Oxygen and Perinatal Origins of Adulthood Diseases

Davidge, Sandra T.; Morton, Jude S.; Rueda-Clausen, Christian F.

doi:10.1161/hypertensionaha.108.120477

Cited by 12 publications

(5 citation statements)

References 10 publications

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“…Oxidative injury has been proposed as a unifying process underlying the perinatal origins of adult disease (8,10). Generation of ROS is also well recognized in the pathogenesis of chronic kidney disease (48,61).…”

Section: Discussionmentioning

confidence: 99%

Accelerated senescence in kidneys of low-birth-weight rats after catch-up growth

Luyckx

Compston

Simmen

et al. 2009

American Journal of Physiology-Renal Physiology

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Epidemiological studies show a strong association between low birth weight and hypertension, renal, and cardiovascular disease, especially after catch-up growth. Senescence is an important contributor to the progression of chronic disease. Developmentally programmed premature senescence may be a link among low birth weight, catch-up growth, and adult disease. Low birth weight was induced by feeding pregnant rats a low-protein diet from day 12 of gestation to 10 days postdelivery. Low- and normal-birth-weight male offspring were weaned onto regular or high-calorie diets to enhance catch-up growth. Kidneys and hearts of offspring were analyzed for RNA and protein markers of stress-induced senescence (p16, p21, p53, Rb). Markers of mitochondrial stress (p66Shc) and activation of endoplasmic reticulum protein secretion (Ero1alpha) were analyzed as regulators of reactive oxygen species generation. Reactive oxygen species are known to be associated with premature aging. Senescence markers were not different in low- or normal-birth-weight kidneys at birth. During rapid catch-up growth, p16 and p21 increased significantly in low-birth-weight kidneys and hearts (P < 0.01). Renal p16 levels increased progressively and were significantly higher in low-birth-weight kidneys at 3 and 6 mo (P < or = 0.02). Renal p66Shc and Ero1alpha were significantly higher in low- compared with normal- birth-weight kidneys at 6 mo, suggesting reactive oxygen species generation (P < or = 0.03). Low-birth-weight rats exhibit accelerated senescence in kidneys and hearts after rapid catch-up growth, a likely important link between early growth and subsequent hypertension, renal, and cardiovascular disease.

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Section: Discussionmentioning

confidence: 99%

Accelerated senescence in kidneys of low-birth-weight rats after catch-up growth

Luyckx

Compston

Simmen

et al. 2009

American Journal of Physiology-Renal Physiology

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“…Oxidative stress during critical growth and development period has been proposed to contribute to the perinatal origins of high blood pressure [11]. In this regard, renal oxidative stress has been suggested to play a pathogenetic role in prenatally programmed hypertension in the rat [47].…”

Section: Introductionmentioning

confidence: 99%

Effects of antenatal, postpartum and post-weaning melatonin supplementation on blood pressure and renal antioxidant enzyme activities in spontaneously hypertensive rats

et al. 2011

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Although melatonin lowers blood pressure in spontaneously hypertensive rats (SHR), its effect following antenatal and postpartum supplementation on the subsequent development of hypertension in SHR pups remains unknown. To investigate this, SHR dams were given melatonin in drinking water (10 mg/kg body weight/day) from day 1 of pregnancy until day 21 postpartum. After weaning, a group of male pups continued to receive melatonin till the age of 16 weeks (Mel-SHR), while no further melatonin was given to another group of male pups (Maternal-Mel-SHR). Controls received plain drinking water. Systolic blood pressure (SBP) was measured at 4, 6, 8, 12 and 16 weeks of age, after which the kidneys were collected for analysis of antioxidant enzyme profiles. SBP was significantly lower till the age of 8 weeks in Maternal-Mel-SHR and Mel-SHR than that in the controls, after which no significant difference was evident in SBP between the controls and Maternal-Mel-SHR. SBP in Mel-SHR was lower than that in controls and Maternal-Mel-SHR at 12 and 16 weeks of age. Renal glutathione peroxidase (GPx) and glutathione s-transferase (GST) activities, levels of total glutathione and relative GPx-1 protein were significantly higher in Mel-SHR. GPx protein was however significantly higher in Mel-SHR. No significant differences were evident between the three groups in the activities of superoxide dismutase, catalase and glutathione reductase. In conclusion, it appears that while antenatal and postpartum melatonin supplementation decreases the rate of rise in blood pressure in SHR offspring, it however does not alter the tendency of offspring of SHR to develop hypertension.

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“…Also, although a role of the above reported pregnancy-related complications in the alteration of the balance between oxidants and antioxidants is conceivable [42,43], the statistical analysis showed that there were no significant differences regarding the parameters of redox balance and oxidative stress between AMA patients with complications and without complications. In fact, 28 patients presented no complications and 36 developed some gestational comorbidities.…”

Section: Discussionmentioning

confidence: 84%

“…The data we obtained about the redox balance in AMA pregnant women up to 48 h after delivery and in umbilical blood could have clinical implications in those subjects and newborns. In this regard, there are data demonstrating that both children born from complicated pregnancies and AMA pregnant women are at increased risk of cardiovascular disease, which could be related to oxidative stress and endothelial dysfunction that had arisen during pregnancy [42][43][44][45][46][47].…”

Section: Discussionmentioning

confidence: 99%

Plasma Redox Balance in Advanced-Maternal-Age Pregnant Women and Effects of Plasma on Umbilical Cord Mesenchymal Stem Cells

Grossini,

Aquino,

Venkatesan

et al. 2024

IJMS

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Pregnancy at advanced maternal age (AMA) is a condition of potential risk for the development of maternal–fetal complications with possible repercussions even in the long term. Here, we analyzed the changes in plasma redox balance and the effects of plasma on human umbilical cord mesenchymal cells (hUMSCs) in AMA pregnant women (patients) at various timings of pregnancy. One hundred patients and twenty pregnant women younger than 40 years (controls) were recruited and evaluated at various timings during pregnancy until after delivery. Plasma samples were used to measure the thiobarbituric acid reactive substances (TBARS), glutathione and nitric oxide (NO). In addition, plasma was used to stimulate the hUMSCs, which were tested for cell viability, reactive oxygen species (ROS) and NO release. The obtained results showed that, throughout pregnancy until after delivery in patients, the levels of plasma glutathione and NO were lower than those of controls, while those of TBARS were higher. Moreover, plasma of patients reduced cell viability and NO release, and increased ROS release in hUMSCs. Our results highlighted alterations in the redox balance and the presence of potentially harmful circulating factors in plasma of patients. They could have clinical relevance for the prevention of complications related to AMA pregnancy.

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Oxygen and Perinatal Origins of Adulthood Diseases

Cited by 12 publications

References 10 publications

Accelerated senescence in kidneys of low-birth-weight rats after catch-up growth

Accelerated senescence in kidneys of low-birth-weight rats after catch-up growth

Effects of antenatal, postpartum and post-weaning melatonin supplementation on blood pressure and renal antioxidant enzyme activities in spontaneously hypertensive rats

Plasma Redox Balance in Advanced-Maternal-Age Pregnant Women and Effects of Plasma on Umbilical Cord Mesenchymal Stem Cells

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