2024
DOI: 10.1101/2024.08.03.606365
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Oxphos Targeting of Mycn-Amplified Neuroblastoma

Soraya Epp,
Donagh Egan,
Evon Poon
et al.

Abstract: Abstract/SummaryHigh risk - neuroblastoma (HR-NB) is a pediatric solid tumor with high lethality. Half of HR-NB are driven by MYCN gene amplification (MNA). These HR-NBs require high dosage chemotherapy and often relapse. Moreover, current therapies can cause severe long-term side effects and new therapies are urgently needed. This study investigates a novel therapeutic approach targeting the metabolic vulnerabilities of MNA NB cells. We discovered that Diphenyleneiodonium chloride (DPI), an inhibitor of flavo… Show more

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