Oxybutynin in primary hyperhidrosis: A long‐term real‐life study

Almeida, António Bernardino de; Ferrari, Fernanda; Restrepo, Maria Victoria Suárez; Rocha, Vanessa Barreto

doi:10.1111/dth.14344

Cited by 5 publications

(5 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, QoL improved in 77% of patients after treatment with oral oxybutynin [ 39 ]. Accordingly, oxybutynin has also shown efficacy in patients with baseline impaired QoL [ 40 , 41 ]. Thirty eight to 63 percent of patients with primary palmar HH [ 42 – 44 ] and 89.8% of patients with plantar HH have very poor QoL prior to treatment with sympathectomy [ 19 ].…”

Section: Resultsmentioning

confidence: 99%

“… Wolosker et al 2014 [ 40 ] HQLQ Pre-post interventional study 565 65.5% of patients with very poor pre-treatment QoL and 75% patients with poor pre-treatment QoL had improved QoL after oral oxybutynin. Almeida et al, 2020 [ 41 ] HDSS Pre-post interventional study 30 Patients with primary HH with HDSS scores of 3 or 4 have a significant improvement in their HDSS scores after oxybutynin treatment. Wang et al 2011 [ 42 ] HQLQ Pre-post interventional study 120 63.3% of patients with palmar HH have very poor QoL pre-sympathectomy.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

The Impact of Hyperhidrosis on Quality of Life: A Review of the Literature

2023

View full text Add to dashboard Cite

Hyperhidrosis is a condition of excessive sweating, which can have profound physical and mental effects. Hyperhidrosis is a significantly impactful and distressing illness that warrants equal attention as other more well-known dermatologic conditions. However, because of a lack of awareness among the public, stigma, and difficulty with access to treatments (due to cost or insurance coverage), patients are less likely to be diagnosed and treated. In hyperhidrosis, quality-of-life surveys can be useful for determining the magnitude of symptoms and to evaluate treatment outcomes. The purpose of this study was to conduct a narrative literature review to investigate the impact of hyperhidrosis on quality of life. A total of 49 articles investigating the impact of primary hyperhidrosis on quality of life were selected for the review. Hyperhidrosis is a potentially debilitating illness that affects multiple domains of patients’ lives including their psychological, physical, and social functioning. Despite the significant impacts, patients with hyperhidrosis are less likely to seek care. Here, we explore these impacts, and disparities in care, in more detail.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

The Impact of Hyperhidrosis on Quality of Life: A Review of the Literature

2023

View full text Add to dashboard Cite

show abstract

“…The treatment for PPH comprises surgical and conservative traditional clinical therapies. Conservative clinical therapies contain skin application of antiperspirant agents, anticholinergic drugs, iontophoresis, Botulinum injections, photodynamic therapy and others (3)(4)(5)(6)(7). Regardless, all of these therapies have a temporary duration of effect, and some drugs may generate serious side effects if used for an extended period of time.…”

Section: Introductionmentioning

confidence: 99%

Impact of endoscopic thoracic R4 sympathicotomy combined with R3 ramicotomy for primary palmar hyperhidrosis

Huang

Liu²,

Zou³

et al. 2023

Front. Surg.

View full text Add to dashboard Cite

BackgroundEndoscopic thoracoscopic sympathectomy (ETS) is the preferred method for treating primary palmar hyperhidrosis (PPH) that bears the risk of compensatory hyperhidrosis (CH) following surgery. The current study aims to evaluate the effectiveness and safety of an innovative surgical procedure of ETS.MethodsA survey of the clinical data of 109 patients with PPH who underwent ETS in our department from May 2018 to August 2021 was retrospectively conducted. The patients were organized into two groups. Group A underwent R4 sympathicotomy combined with R3 ramicotomy. Group B underwent R3 sympathicotomy. Patients were followed up to evaluate the safety, effectiveness and the incidence of postoperative CH of the modified surgical approach.ResultsA total of 102 patients completed follow-up, and seven of the total enrolled patients were lost to follow-up, with a loss rate of 6% (7/109). Among these, Group A constitutes 54 cases, group B constitutes 48 cases, and the mean follow-up was 14 months (interquartile range 12–23 months). There was no statistically difference in surgical safety, postoperative efficacy, and postoperative quality of life (QoL) score between group A and group B (p > 0.05). The score of the psychological assessment was higher (p = 0.004) in group A (14.15 ± 2.06) compared to group B (13.30 ± 1.86). The incidence of CH in group A was lower than in group B (p = 0.019).ConclusionR4 sympathicotomy combined with R3 ramicotomy is safe and effective for PPH treatment, along with a reduced incidence of postoperative CH rate and improved postoperative psychological satisfaction.

show abstract

“…Oral administration of Oxybutynin is prone to produce adverse reactions such as dry mouth due to the presence of cholinergic receptors in oral salivary glands and the greater efficacy of N-deethyloxybutynin in producing dry mouth than Oxybutynin. [10] Additionally, oxybutynin was considered an effective and safe drug for the treatment of hyperhidrosis. [10] Oxybutynin has displayed a beneficial effect on nerve activity and neurogenic bladder dysfunction in in vivo experiments.…”

mentioning

confidence: 99%

“…[10] Additionally, oxybutynin was considered an effective and safe drug for the treatment of hyperhidrosis. [10] Oxybutynin has displayed a beneficial effect on nerve activity and neurogenic bladder dysfunction in in vivo experiments. [11,12] Oxybutynin is evidenced with protective effects on bladder ultrastructure in rabbits and rats with detrusor overactivity.…”

mentioning

confidence: 99%

Oxybutynin ameliorates LPS‐induced inflammatory response in human bladder epithelial cells

Chen,

Li,

Wang

et al. 2023

J Biochem & Molecular Tox

View full text Add to dashboard Cite

Urinary tract infection (UTI) mainly results from bacterial infections in the urinary tract and markedly impacts the normal lives of millions of patients worldwide. The infection and damage to urethral epithelial cells is the first and key step of UTI development and is a critical target for treating clinical UTI. Oxybutynin, an agent for treating urinary incontinence, is recently claimed with protective effects on bladder ultrastructure. Our study will assess the impact of Oxybutynin on inflammation in lipopolysaccharide (LPS)‐stimulated bladder epithelial cells. Bladder epithelial T24 cells were treated with 1 μg/mL LPS with or without 10 and 20 μM Oxybutynin for 24 h. Increased levels of oxidative stress (OS) biomarkers, such as reactive oxygen species, 8‐hydroxy‐2'‐deoxyguanosine, malondialdehyde, as well as upregulated inducible nitric oxide synthase and promoted release of nitric oxide, were observed in LPS‐managed T24 cells, all of which were signally suppressed by Oxybutynin. Furthermore, severe inflammatory responses, including enhanced release of cytokines, upregulated matrix metallopeptidase‐2 (MMP‐2) and MMP‐9, and raised monocyte chemoattractant protein‐1 level, were found in LPS‐challenged T24 cells, which were markedly reversed by Oxybutynin. Moreover, the activated toll‐1ike receptor 4/nuclear factor‐κB pathway observed in LPS‐managed T24 cells was repressed by Oxybutynin. Collectively, Oxybutynin mitigated LPS‐induced inflammatory response in human bladder epithelial cells.

show abstract

Oxybutynin in primary hyperhidrosis: A long‐term real‐life study

Cited by 5 publications

References 8 publications

The Impact of Hyperhidrosis on Quality of Life: A Review of the Literature

The Impact of Hyperhidrosis on Quality of Life: A Review of the Literature

Impact of endoscopic thoracic R4 sympathicotomy combined with R3 ramicotomy for primary palmar hyperhidrosis

Oxybutynin ameliorates LPS‐induced inflammatory response in human bladder epithelial cells

Contact Info

Product

Resources

About