Oxidized Soybean Oil Evoked Hepatic Fatty Acid Metabolism Disturbance in Rats and their Offspring

Abstract

The oxidation of fats and oils is an undisputed subject of science, given the effect of oxidized fats and oils on food quality and safety. This study aimed to determine whether maternal exposure to oxidized soybean oil (OSO) causes lipid metabolism disorders in the liver and whether this lipid metabolism disorder can be transmitted to offspring or even worsened. A total of 60 female Sprague–Dawley (SD) rats were divided randomly into four groups in this study. Treatment groups received a pure diet of OSO with a peroxide value of 200, 400, or 800 mEqO2/kg, while the control group received fresh soybean oil (FSO). As for our results, OSO affected serum biochemical parameters in the maternal generation (F0) and induced liver histopathology changes, inflammation, and oxidative stress. Moreover, the expression of genes related to the liver X receptor α (LXRα)sterol regulatory element binding protein-1c (SREBP-1c) signaling pathway was changed. Similar trends were found in the livers of offspring on postnatal days 21 and 56. In conclusion, exposure to OSO during gestation and lactation can affect liver lipid synthesis. Additionally, it is detrimental to the development of the offspring’s liver, affecting fatty acid metabolism and causing liver damage.

Dietary Resveratrol Ameliorates Hepatic Fatty Acid Metabolism and Jejunal Barrier in Offspring Induced by Maternal Oxidized Soybean Oil Challenge

“…52 53,54 In this study, we found that the OSO challenge significantly increased the piglet liver H 2 O 2 content and markedly decreased SOD and CAT activities. This is similar to the findings in our prior research that maternal exposure to OSO resulted in higher H 2 O 2 levels and lower activity of CAT and SOD in the liver of offspring, 30 whereas Res supplementa- tion in the OSO group improved the content of H 2 O 2 and restored the CAT and SOD activities. The finding was also supported by Fu et al, who found that Res enhanced the levels of antioxidants SOD and CAT and protected rats from ROS.…”

“…This is similar to our previous findings that lipid vacuoles were in the cytoplasm of offspring liver cells after the maternal challenge with OSO. 30 In the OSO + Res group, membrane integrity improved and cytoplasmic vacuolization was reduced after Res supplementation.…”

“…We previously did a lot of studies on the damage of maternal exposure to oxidized soybean oil (OSO) to mothers and offspring. Our previous studies have shown that maternal exposure to OSO damages the placental, the offspring’s liver, kidney, and intestine. , Hence, it is especially significant to seek out a way to mitigate the damage of an OSO to both maternal and offspring.…”

Bacillus siamensis Targeted Screening from Highly Colitis-Resistant Pigs Can Alleviate Ulcerative Colitis in Mice

“…Therefore, the pathogenicity of the strains should be tested. According to previous reports [ 44 ], a strain was considered pathogenic if the animals in the test group exhibited signs of toxicity or died during the experiment or if there were significant differences in physiological indicators such as body weight between the test group and control group. Our in vivo trial revealed that oral administration of B. siamensis MZ16 to mice did not result in adverse effects.…”