Oxidized low-density lipoprotein and intimal medial thickness in subjects with glucose intolerance—The Chennai Urban Rural Epidemiology Study-25

Gokulakrishnan, Kuppan; Deepa, R; Velmurugan, Kaliyaperumal; Radhakrishnan, Ramalingam; Karkuzhali, K; Mohan, Viswanathan

doi:10.1016/j.metabol.2006.10.002

Cited by 13 publications

(10 citation statements)

References 38 publications

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“…It was reported that serum ox-LDL levels are significantly higher in diabetic patients than healthy individuals [8,16,17]. In a study by Gokulakrishnan et al [18] the mean level of ox-LDL in diabetic patients was higher than subjects with impaired glucose tolerance. Our results showed the association in patients with different durations of diabetes.…”

Section: Discussionmentioning

confidence: 91%

Serum Oxidized‐LDL is Associated with Diabetes Duration Independent of Maintaining Optimized Levels of LDL‐Cholesterol

Nakhjavani

Khalilzadeh

Khajeali

et al. 2010

Lipids

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Oxidized low-density lipoprotein (ox-LDL) plays a key role in the progression of atherosclerosis and diabetes complications. The aim of this study was first, to evaluate the association between ox-LDL and diabetes duration, and second, to examine serum level of ox-LDL in patients with prolonged diabetes and a desirable LDL-cholesterol level. A total of 36 type-2 diabetic patients with a diabetes duration of more than 5 years, 36 newly diagnosed diabetic patients, and 36 age-, sex- and BMI-matched healthy participants were recruited. Healthy participants and newly diagnosed patients were not receiving any treatment. All patients with prolonged diabetes had desirable LDL-cholesterol levels (<100 mg/dL), according to the adult treatment panel-III guidelines. While LDL-cholesterol was significantly lower in patients with diabetes duration >5 years, in comparison to newly diagnosed patients (P < 0.01), ox-LDL was significantly higher in patients with prolonged diabetes (P < 0.001). The ox-LDL-to-LDL ratio was dramatically higher in patients with diabetes duration >5 years in comparison to newly diagnosed patients and healthy participants (P < 0.001). Ox-LDL was significantly associated with diabetes duration (r = 0.519, P = 0.001). In multivariate analysis, this association remained significant (beta = 0.501, P = 0.003) after adjustment for potential confounders. In conclusion, this study showed that the serum ox-LDL level increases with the length of diabetes, even though the patients' LDL-cholesterol level is maintained at a desirable level. Our findings highlight that possibly more attention should be focused on markers of oxidative stress in the management of lipids in diabetic patients.

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Section: Discussionmentioning

confidence: 91%

Serum Oxidized‐LDL is Associated with Diabetes Duration Independent of Maintaining Optimized Levels of LDL‐Cholesterol

Nakhjavani

Khalilzadeh

Khajeali

et al. 2010

Lipids

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“…Previous studies in India have only demonstrated associations with concurrent risk markers, and have shown that age, metabolic syndrome and diabetes are the risk factors most strongly related to CIMT (9,13,25). Additionally, waist-hip ratio, systolic blood pressure, total and LDL-cholesterol, oxidised LDL, insulin concentrations and insulin resistance, and C-reactive protein are correlated with CIMT in Indian populations (11,12,26). Mean CIMT values in the New Delhi Birth Cohort participants are generally higher than mean CIMT values smaller studies of individuals from North and West India (26, 27), but mean body weight, blood glucose, and total cholesterol were all higher in the New Delhi Birth Cohort participants.…”

Section: Discussionmentioning

confidence: 99%

“…Mean CIMT values in the New Delhi Birth Cohort participants are generally higher than mean CIMT values smaller studies of individuals from North and West India (26, 27), but mean body weight, blood glucose, and total cholesterol were all higher in the New Delhi Birth Cohort participants. Mean CIMT values were higher in older, North Indian participants with diabetes (1.3 mm [0.3]) from another study (11) but lower than older individuals from South India (12) and South Asian immigrants to the United Kingdom (28). …”

Section: Discussionmentioning

confidence: 99%

Predictors of carotid intima–media thickness and carotid plaque in young Indian adults: The New Delhi Birth Cohort

Khalil¹,

Huffman

Prabhakaran

et al. 2013

International Journal of Cardiology

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Background Carotid intima-media thickness (CIMT) and carotid plaques represent preclinical markers of atherosclerosis. We sought to describe predictors of CIMT and carotid plaques, including early life growth, in a young urban Indian cohort free of clinical cardiovascular disease (CVD). Methods In 2006-2009, we performed B-mode carotid ultrasound on 600 participants (mean [SD] age 36 [1.1] years; 45% women) from the New Delhi Birth Cohort to evaluate CIMT and carotid plaques (> 1mm). Height and weight were recorded at birth, 2 and 11 years of age. Data on CVD risk factors, anthropometry, medical history, socio-economic position, and lifestyle habits were collected in 1998-2002. Results Mean (SD) CIMT for men and women was 0.91 (0.12) and 0.86 (0.13) mm, respectively. Carotid plaque was present in 33% of men and 26% of women. Waist circumference in 1998-2002 was positively associated with CIMT (β coefficient 0.26 mm [0.17, 0.36] per SD) and carotid plaque (OR 1.27 [1.06,1.52] per SD) in 2006-2009. Higher triglycerides, PAI-1, insulin resistance, and diastolic blood pressure, metabolic syndrome, and lower HDL-cholesterol and physical activity predicted higher CIMT and/or plaque (p<0.05). Longer length at 2 years was associated with higher CIMT (p<0.05). These associations were attenuated after adjusting for adult waist circumference. Conclusions These are the first prospective data from India showing that early life growth, adult socio-demographics, and CVD risk factors predict future CIMT and /or carotid plaque. These relationships appear primarily mediated through central adiposity, highlighting the importance of maintaining a healthy weight in early adulthood to prevent CVD.

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“…Former studies have engaged that in diabetic as well as prediabetic subjects, hyperglycaemia modifi es LDL and makes it more fragile to oxidation [19] . Hence, the signifi cant lowering of oxidised LDL levels with constant total cholesterol concentrations might be attributed to improved blood glucose levels in the current study and suggest reduction in oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Improved Metabolic Control After 12-Week Dietary Intervention with Low Glycaemic Isomalt in Patients with Type 2 Diabetes Mellitus

et al. 2009

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The polyol isomalt (Palatinit) is a very low glycaemic sugar replacer. The effect of food supplemented with isomalt instead of higher glycaemic ingredients like sucrose and/or starch hydrolysates on metabolic control in patients with type 2 diabetes was examined in this open study. Thirty-three patients with type 2 diabetes received a diet with foods containing 30 g/d isomalt instead of higher-glycaemic carbohydrates for 12 weeks. Metformin and/or thiazolidindiones were the only concomitant oral antidiabetics allowed during the study. Otherwise, the participants maintained their usual diet during the test phase, but were instructed to refrain from additional sweetened foods. Before start, after 6 weeks and 12 weeks (completion of the study), blood samples were taken and analysed for clinical routine parameters, metabolic, and risk markers. Thirty-one patients completed the study. The test diet was well accepted and tolerated. After 12 weeks, significant reductions were observed for: glycosylated haemoglobin, fructosamine, fasting blood glucose, insulin, proinsulin, C-peptide, insulin resistance (HOMA-IR), and oxidised LDL (an atherosclerosis risk factor). In addition, significant lower nonesterified fatty acid concentrations were found in female participants. Routine blood measurements and blood lipids remained unchanged. The substitution of glycaemic ingredients by isomalt and the consequent on reduction of the glycaemic load within otherwise unchanged diet was accompanied by significant improvement in the metabolic control of diabetes. The present study is in agreement with findings of previous reported studies in human subjects demonstrating beneficial effects of low glycaemic diets on glucose metabolism in patients with diabetes mellitus type 2.

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Oxidized low-density lipoprotein and intimal medial thickness in subjects with glucose intolerance—The Chennai Urban Rural Epidemiology Study-25

Cited by 13 publications

References 38 publications

Serum Oxidized‐LDL is Associated with Diabetes Duration Independent of Maintaining Optimized Levels of LDL‐Cholesterol

Serum Oxidized‐LDL is Associated with Diabetes Duration Independent of Maintaining Optimized Levels of LDL‐Cholesterol

Predictors of carotid intima–media thickness and carotid plaque in young Indian adults: The New Delhi Birth Cohort

Improved Metabolic Control After 12-Week Dietary Intervention with Low Glycaemic Isomalt in Patients with Type 2 Diabetes Mellitus

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