Oxidized LDL: As a risk factor for cardiovascular disease in renal transplantation

Soltani, Adele; Argani, Hassan; Rahimipour, Hooman; Soleimani, Fateme; Rahimi, F; Kazerouni, Faranak

doi:10.5935/0101-2800.20160023

Cited by 5 publications

(5 citation statements)

References 22 publications

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“…24 Lack of glycemic control activates hepatic mechanisms that rise lipoprotein synthesis, increasing LDL levels, and reducing HDL levels. These factors are strongly associated with cardiovascular risk, 23,25 which supports the metabolic results of this study. Results similar to these were found in our previous study, revealing that a more meticulous analysis of biochemical components allows a better comprehension of the MS progression status in the elderly population.…”

Section: Discussionsupporting

confidence: 89%

“…The LDL role associated with cardiovascular impairment may trigger CVD development, and this association may be enhanced by factors such as a smoking habit, DM, and hypertension. 23,25,31 DM was identified in this study as predictive of high cardiovascular risk and is one of the factors involved in the MS process. Some studies cite MS as a predictor for the DM diagnosis.…”

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

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<p>Impact of Metabolic Syndrome Components in High-Risk Cardiovascular Disease Development in Older Adults</p>

Barbalho

Stival

Lima

et al. 2020

CIA

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Objective: Analyze the influence between the components of metabolic syndrome and the independent risk for cardiovascular disease (CVD) in the elderly. Methods: A descriptive cross-sectional study was carried out with 205 older adults from a primary healthcare unit of the Federal District, Brazil. The cardiovascular risk was determined by the Framingham Risk Score (FRS). The National Cholesterol Evaluation Program for Adult Treatment Panel III 2001 (NCEP-ATP III) criteria were considered to analyze metabolic syndrome (MS) diagnoses. Results: There was a strong association between MS and high cardiovascular risk (OR = 8.86). The univariate analysis main findings revealed that male gender, diabetes, smoking habit, systolic blood pressure, HDL level, high blood glucose, glycated hemoglobin, and LDL level were associated with high cardiovascular risk. FRS increases significantly with the presence of four or more MS components (by 30%, if 4 components are present, and by 40%, if 5 components) when compared with the presence of three or fewer components (P <0.001). A logistic regression analysis of high-risk predictors was described to reduce the effects of confounding and bias factors. Conclusion: The identification of MS associated with high FRS values represents a cascading of adverse effects on the population's aging process.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 94%

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<p>Impact of Metabolic Syndrome Components in High-Risk Cardiovascular Disease Development in Older Adults</p>

Barbalho

Stival

Lima

et al. 2020

CIA

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“…VSMC proliferation is one of the major contributors to AS, and the associated risk factors remain the focus of current research. For example, ox-LDL is associated with AS, and is formed as a result of ox-LDL oxidation (32)(33)(34). In addition, further research has focused on improving and preventing the development of AS.…”

Section: Discussionmentioning

confidence: 99%

miR‑129‑5p inhibits oxidized low‑density lipoprotein‑induced A7r5 cell viability and migration by targeting HMGB1 and the PI3k/Akt signaling pathway

Jiang

Gong

2022

Exp Ther Med

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The mechanisms underlying gene therapy for the treatment of cardiovascular diseases remain to be elucidated. microRNAs (miRs) have been recognized as key regulators in vascular smooth muscle cells, which are involved in the formation of atherosclerosis. The present study aimed to explore the role of miR-129-5p in the regulation of high-mobility group box 1 protein (HMGB1) and the PI3k/Akt signaling pathway, and further explore the role of miR-129-5p in the viability and migration of A7r5 cells induced by oxidized low-density lipoprotein (ox-LDL). Cell viability, viability and migration were determined using Cell Counting Kit-8, colony formation, wound healing and Transwell assays. The expression levels of miR-129-5p and HMGB1 were detected using reverse transcription-quantitative PCR and western blotting. A dual-luciferase assay was used to confirm the association between miR-129-5p and HMGB1. RT-qPCR results in the present study demonstrated that the expression levels of miR-129-5p in A7r5 cells induced by ox-LDL were significantly decreased, compared with the control cells. Moreover, the viability and migration of A7r5 cells induced by ox-LDL were increased compared with control group. Western blot and RT-qPCR results showed that miR-129-5p decreased the expression of HMGB1 in A7r5 cells compared with control group. The present results demonstrated that miR-129-5p inhibited the viability, viability and migration of A7r5 cells induced by ox-LDL, and directly targeted HMGB1 to regulate the PI3k/Akt signaling pathway. In conclusion, miR-129-5p inhibited the PI3k/Akt signaling pathway by directly targeting HMGB1, and reduced the viability, viability and migration of A7r5 cells induced by ox-LDL.

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“…Vascular smooth muscle cell proliferation is one of the major contributors to atherosclerosis, thus its risk factors are being extensively studied. One of them is ox-LDL, a result of ox-LDL oxidation [18,19,20]. In addition, efforts to improve and prevent atherosclerosis are continuing.…”

Section: Discussionmentioning

confidence: 99%

miR-129-5p inhibits oxidized low-density lipoprotein-induced A7r5 cells proliferation and migration through targeting HMGB1 involving a PI3K/Akt signal pathway

Jiang

Gong

2020

Preprint

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Background Currently, gene therapy for cardiovascular diseases has been widely concerned, but its mechanism is still unclear. Objective Recently miRNAs have been recognized as a key regulator in vascular smooth muscle cells (VSMCs) which involved in the formation of atherosclerosis. The aim of the study was to explore the role of miR-129-5p in regulation of HMGB1 involving a PI3K/Akt signal pathway as well as the proliferation and migration in A7r5 cells induced by ox-LDL. Methods Cell viability, proliferation and migration were conducted by CCK-8, colony formation, wound healing assay and transwell assay. The expressions of miR-129-5p and HMGB1 were detected by real-time quantitative-qPCR (RT-qPCR) and western blot. Luciferase assay was used to confirm that miR-129-5p directly targeted HMGB1. Results The expression of miR-129-5p in A7r5 cells induced by ox-LDL was significantly decreased in comparison with the control cells. Cell viability, proliferation and migration of A7r5 cells induced by ox-LDL were increased. MiR-129-5p could down-regulate the expression of HMGB1 in A7r5 cells. More studies showed that miR-129-5p could inhibit cell viability, proliferation on and migration of A7r5 cells induced by ox-LDL and target HMGB1 to regulate PI3K/Akt signal pathway. Conclusion miR-129-5p could inhibit PI3K/Akt signal pathway by target HMGB1 and further restrain the cell viability, proliferation and migration of A7r5 cells induced by ox-LDL.

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Oxidized LDL: As a risk factor for cardiovascular disease in renal transplantation

Cited by 5 publications

References 22 publications

<p>Impact of Metabolic Syndrome Components in High-Risk Cardiovascular Disease Development in Older Adults</p>

<p>Impact of Metabolic Syndrome Components in High-Risk Cardiovascular Disease Development in Older Adults</p>

miR‑129‑5p inhibits oxidized low‑density lipoprotein‑induced A7r5 cell viability and migration by targeting HMGB1 and the PI3k/Akt signaling pathway

miR-129-5p inhibits oxidized low-density lipoprotein-induced A7r5 cells proliferation and migration through targeting HMGB1 involving a PI3K/Akt signal pathway

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