 and 60 wt% water content, respectively). The self‐healing efficiency was estimated to be 69% for such a hydrogel. These multifunctional DN hydrogels with amalgamation of many functional properties are unique in hydrogel materials and such materials may find applications in sensors, actuators, smart windows and biomedical applications. © 2018 Society of Chemical Industry

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Oxidized cyclodextrin-functionalized injectable gelatin hydrogels as a new platform for tissue-adhesive hydrophobic drug delivery

Abstract: Dual-functional injectable gelatin-based hydrogels utilizing oxidized β-cyclodextrin show high adhesiveness and hydrophobic drug supply.

Cited by 46 publications

References 35 publications

Review of Recent Advances and Their Improvement in the Effectiveness of Hydrogel-Based Targeted Drug Delivery: A Hope for Treating Cancer

Review of Recent Advances and Their Improvement in the Effectiveness of Hydrogel-Based Targeted Drug Delivery: A Hope for Treating Cancer

Supramolecular Gels Incorporating Cordyline terminalis Leaf Extract as a Polyphenol Release Scaffold for Biomedical Applications

Synthesis of multifunctional high strength, highly swellable, stretchable and self‐healable pH‐responsive ionic double network hydrogels

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