Oxprenolol and retroperitoneal fibrosis.

Abstract

1459suggest that ibuprofen has minor effects on the cardiovascular system, but our experience points to the contrary.Care should be exercised in prescribing ibuprofen to people who are liable to take overdoses.

Retroperitoneal fibrosis and β‐blocking agents: Is there an association?

“…After excluding duplicates and screening for eligibility of 424 initial hits in our electronic search, 31 full‐text articles were retrieved for scrutiny (Figure 2). This resulted in 18 case reports for inclusion in this study 10–27 . No additional cases were identified in the manual searches through references.…”

“…Patients were typically treated with a BBA for hypertension and/or ischaemic cardiac disease. In 6 cases (33%), other antihypertensive agents were used concurrently, 12–14,16,21,25 in 8 cases (44%) comedication was not reported 15,17–20,22,23,27 . In 10 cases (56%), with available information on comedication, concomitant use of methysergide or other ergot alkaloids was not reported 10–14,16,21,24–26 .…”

“…Histogram showing published case reports over time 10–27 . There was predominant reporting of the possible association of retroperitoneal fibrosis with β‐blocking agents in the last 2 decades of the 20 th century…”

Toxic Nephropathies

“…Rarely, the fibrosis encircles the vasculature. Table 16 lists toxins that can cause retroperitoneal fibrosis (249)(250)(251). Druginduced retroperitoneal fibrosis has been most clearly recognized with prolonged ingestion of methysergide (250).…”

Drug-induced retroperitoneal fibrosis: short aetiopathogenetic note, from the past times of ergot-derivatives large use to currently applied bio-pharmacology

“…In comparison with many reports on the RPF occurrence following the long term use of either nonselective (propranolol, oxprenolol, sotalol, labetalol) or β 1 -selective adrenergic blockers (atenolol, metoprolol) (33)(34)(35)(36), subsequent findings of a thorough study (37) led to suggest that such drugs do not cause RPF.…”