Óxido nítrico exhalado en niños: un indicador no invasivo de la inflamación de las vías aéreas

Barroso, Nicolás Cobos; Pérez-Yarza, Eduardo González; Prado, Olaia Sardón; Bover, Conrado Reverté; Gartner, Sílvia; Murua, Javier Korta

doi:10.1157/13114655

Cited by 26 publications

(3 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…FeNO was calculated as the mean of 3 correct exhalations. All measurements were performed in parts per billion (ppb) [8,9].…”

Section: Methodsmentioning

confidence: 99%

Eosinophilic Airway Inflammation: The Effectiveness of Nasal Steroids

Peirolo¹

2015

J Otolaryngol Rhinol

View full text Add to dashboard Cite

The prevalence of asthma and rhinitis is on the increase and these conditions are frequently associated, thus leading to the concept that these two conditions are different aspects of the same disease: "one airway, one disease" [2]. Most of patients with allergic (80%) and non-allergic asthma (75%) have concomitant rhinitis, while, approximately 34% of patients with allergic rhinitis and 25% of patients with non-allergic have concomitant asthma [2,3]. Although upper and lower airway diseases commonly occur together, clinicians have yet to determine the exact nature of the association between these two chronic conditions and to test the hypothesis that treating rhinitis reduces health care utilization for co-morbid asthma [4].In the present study, we used FeNO and nasal cytology to investigate upper and lower airway inflammation and the clinical benefits of nasal treatment in children with asthma. Methods and Study Population Study populationA total of 84 patients, 4-17 years of age, 53 males and 31 females, coming from the allergology outpatient "Filippo del Ponte", were clinically examined from 1 November 2013 to 31 July 2014. All participants were interviewed about respiratory symptoms thanks to ACT (Asthma Control Test) or C-ACT (Childhood-Asthma Control Test) and SNOT (Sino-Nasal Outcome Test); lung function and airway inflammation were measured using HyPAIR FeNO and nasal cytology in children free of treatment (systemic antihistamine and/or nasal steroids) for at least 10 days' time.Furthermore the allergic sensitization to common aeroallergens (birch, core, olive tree, grasses, ragweed, parietaria, dog, cat, house dust mite: DPP and DPF 1 , mould: alternaria) and foods (cow lactalbumin, cow casein, egg white and yolk, peanuts) was evaluated by skin prick-test and used to classify patients in two groups: allergic (72, 47 males and 25 females) and non-allergic (12, 6 males and 6 females). Histamine hydrochloride, 10 mg/mL, and phenolated glycerol-saline served as positive and negative controls. The reaction was regarded as positive if the mean wheal diameter was at least 3 mm greater than negative control [5].

show abstract

“…FeNO was calculated as the mean of 3 correct exhalations. All measurements were performed in parts per billion (ppb) [8,9].…”

Section: Methodsmentioning

confidence: 99%

Eosinophilic Airway Inflammation: The Effectiveness of Nasal Steroids

Peirolo¹

2015

J Otolaryngol Rhinol

View full text Add to dashboard Cite

show abstract

“…The measurement of FE NO also allows assessing the degree of bronchial inflammation in the child. 160 The evaluation of FE NO in young children is not relevant for predicting a diagnosis of asthma at school age. 161 The diagnostic reliability of FE NO in asthma is compromised by the wide confidence intervals of this measurement and the overlapping of FE NO values between children without asthma and atopic dermatitis.…”

Section: Diagnosismentioning

confidence: 99%

GEMA 5.3. Spanish Guideline on the Management of Asthma

Plaza Moral,

Alobid,

Álvarez Rodríguez

et al. 2023

Open Respiratory Archives

Self Cite

View full text Add to dashboard Cite

“…La fracción exhalada de óxido nítrico (FE NO ) se considera un buen marcador reproducible y no invasivo de inflamación eosinófila de la vía respiratoria, que resulta de utilidad en el diagnóstico de asma, en el control de la enfermedad y en la monitorización del tratamiento en niños 1,2 . El NO es un radical libre endógeno simple y difusible, que actúa en el sistema respiratorio como broncodilatador débil, vasodilatador potente y neurotransmisor del sistema no colinérgico y no adrenérgico.…”

Section: Introductionunclassified