Oximes of five-membered heterocyclic compounds with two heteroatoms 2. Reactions and biological activity (Review)

Abstract

Data on the reactions of oxazole, thiazole, pyrazole, and imidazole aldoximes, ketoximes, amidoximes, and their derivatives are reviewed. The synthesis of new heterocycles based on the oximes of fivemembered heterocyclic compounds with two heteroatoms are considered separately. The principal results from investigation of the biological activity of the ethers of these oximes are also presented.

Unusual Synthesis and Cytotoxicity of N-[2-(Benzothiazol-2-Sulfonyl)-1-Ethoxyethoxy]- 5-(Benzothiazol-2-Ylsulfanyl)Pentanamidine

“…1 H NMR spectrum (200 MHz, : 6.71 and 6.97 (both d, 1H, J = 13 Hz, CH=CH); 7.33 and 7.45 (both t, 2H, J = 8 Hz, 5-H and 6-H); 7.78 and 7.92 (both d, 2H, J = 8 Hz, 4-H and 7-H). Mass spectrum, m/z (relative intensity): 227 (M + , 2), 192 (100), 148 (10), 108 (10), 96 (10), 69 (9). (4).…”

“…Substituted imidazo [2,1-b]thiazoles exhibit high antitumor and cytotoxic activities [9]. It is necessary to mention that many publications are devoted to thiazole oximes, which feature in the composition of cephalosporin antibiotics [10]. Beside this, thiazole oximes [11] or their platinum complexes are tested as cytotoxic and antitumor agents [12].…”