Oxotremorine‐induced hypertension in the anaesthetized rat

Walker, Joyce L.; Weetman, D.F.

doi:10.1111/j.1476-5381.1970.tb10357.x

Cited by 10 publications

(2 citation statements)

References 12 publications

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“…The lack of a hypotensive effect with oxotremorine in methylatropine pretreated rats is consistent with the observations of Brezenoff & Jenden (1969) and Brezenoff & Wirecki (1970) that the transient hypotension following micro-injections of oxotremorine into the posterior hypothalamus of rats was prevented by systemically administered methylatropine. Likewise, the rise in blood pressure observed in anaesthetized rats is consistent with the observations of Walker & Weetman (1970). The lack of effect of oxotremorine on blood pressure in normotensive rats or spontaneously hypertensive rats that were conscious suggests an influence of anaesthesia on the oxotremorine response.…”

Section: Discussionsupporting

confidence: 85%

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A Centrally Mediated Prolonged Hypotension Produced by Oxotremorine or Pilocarpine

Dage¹

1979

British J Pharmacology

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1 Oxotremorine, methyloxotremorine, pilocarpine or arecoline were given intravenously to anaesthetized cats, dogs or rats, and intraperitoneally to conscious normotensive and spontaneously hypertensive rats, pretreated with doses of methylatropine that completely blocked peripheral muscarinic receptors, to ascertain their effects on blood pressure and heart rate. 2 Oxotremorine but not methyloxotremorine produced a prolonged hypotension in cats and dogs but not in rats. Heart rate was not changed. Pilocarpine, although less potent, produced an identical effect, whereas the effect of arecoline was short by comparison. The hypotensive effect of these drugs was reversed by atropine. 3 In dogs, oxotremorine produced a prolonged hypotension with no change in heart rate or cardiac output.4 A decrease in spontaneous sympathetic nerve activity accompanied the hypotension in cats. Both effects were reversed by atropine but could be reinvoked by large doses of oxotremorine. 5 The oxotremorine-induced hypotension in cats was not altered by decerebration but was abolished by high cervical spinal section. 6 The results indicate that the prolonged hypotension elicited by oxotremorine is mediated by an action at muscarinic receptors in the brain stem resulting in a decrease in sympathetic nerve activity and peripheral resistance but not heart rate or cardiac output.

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Section: Discussionsupporting

confidence: 85%

“…Likewise, the rise in blood pressure observed in anaesthetized rats is consistent with the observations of Walker & Weetman (1970). The lack of effect of oxotremorine on blood pressure in normotensive rats or spontaneously hypertensive rats that were conscious suggests an influence of anaesthesia on the oxotremorine response.…”

Section: Spinal Catssupporting

confidence: 79%

A Centrally Mediated Prolonged Hypotension Produced by Oxotremorine or Pilocarpine

Dage¹

1979

British J Pharmacology

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The role of brain acetylcholine in cardiovascular regulation and hypertension: A minireview and therapeutic implications

Brezenoff¹,

Coram²

1982

Drug Development Research

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Brezenoff, H.E., and W.M. Coram: The role of brain acetylcholine in cardiovascular regulation and hypertension: A minireview and therapeutic implications. Drug Dev. Res. 2251Res. -258. 1982 Acetylcholine in the central nervous system exerts a significant influence on cardiovascular parametzrs and appears to be involved in some aspects of hypertension. Stimulation of central muscarinic receptors with direct-acting cholinomimetics or with acetylcholinesterase inhibitors evokes a rise in blood pressure in unanesthetized cats, dogs, rats, and humans. Anesthetics may significantly modify this response. Concomitant with the pressor response is a potentiation of reflex bradycardia, inhibition of reflex tachycardia, and enhancement of the pressor reflex to carotid artery occlusion. Administration of atropine or intracerebroventricular injection of hemicholiniurn-3 reduces blood pressure in spontaneously hypertensive rats (SHR) but not in normotensive rats. Preliminary results are presented showing that systemic or central injection of N-(4-diethyl-2-butynyl)-succinimide, a muscarinic receptor antagonist specific for central receptors, also reduces blood pressure in SHR but not in normotensive animals.

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Memory facilitation with posttrial injection of oxotremorine and physostigmine in mice

et al. 1979

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The immediate posttrial injection of oxotremorine (0.125, 0.250 and 0.500 muMol/kg i.p.) and equimolecular doses of physostigmine can facilitate the retention of a passive avoidance response in mice. Injections given 10 min after training also significantly facilitate retention, but injections given 30 or 120 min after training do not affect retention. These findings suggest an action of oxotremorine and physostigmine on mechanisms involved in memory storage. The enhanced retention produced by oxotremorine and physostigmine was blocked by pretreatment with atropine (2 muMol/kg, 20 min, i.p.) but was not affected by methylatropine (2 muMol/kg, 20 min, i.p.). The retention was not modified by posttrial injection of metoxotremorine (0.25 muMol/kg i.p.) or neostigmine (0.250 muMol/kg i.p.), quaternary analogs of oxotremorine and physostigmine, respectively. The results suggest a central action of both cholinergic agents attributable to an activation of muscarinic brain receptors.

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Oxotremorine‐induced hypertension in the anaesthetized rat

Cited by 10 publications

References 12 publications

A Centrally Mediated Prolonged Hypotension Produced by Oxotremorine or Pilocarpine

A Centrally Mediated Prolonged Hypotension Produced by Oxotremorine or Pilocarpine

The role of brain acetylcholine in cardiovascular regulation and hypertension: A minireview and therapeutic implications

Memory facilitation with posttrial injection of oxotremorine and physostigmine in mice

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