Oxidized LDL and thickness of carotid intima-media are associated with coronary atherosclerosis in middle-aged men: lower levels of oxidized LDL with statin therapy

Vasankari, Tommi; Ahotupa, Markku; Toikka, Jyri; Mikkola, Jorma; Irjala, Kerttu; Pasanen, Paavo; Neuvonen, Kari; Raitakari, Olli T.; Viikari, Jorma

doi:10.1016/s0021-9150(00)00573-6

Cited by 98 publications

(65 citation statements)

References 39 publications

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“…The level of plasma OxLDL in the AS group was significantly higher than those in the control group (Fig. 1b, p<0.05 compared with control), consistent with others (Vasankari et al 2001). Different results show the different level of circulating anti-Hsp70 antibody in cardiovascular disease.…”

Section: Correlation Between Plasma Anti-hsp70 Autoantibodies and Oxlsupporting

confidence: 86%

Evidence of a role for both anti-Hsp70 antibody and endothelial surface membrane Hsp70 in atherosclerosis

Leng

Wang²,

Pang³

et al. 2013

Cell Stress and Chaperones

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Although previous studies have shown that autoantigens such as Hsps have been implicated by induction of an autoimmune process in the development of atherosclerosis, the exact role of anti-Hsp70 antibody in atherosclerosis is unknown. In the present study, the levels of anti-Hsp70 autoantibodies and oxidized low density lipoprotein (OxLDL) were all significantly increased, and they were strongly correlated in an atherosclerosis model. After the endothelial cells were incubated with 20 μg/mL OxLDL for 12 h at 37°C and followed by 90 min recovery, Hsp70

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Section: Correlation Between Plasma Anti-hsp70 Autoantibodies and Oxlsupporting

confidence: 86%

Evidence of a role for both anti-Hsp70 antibody and endothelial surface membrane Hsp70 in atherosclerosis

Leng

Wang²,

Pang³

et al. 2013

Cell Stress and Chaperones

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show abstract

“…It may be argued that the analysis of lymph nodes more adjacent to the aorta reflects the traveling of T cells and DCs from atherosclerotic lesions more accurately. However, atherosclerosis is a systemic disease and oxLDL is a systemically detectable molecule, [17][18][19] so uptake of oxLDL by antigen-presenting cells may not be locally restricted. In The body weights before and after feeding did not differ with regard to the genotypes (meanϮSD; nϭ7 per group).…”

Section: Ccr7 Deficiency Increases Infiltration Of Dcs and T Cells Inmentioning

confidence: 99%

Chemokine Receptor 7 Knockout Attenuates Atherosclerotic Plaque Development

et al. 2010

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Background-Atherosclerosis is a systemic inflammatory disease characterized by the formation of atherosclerotic plaques. Both innate immunity and adaptive immunity contribute to atherogenesis, but the mode of interaction is poorly understood. Chemokine receptor 7 (CCR7) is critically involved in the transition from innate to adaptive immune activation by coordinating the migration to and positioning of antigen-presenting dendritic cells and T cells in secondary lymphoid organs. More recently, it was shown that CCR7 is also responsible for T-cell migration into inflamed tissues and T-cell egress from these tissues via the afferent lymph. Thus, we investigated the influence of a systemic CCR7 deficiency on atherogenesis in atherosclerosis-prone low-density lipoprotein receptor (ldlr) knockout mice. Methods and Results-CCR7 deficiency resulted in reduced atherosclerotic plaque development. CCR7Ϫ/Ϫ T cells showed impaired entry and exit behavior from atherosclerotic lesions. Oxidized low-density lipoprotein, a key molecule for atherogenesis with antigenic features, was used to pulse dendritic cells and to expand T cells ex vivo. Adoptive transfer of C57BL/6 wild-type T cells but not ccr7 Key Words: atherosclerosis Ⅲ lipids Ⅲ immune system Ⅲ lymphocytes A therosclerosis is a chronic systemic inflammatory disease characterized by the accumulation of lipids in the arterial wall, frequently leading to myocardial infarction, stroke, and sudden death. 1 In early atherogenesis, monocytes are recruited into the arterial vessel wall, where they differentiate into macrophages, take up cholesterol deposits (mainly oxidized low-density lipoproteins [oxLDL]), become foam cells, and form the initial atherosclerotic lesion. At the same time, secretion of inflammatory cytokines results in further recruitment of monocytes, T cells, and cells of the vessel wall into the lesion, thereby driving atherosclerotic plaque growth and maturation. Although there is profound evidence for the importance of both innate and adaptive immunity for atherosclerotic plaque development, 2 the transition processes and mode of interaction between these immune responses remain unclear. However, accumulating evidence indicates that oxLDL may represent a connecting piece between innate and adaptive immunity in this setting. In this regard, different groups were able to show that stimulation with oxLDL led not only to dendritic cell (DC) maturation 3,4 but also to clonal T-cell proliferation and differentiation into proinflammatory T helper (Th) 1 cells. 5,6 Clinical Perspective on p 1628The classic activation of adaptive immunity takes place in secondary lymphoid organs (SLOs) where antigen presentation by DCs to naïve T cells results in activation and functional differentiation of these T cells. The C-Cchemokine receptor type 7 (CCR7) has been described to be crucially involved in several fundamental processes shaping the structural and functional organization of the adaptive immune system. 7 CCR7 is regarded as a key receptor in the coordinated migrati...

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“…Carotid IMT is a validated measure of carotid atherosclerosis. It is well established that carotid atherosclerosis, serves as an independent surrogate marker for CHD (Vasankari et al, 2001) and CVD (van Tits et al, 2006). Nevertheless, in the present study it was preferred to estimate the degree of carotid stenosis with a more direct approach, because this is more readily available in most hospital settings and because there is an obvious relation with clinical symptoms and signs.…”

Section: Discussionmentioning

confidence: 99%

“…Besides, it represents a reliable method with sufficient reproducibility and it is practically the method of choice when evaluated patients candidate for endarterectomy or angioplasty. Evaluating carotid stenosis in turn, is an established method for estimating coronary risk (Vasankari et al, 2001) and cardiovascular risk (van Tits et al, 2006). Other parameters of vessel wall function, such as IMT and plaque morphology, even if clearly associated with cardiovascular risk in the literature, require well equipped laboratory and are not readily available in our hospital.…”

Section: Discussionmentioning

confidence: 99%

“…Oxidized LDL levels (Papathanasiou et al, 2008), autoantibodies against epitopes of oxLDL (Papathanasiou et al, 2008) and oxLDL:LDL ratio (Vasankari et al, 2001) are independently associated with increased risk for coronary atheromatosis and ischemic heart disease. Increased levels of oxLDL (Ehara et al, 2001) and MDA-LDL (Holvoet et al, 1999) in such cases are related to plaque instability.…”

Section: Discussionmentioning

confidence: 99%

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