Oxygen administration for the resuscitation of term and preterm infants

Trevisanuto, Daniele; Gizzi, Camilla; Martano, C; Cengio, Valentina Dal; Ciralli, Fabrizio; Torielli, Flaminia; Villani, Paolo; Fabio, Sandra Di; Quartulli, Lorenzo; Giannini, Luigi

doi:10.3109/14767058.2012.712344

Cited by 4 publications

(2 citation statements)

References 48 publications

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“…11 Avoiding invasive ventilation appears to be the primary method that may possibly reduce the incidence of BPD, 12 yet this approach is overly simplistic since the oxygen requirement of the infant is ultimately constrained. 13 Therefore, further work is required to discover other management strategies.…”

Section: Introductionmentioning

confidence: 99%

Metyrapone Alleviates Deleterious Effects of Maternal Food Restriction on Lung Development and Growth of Rat Offspring

et al. 2015

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Maternal food restriction (MFR) causes intrauterine growth restriction, a known risk factor for developing chronic lung disease. However, it is unknown whether this negative outcome is gender specific or preventable by blocking the MFR-induced hyperglucocorticoidism. Using a well-established rat model, we used metyrapone (MTP), an inhibitor of glucocorticoid synthesis, to study the MFR-induced lung changes on postnatal day (p) 21 in a gender-specific manner. From embryonic day 10 until delivery, pregnant dams were fed either an ad libitum diet or a 50% caloric restricted diet with or without MTP supplementation. Postnatally, the offspring were fed ad libitum from healthy dams until p21. Morphometric, Western blot, and immunohistochemical analysis of the lungs demonstrated that MTP mitigated the MFR-mediated decrease in alveolar count, decrease in adipogenic protein peroxisome proliferator-activated receptor g, increase in myogenic proteins (fibronectin, a-smooth muscle actin, and calponin), increase in Wnt signaling intermediates (lymphoid enhancer-binding factor 1 and b-catenin), and increase in glucocorticoid receptor (GR) levels. The MFR-induced lung phenotype and the effects of MTP were similar in both genders. To elucidate the mechanism of MFR-induced shift of the adipogenic-to-myogenic phenotype, lung fibroblasts were used to independently study the effects of (1) nutrient restriction and (2) excess steroid exposure. Nutrient deprivation increased myogenic proteins, Wnt signaling intermediates, and GR, all changes blocked by protein supplementation. MTP also blocked, likely by normalizing nicotinamide adenine dinucleotide phosphate levels, the corticosterone-induced increase in myogenic proteins, but had no effect on GR levels. In summary, protein restriction and increased glucocorticoid levels appear to be the key players in MFR-induced lung disease, affecting both genders.

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Section: Introductionmentioning

confidence: 99%

Metyrapone Alleviates Deleterious Effects of Maternal Food Restriction on Lung Development and Growth of Rat Offspring

et al. 2015

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“…An increasing body of evidence suggests that delivery room management of extremely low birthweight (ELBW) infants may have a direct influence on their survival and long‐term morbidity . Therefore, their general outcome could be improved throughout a structured and well‐coded approach starting from the first minutes of life .…”

Section: Introductionmentioning

confidence: 99%