Oxygen- and bubble-generating polymersomes for tumor-targeted and enhanced photothermal–photodynamic combination therapy

Li, Zhouru; Fan, Fan; Ma, Jingyuan; Yin, Wenjiang; Zhu, Dunwan; Zhang, Linhua; Wang, Zhenyuan

doi:10.1039/d1bm00659b

Cited by 14 publications

(8 citation statements)

References 48 publications

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“…The encapsulation of PSs into specifically designed nanosized polymersomes with stimulus-triggered release of PSs has been reported in recent years, including temperature, pH, and light-induced release of the PSs [296,372,373]. For instance, Lanzilotto et al recently reported a system used for aPDT consisting of polymersomes of the tri-blockcopolymer poly(2-methyl-2-oxazoline)-block-poly-(dimethylsiloxane)-block-poly(2-methyl-2-oxazoline) (PMOXA34-PDMS6-PMOXA34) encapsulating water-soluble porphyrin derivatives [372].…”

Section: Polymersomesmentioning

confidence: 99%

Antimicrobial Photodynamic Therapy: Latest Developments with a Focus on Combinatory Strategies

et al. 2021

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Antimicrobial photodynamic therapy (aPDT) has become a fundamental tool in modern therapeutics, notably due to the expanding versatility of photosensitizers (PSs) and the numerous possibilities to combine aPDT with other antimicrobial treatments to combat localized infections. After revisiting the basic principles of aPDT, this review first highlights the current state of the art of curative or preventive aPDT applications with relevant clinical trials. In addition, the most recent developments in photochemistry and photophysics as well as advanced carrier systems in the context of aPDT are provided, with a focus on the latest generations of efficient and versatile PSs and the progress towards hybrid-multicomponent systems. In particular, deeper insight into combinatory aPDT approaches is afforded, involving non-radiative or other light-based modalities. Selected aPDT perspectives are outlined, pointing out new strategies to target and treat microorganisms. Finally, the review works out the evolution of the conceptually simple PDT methodology towards a much more sophisticated, integrated, and innovative technology as an important element of potent antimicrobial strategies.

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Section: Polymersomesmentioning

confidence: 99%

Antimicrobial Photodynamic Therapy: Latest Developments with a Focus on Combinatory Strategies

et al. 2021

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“…PDT is highly dependent on the availability of oxygen (34,35). Therefore, oxygen distribution in cells and tissues should be fully considered in the design of the light source and the choice of photosensitizer.…”

Section: Discussionmentioning

confidence: 99%

Photodynamic therapy with light-emitting diode arrays producing different light fields induces apoptosis and necrosis in gastrointestinal cancer

et al. 2022

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IntroductionLight-emitting diodes (LEDs) have become a new light source for photodynamic therapy (PDT) because of their excellent optical properties, small size, and low cost. LED arrays have so far been designed to meet the need for accurate illumination of irregular lesions. However, LED arrays determine not only the shape of the illuminated spot but also the light field, which has a significant impact on the efficacy of PDT.MethodsWe designed three types of LED arrays producing different light fields, namely an intensive LED array for a uniform light field, a sparse LED array for a non-uniform light field, and a point LED array for a Gaussian-like light field, and investigated the effect and mechanism of these light fields on PDT for gastrointestinal cancer both in vitro and in vivo.ResultsWe found that intensive LED-PDT induced earlier and more serious cell death, including apoptosis and necrosis, than sparse LED-PDT and point LED-PDT. Among the three LED arrays, the intensive LED array induced cells to produce more differential proteins (DEPs), mainly related to mitochondria, ribosomes, and nucleic acids. DEPs in cells subjected to sparse LED- and point LED-PDT were mainly involved in extracellular activities. For MGC-803 tumor-bearing mice, intensive LED-PDT and point LED-PDT had better tumor ablation effect than sparse LED-PDT. Notably, recurrence was observed on day 7 after sparse LED-PDT. VCAM-1 and ICAM-1 were highly expressed in sparse LEDs-PDT treated tumor tissues and were associated tumor angiogenesis, which in turn lead to poor tumor suppression.ConclusionsTherefore, the type of LED array significantly affected the performance of PDT for gastrointestinal cancer. Uniform light field with low power densities work better than non-uniform and Gaussian-like light fields.

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“…Nanoplatforms that catalyze the endogenous H 2 O 2 for in situ O 2 production have thus been extensively studied and applied. Li et al (2021b) prepared oxygen- and bubble-generating polymersomes nanomaterials (FIMPs), which used MnO 2 and indocyanine green, the hydrophobic photosensitizer, as the shell and NH 4 HCO 3 solution as the core, based on the reduction-responsive copolymer (poly (ε-caprolactone)-ss-poly (ethylene glycol)-ss-poly (ε-caprolactone) and 1,2-distearoyl- sn -glycero-3-phosphoethanolamine-N-[folate (polyethylene glycol)-2000]), to combine PTT and PDT in tumor treatments ( Figure 6 ). In vitro and in vivo experiments have shown that FIMPs can facilitate a high accumulation of drugs at the tumor site through EPR and folic acid-mediated targeting effects.…”

Section: Application Of Redox Nanomaterials In Disease Therapymentioning

confidence: 99%

“… Schematic illustration for the formulation and enhanced photothermal–photodynamic combination therapeutic mechanism of oxygen- and bubble-generating polymersomes (FIMPs). Reproduced with permission from ( Li et al, 2021b ) Copyright (2021) Royal Society of Chemistry. …”

Section: Application Of Redox Nanomaterials In Disease Therapymentioning

confidence: 99%

The progress of research on the application of redox nanomaterials in disease therapy

et al. 2023

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Redox imbalance can trigger cell dysfunction and damage and plays a vital role in the origin and progression of many diseases. Maintaining the balance between oxidants and antioxidants in vivo is a complicated and arduous task, leading to ongoing research into the construction of redox nanomaterials. Nanodrug platforms with redox characteristics can not only reduce the adverse effects of oxidative stress on tissues by removing excess oxidants from the body but also have multienzyme-like activity, which can play a cytotoxic role in tumor tissues through the catalytic oxidation of their substrates to produce harmful reactive oxygen species such as hydroxyl radicals. In this review, various redox nanomaterials currently used in disease therapy are discussed, emphasizing the treatment methods and their applications in tumors and other human tissues. Finally, the limitations of the current clinical application of redox nanomaterials are considered.

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Oxygen- and bubble-generating polymersomes for tumor-targeted and enhanced photothermal–photodynamic combination therapy

Abstract: As a common feature of the tumor microenvironment (TME), hypoxia significantly impede the effects of photodynamic therapy. Moreover, for tumor combination therapy, smart responsive and well-designed nanocarriers are highlighted to...

Cited by 14 publications

References 48 publications

Antimicrobial Photodynamic Therapy: Latest Developments with a Focus on Combinatory Strategies

Antimicrobial Photodynamic Therapy: Latest Developments with a Focus on Combinatory Strategies

Photodynamic therapy with light-emitting diode arrays producing different light fields induces apoptosis and necrosis in gastrointestinal cancer

The progress of research on the application of redox nanomaterials in disease therapy

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