Oxidized low-density lipoprotein, matrix-metalloproteinase-8 and carotid atherosclerosis in spinal cord injured subjects

Paim, Layde R.; Schreiber, Roberto; Matos‐Souza, José R.; Silva, Anselmo A.; Campos, Luis Felipe Castelli Correia de; Azevedo, Eliza Regina Ferreira Braga Machado de; Alonso, Karina Cristina; Rossi, Gianpaolo; Etchebehere, Maurício; Gorla, José Irineu; Cliquet, Alberto; Nadruz, Wilson

doi:10.1016/j.atherosclerosis.2013.10.005

Cited by 22 publications

(26 citation statements)

References 27 publications

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“…19 OxLDL is also known to be associated with physical activity in SCI: 20 subjects with chronic SCI exhibited higher oxLDL levels compared with physically active SCI and able-bodied persons. In the present study, we showed that oxLDL levels were higher in LSCI than in CSCI athletes.…”

Section: Discussionmentioning

confidence: 99%

Changes in oxidized LDL during a half marathon in athletes with spinal cord injuries

Mitsui

Ito

Sasaki

et al. 2017

Spinal Cord Ser Cases

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Introduction:We reported previously that exercise significantly increases plasma adrenaline and oxidized low-density lipoprotein (oxLDL) in healthy subjects but not in persons with spinal cord injury (SCI). Since oxLDL and adrenaline levels are associated with oxidant/antioxidant balance, and exercise training elicits production of reactive oxygen species, we elucidated the effects of exercise on adrenaline, oxidant/antioxidant balance and oxLDL in individuals with SCI.Case Presentation:Eight subjects with cervical spinal cord injury (CSCI) and nine subjects with lower lesion of SCI (lower SCI (LSCI)) participated in a wheelchair half marathon race, and blood samples were collected before (pre), immediately after (post) and 1 h after the race (post 1 h). The blood samples were used to determine adrenaline, derivatives of reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP), both as markers for oxidant/antioxidant balance.Discussion:Pre-serum oxLDL levels were 147.2±8.1 and 97.0±10.4 U l−1 (mean±s.e.m.) in LCSI and CSCI subjects, respectively, and remained stable throughout the study. Adrenaline levels were higher in LSCI athletes than in CSCI athletes, especially post half marathon. Serum d-ROMs level did not change between pre and post in both groups. The mean BAP was significantly higher in LSCI than in CSCI subjects (2574±94.6 vs 2118±94.6 μmol l−1) at post, whereas the oxidative stress index (d-ROMs/BAP) was similar in the two groups throughout the study. In conclusion, exercise did not increase the d-ROMs or d-ROMs/BAP ratio in CSCI and LSCI subjects. The lack of increase in the plasma oxLDL level in SCI subjects was not due to the lack of response of adrenaline to exercise.

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Section: Discussionmentioning

confidence: 99%

Changes in oxidized LDL during a half marathon in athletes with spinal cord injuries

Mitsui

Ito

Sasaki

et al. 2017

Spinal Cord Ser Cases

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“…В динамике при повторном обсле-довании детей основной группы наблюдали снижение уровня плазменной ММП-8 в сравнении с первым этапом исследования до 20,5 ± 5,8 нг/мл, но полученные ре-зультаты достоверно отличались от показателей группы сравнения (р ≤ 0,01). Вероятно, динамика значений уровня матриксной металлопротеиназы-8 у новорожден-ных детей с внутриутробной ГИ сопряжена с ведущей ролью фагоцитов, являющихся одними из основных про-дуцентов ММП-8, на ранних этапах инфекционного про-цесса [4,5,14].…”

Section: результаты и их обсуждениеunclassified

Plasma Markers of Degradation of Extracellular Matrix with Intrauterine Herpes Infection

Бениова¹,

Юрьевич²,

Kornilova³

2016

Det. infekc.

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Дальневосточный федеральный университет, Школа биомедицины 1 , Тихоокеанский государственный медицинский университет 2 , Владивосток, Россия Проведено изучение динамики сывороточных уровней матриксных металлопротеиназ (ММП-8, ММП-9) и их тканевого инги-битора (ТИМП-1) у новорожденных детей с внутриутробной герпетической инфекцией в ранний неонатальный период. Было исследовано 38 детей, рожденных от матерей с хроническим течением герпетической инфекции (ГИ). Высокие концентрации плазменных матричных металлопротеиназ и их тканевого ингибитора у новорожденных с внутриутробной герпетической ин-фекцией свидетельствует об активации процессов разрушения внеклеточного матрикса и предшествуют реализации клиниче-ских проявлений инфекции. Увеличение уровня ММП-9 при сохранении стабильных или снижающихся значений ТИМП-1 от-ражает патогенетическую активность инфекционного процесса, сопровождающегося избыточным протеолизом. The study of the dynamics of serum levels of matrix metalloproteinases (MMP-8, MMP-9) and tissue inhibitor (TIMP-1) in newborns with intrauterine herpes infection in the early neonatal period. It has been studied 38 children born to mothers with chronic herpes infections (НI). High concentrations of plasma matrix metalloproteinase and tissue inhibitor in infants with intrauterine herpes infection indicates the activation of the destruction of the extracellular matrix and is preceded by the implementation of the clinical manifestations of infection. Increased levels of MMP-9, while maintaining stable or decreasing values of TIMP-1 reflects the pathogenic activity of the infectious process, accompanied by excessive proteolysis.

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“…Субстрактами для ММП-8 также могут быть нематричные компоненты: плазминоген, фибрин, фибронектин и др. [15].…”

Section: российский вестник перинатологии и педиатрии 1 2016 Rossiyunclassified

“…Вероятно, динамика уровня ММП-8 у новоро-жденных детей с различными сроками реализации герпетической инфекции на ранних этапах инфекци-онного процесса сопряжена с ведущей ролью фаго-цитов, являющихся одними из основных продуцен-тов ММП-8 [9,15].…”

Section: российский вестник перинатологии и педиатрии 1 2016 Rossiyunclassified

Clinical significance of the determination of matrix metalloproteinases in newborns with congenital herpes virus infection

Бениова¹,

Фиголь²,

Маркелова³

2016

Ross. vestn. perinatol. pediatr.

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Oxidized low-density lipoprotein, matrix-metalloproteinase-8 and carotid atherosclerosis in spinal cord injured subjects

Cited by 22 publications

References 27 publications

Changes in oxidized LDL during a half marathon in athletes with spinal cord injuries

Changes in oxidized LDL during a half marathon in athletes with spinal cord injuries

Plasma Markers of Degradation of Extracellular Matrix with Intrauterine Herpes Infection

Clinical significance of the determination of matrix metalloproteinases in newborns with congenital herpes virus infection

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