Oxidized low-density lipoprotein induces secretion of interleukin-1β by macrophages via reactive oxygen species-dependent NLRP3 inflammasome activation

Jiang, Yugang; Wang, Mian; Huang, Kai; Zhang, Zhihui; Shao, Nan; Zhang, Yuanqi; Wang, Wenjian; Wang, Shenming

doi:10.1016/j.bbrc.2012.07.011

Cited by 143 publications

(99 citation statements)

References 24 publications

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“…Cholesterol crystals and oxidized low density lipoprotein (LDL) activate the "NLR family, pyrin domain containing 3" (NLRP3) inflammasome in human macro phages, thereby driving vascular repair, foam cell formation (10) and atherogenesis (7,(10)(11)(12). Moreover, the inflammasome adaptor molecule "apoptosis-associated speck-like protein with a caspase recruitment domain" (ASC) and caspase-1 were demonstrated to be critical for vascular inflammation, neointima formation and atherosclerosis in mouse models (11,12).…”

Section: Introductionmentioning

confidence: 99%

Increased Expression and Activation of Absent in Melanoma 2 Inflammasome Components in Lymphocytic Infiltrates of Abdominal Aortic Aneurysms

Dihlmann

Erhart

Mehrabi

et al. 2014

Mol Med

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Section: Introductionmentioning

confidence: 99%

Increased Expression and Activation of Absent in Melanoma 2 Inflammasome Components in Lymphocytic Infiltrates of Abdominal Aortic Aneurysms

Dihlmann

Erhart

Mehrabi

et al. 2014

Mol Med

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“…* P < 0.05, *** P < 0.001 versus control; @@ P < 0.01, @@@ P < 0.001 low Ox-LDL versus high Ox-LDL; pro-IL-1 ␤ and mature IL-1 ␤ protein expression were signifi cantly attenuated by free radical scavenger NAC and NADPH oxidase INH DPI, it is quite possible that ROS play a role in IL-1 ␤ processing. Earlier studies have also shown that free radicals mediated caspase-1 activation and IL-1 ␤ production in THP1 monocytes and macrophages after Ox-LDL stimulation ( 7,46 ).…”

Section: Discussionmentioning

confidence: 89%

“…For studying the effect of Ox-LDL on cell lines expressing higher amounts of CD36, we used PMA-differentiated THP1 cells, which express high amounts of this receptor ( 46 ) and were also used in studies such as ( 7 ). Gene silencing with TLR2-, TLR4-, TLR6-, or CD36-specifi c siRNA in THP1 monocytes and macrophages signifi cantly attenuated Ox-LDL-induced PKC ␦ and IRAK1 activation and IL-1 ␤ production, suggesting that TLR2, TLR4, TLR6, and CD36 can mediate Ox-LDL-induced effects seen in the present study.…”

Section: Discussionmentioning

confidence: 99%

PKCδ-IRAK1 axis regulates oxidized LDL-induced IL-1β production in monocytes

Tiwari

Singh

et al. 2014

Journal of Lipid Research

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“…Se encontró que CD36 puede reconocer LDL que han sido expuestas a condiciones "mínimamente" oxidantes, y que fueron modificadas, por ejemplo, por el sistema "peróxinitrito-mieloperoxidasa-H2O2" de las células fagociticas (9) . La interacción entre CD36 y LDL-ox también induce la secreción de citoquinas que activan la proliferación y migración de las células hacia la íntima arterial (10) , y la inflamación arterial provocada por las células espumosas puede producir con el tiempo un estrechamiento de la luz arterial (10) .…”

Section: Introductionunclassified

sCD36 sérico y variables cardiometabólicas en dos poblaciones peruanas: Carhuamayo (4100 msnm) y Mala (30 msnm)

et al. 2017

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RESUMENObjetivo: Determinar los niveles séricos de sCD36, molécula relacionada al metabolismo lipídico, en poblaciones de la altura y del nivel del mar, y establecer la asociación de este parámetro con factores de riesgo cardiometabólico. Materiales y métodos: Participaron 45 personas de Carhuamayo (4100 msnm) y 40 personas de Mala (30 msnm). Se midió el peso, talla y presión arterial. Se determinó la hemoglobina en sangre total, y la glucosa, perfil lipídico y sCD36 en suero. Resultados: Se encontró en la población de Carhuamayo niveles de hemoglobina significativamente mayores, mientras que el peso, IMC y nivel de glucosa fueron significativamente menores que en Mala. No hubo diferencia significativa entre los niveles séricos de sCD36 de ambas poblaciones. Se observó una diferencia significativa entre los valores medios de sCD36 según el IMC, y una correlación positiva significativa entre sCD36 y el peso e IMC. Conclusiones: El nivel sérico observado de sCD36 es independiente de la altitud y puede ser considerado como marcador potencial de síndrome metabólico.Palabras clave: sCD36; factor de riesgo cardiometabólico; obesidad; altitud (Fuente: DeCS BIREME). Serum levels of sCD36 and cardiometabolic variables in two Peruvian towns: Carhuamayo (4100 masl) and Mala (30 masl)ABSTRACT Objectives: To determine the serum levels of sCD36, a lipid metabolism-related molecule, in high-altitude and sea-level populations, and to establish the association of this parameter with cardiometabolic risk factors. Materials and methods:The study population consisted of 45 people from Carhuamayo (4100 masl) and 40 people from Mala (30 masl). Weight, height and blood pressure were measured. Hemoglobin was determined in whole blood, and glucose, lipid profile and sCD36 in serum. Results: It has been found that hemoglobin levels in the population of Carhuamayo were significantly higher, while weight, BMI and glucose level were significantly lower than those in the population of Mala. There was no significant difference between serum levels of sCD36 in both populations. A significant difference was observed between sCD36 mean serum levels of both populations based on the BMI, and a significant positive correlation between sCD36 and the weight and BMI. Conclusions: The observed sCD36 serum level is not related to the altitude and can be considered as a potential marker of metabolic syndrome.

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Oxidized low-density lipoprotein induces secretion of interleukin-1β by macrophages via reactive oxygen species-dependent NLRP3 inflammasome activation

Cited by 143 publications

References 24 publications

Increased Expression and Activation of Absent in Melanoma 2 Inflammasome Components in Lymphocytic Infiltrates of Abdominal Aortic Aneurysms

Increased Expression and Activation of Absent in Melanoma 2 Inflammasome Components in Lymphocytic Infiltrates of Abdominal Aortic Aneurysms

PKCδ-IRAK1 axis regulates oxidized LDL-induced IL-1β production in monocytes

sCD36 sérico y variables cardiometabólicas en dos poblaciones peruanas: Carhuamayo (4100 msnm) y Mala (30 msnm)

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