Oxidized-LDL/β2-Glycoprotein I Complexes Are Associated With Disease Severity and Increased Risk for Adverse Outcomes in Patients With Acute Coronary Syndromes

Greco, Thomas; Conti-Kelly, Ann Marie; Anthony, Jeremy R.; Doyle, Robin; Boisen, Matthew L.; Kojima, Kensuke; Matsuura, Eiji; Lopez, Luis R.

doi:10.1309/ajcp88wvrdrdfbas

Cited by 64 publications

(48 citation statements)

References 38 publications

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“…An association between CAD and AMI with Other aPLs have been reported in previous studies (Shojaie and Jahromi, 2011;Jafarzadeh et al, 2011;Greco et al, 2010). …”

Section: Discussionsupporting

confidence: 53%

Anti-Phosphatidylserine Antibodies in Acute Myocardial Infarction

Jahromi¹,

Shojaei²,

Farjam³

et al. 2013

American Journal of Immunology

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Acute Myocardial Infarction (AMI) is the combined result of environmental factors and personal predispositions. Many factors play a role in AMI including anti-Phospholipid (aPL) antibodies, that may act in the induction of immunological response leading to the development of AMI. AntiPhosphatidylserine (PS) antibody is detected in various diseases like rheumatoid arthritis, systemic lupus erythematosus and anti-phospholipid antibody syndrome. The study of anti-PS antibody in AMI might shed light on etiologic mechanisms in the pathogenesis of acute coronary syndromes. This study was conducted to evaluate whether prevalence of anti-PS antibodies, in patients who had AMI and to analyze their relationship with traditional cardiovascular risk factors. The prevalence of anti-PS IgG and IgM in a well characterized group of patients with AMI as a case group and in age and sex matched healthy subjects as control group. Sera from two groups were tested to evaluate the presence of IgG and IgM isotypes to anti-PS by ELISA method. The frequencies of positive test for anti-PS IgG were 26.70 and 8.90% among patients and controls respectively with significant difference (p = 0.003). The anti-PS IgM frequencies were 12.20 and 1.10% in patients and the controls, with significant difference (p = 0.005). The findings of this study suggest that anti-PS antibodies seemed to play a role in AMI, independent risk factors for AMI, which may represent a link between autoimmunity and atherosclerosis in patients with AMI. Further studies with bigger sample size including patients with AMI and healthy people are recommended to explore the exact role of anti-PS antibodies in AMI.

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“…An association between CAD and AMI with Other aPLs have been reported in previous studies (Shojaie and Jahromi, 2011;Jafarzadeh et al, 2011;Greco et al, 2010). …”

Section: Discussionsupporting

confidence: 53%

Anti-Phosphatidylserine Antibodies in Acute Myocardial Infarction

Jahromi¹,

Shojaei²,

Farjam³

et al. 2013

American Journal of Immunology

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“…Recent studies have shown that the measurement of oxLDL/β2GPI complexes in patients with cardiovascular diseases provides a novel marker for those patients prone to or at risk for coronary heart disease [3].…”

mentioning

confidence: 99%

Effect of hormone replacement therapy on total serum anti-oxidant potential and oxidized LDL/.BETA.2-glycoprotein I complexes in postmenopausal women

et al. 2010

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“…Other aPLs have been reported to have association with CAD and AMI (Shojaie and Jahromi, 2011;Jafarzadeh et al, 2011;Greco et al, 2010;Urbanus et al, 2009;Jahromi et al, 2013b;2013c).…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study of Anti-Phosphatidyl Inositole Antibodies in Patients With Myocardial Infarction and Healthy Subjects

Jahromi¹

2014

American Journal of Immunology

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Immune system and inflamation is widely known to play a key role in the development and progression of cardiovascular diseases. Anti-Phospholipid (aPL) antibodies may act in the induction of immunological response leading to the development of Acute Myocardial Infarction (AMI). Anti-Phosphatidyl Inositole (PI) Antibody (Ab) has been seen in various diseases including rheumatoid arthritis, systemic lupus erythematosus and anti-phospholipid antibody syndrome. Although there are a few studies on the association of some autoantibodies with AMI, more epidemiological data are required to confirm their significance as independent risk factors in cardiovascular diseases. Moreover, the data on the relationship of autoantibodies with traditional risk factors of AMI is rare. The study of anti-PI Ab in AMI may lead to understand of etiology of ischemic heart disease. This study was conducted to determine whether prevalence of anti-PI Abs, in patients who had AMI and to analyze their association with traditional cardiovascular risk factors. The prevalence of anti-PI IgG and IgM in a well characterized group of patients with AMI as a case group and in age and sex matched healthy subjects as control group. Sera from the case and the control groups were tested to evaluate the presence of IgG and IgM isotypes to anti-PI by ELISA method. The prevalence of anti-PI IgG and also IgM in the case group resulted significantly higher than in the control group with AMI (p<0.005). The findings of this study suggest that anti-PI Abs seemed to have a role in AMI independent risk factors for AMI and may represent a link between autoimmunity and atherosclerosis in patients with AMI. Comprehensive studies are recommended to explore the exact role of anti-PI Abs in AMI.

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Oxidized-LDL/β2-Glycoprotein I Complexes Are Associated With Disease Severity and Increased Risk for Adverse Outcomes in Patients With Acute Coronary Syndromes

Cited by 64 publications

References 38 publications

Anti-Phosphatidylserine Antibodies in Acute Myocardial Infarction

Anti-Phosphatidylserine Antibodies in Acute Myocardial Infarction

Effect of hormone replacement therapy on total serum anti-oxidant potential and oxidized LDL/.BETA.2-glycoprotein I complexes in postmenopausal women

A Comparative Study of Anti-Phosphatidyl Inositole Antibodies in Patients With Myocardial Infarction and Healthy Subjects

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