Oxygen Consumption Correlated With the Thermal Reactions of Young Rats to Ergotoxine

Roberts, James E.; Robinson, Benjamin E.; Buchanan, A. R.

doi:10.1152/ajplegacy.1949.156.2.170

Cited by 5 publications

(6 citation statements)

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“…Further studies are needed to compare the responses of rats and cattle to ergovaline under these conditions. 16-day-old Wistar rats injected with ergotoxine a t 28-32 "C, with a concomitant change in rectal temperature (Roberts et al, 1949).…”

Section: Resultsmentioning

confidence: 99%

“…Although it has never been reported that EV injection (ip) decreases rectal temperature in rats a t thermoneutrality (22 "C), Neal and Schmidt (1985) noted that rats fed 50% endophyte-infected seed in the diet for 15 days exhibited a significant reduction in rectal temperature from 37.7 to 36.8 "C over ambient temperatures ranging from 24 to 32 "C. Intravenous ergopeptine administration (0.26 and 0.46 mg/kg) in rabbits decreased rectal temperature 0.5 and 1 "C, respectively (Loew et al, 1978). Roberts et al (1949) reported that hypothermic response to ergotoxine in young Wistar rats (28 "C ambient temperature) was associated with decreased oxygen consumption, with no explanation of response mechanisms. Loew et al (1978) suggested that ergot alkaloid-induced hypothermia is mediated by either peripheral or central a-adrenergic blockade.…”

Section: Resultsmentioning

confidence: 99%

“…Intravenous ergopeptine administration (0.26 and 0.46 mg/kg) in rabbits decreased rectal temperature 0.5 and 1 °C, respectively (Loew et al, 1978). Roberts et al (1949) reported that hypothermic response to ergotoxine in young Wistar rats (28 °C ambient temperature) was associated with decreased oxygen consumption, with no explanation of response mechanisms. Loew et al (1978) suggested that ergot alkaloid-induced hypothermia is mediated by either peripheral or central -adrenergic blockade.…”

Section: Resultsmentioning

confidence: 99%

“…Loew et al (1978) suggested that ergot alkaloid-induced hypothermia is mediated by either peripheral or central -adrenergic blockade. Roberts et al (1949) suspected hypothermia may be due to unselective inhibition/stimulation of heat-production and heat-loss centers, with the latter predominating in young rats after ergot alkaloid injection. This could be the reason for the rapid reduction in body temperature in rats.…”

Section: Resultsmentioning

confidence: 99%

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Thermoregulatory Effects of Ergovaline Isolated from Endophyte-Infected Tall Fescue Seed on Rats

Zhang¹,

Spiers²,

Rottinghaus³

et al. 1994

J. Agric. Food Chem.

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Ergovaline (EV) was isolated from Acremonium coenophialum-infected tall fescue seed. Seed (2 kg) was extracted with 20 L of 5% lactic acid in water/methanol(4:1), filtered, and passed over an Amberlite XAD-2 column. Ergovaline was eluted with MeOH, concentrated, and chromatographed on two reversedphase C18 columns (purity > 95%, 40% overall recovery). It was administered to rats (15 pg/kg of BW, ip) a t 22 "C to determine time-related acute effects on thermoregulatory ability. Rectal temperature in EV-treated rats decreased 1.6 O C by 50 min (p 5 0.05), due to reduction in heat production ( p 5 0.05) and increase in heat loss across the tail ( p I 0.05) a t 10-20 min postinjection. This study provides a rapid, economical method for milligram-scale isolation of ergovaline and defines the thermoregulatory mechanisms responsible for ergovaline-induced hypothermia under nonstress conditions.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Thermoregulatory Effects of Ergovaline Isolated from Endophyte-Infected Tall Fescue Seed on Rats

Zhang¹,

Spiers²,

Rottinghaus³

et al. 1994

J. Agric. Food Chem.

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“…This was demonstrated initially using classical biomedical animal models. In an early study, Roberts et al (1949) injected rats intraperitoneally with ergotoxine (4.5 mg/kg BW) at Tir = 28 to 30°C. The rats were tested at ages 12 d (juvenile) and 37 d (adult) and exhibited hypothermic and hyperthermic responses, respectively.…”

Section: Thermal Response Heat Tolerance and Stressmentioning

confidence: 99%

Physiological Basis of Fescue Toxicosis

Strickland

Aiken

Spiers

et al. 2015

Agronomy Monographs

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Tall fescue toxicosis continues to be a major syndrome in temperate climates of the world in terms of economic loss to animal producers. Studies with forage-fed animals over the past three decades have provided insight concerning the pathophysiological effects of the alkaloids present in tall fescue [Lolium arundinaceum (Schreb.) DarbyshJ infected with the fungal endophyte Neotyphodium coenophialum (Morgan-Jones and Gams) Glenn, Bacon, and Hanlin. To provide the reader a general understanding of the overall problem, we present a detailed discussion of the clinical signs of fescue toxicosis, the proposed toxicants, and projected solutions to this costly disease condition of ungulates. We also explore the physiological mechanisms proposed to be involved in the expression of the syndrome. Finally, we offer our suggestions for future research efforts in this arena and the potential impact of these approaches. T all fescue is an economically important cool-season perennial forage grass covering about 15 million ha in the United States alone (Buckner et al., 1979) and many more in continents outside North America (see Chapter 3, Hannaway et alv 2009, this publication). The vast majority of the tall fescue in the United States is grown within the transition zone of the eastern and central part of the country. With the development of novel nontoxic endophytes, tall fescue is again becoming increasingly popular for pastures in New Zealand and Australia. The wide distribution of tall fescue has been attributed to its symbiotic relationship (see Chapter 14, Christensen and Voisey, 2009, this publication) with the endophytic fungus Neotyphodium coenophialum (Glenn et al., 1996). Although beneficial to

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Interaction Between Thermal Stress and Fescue Toxicosis: Animal Models and New Perspectives

Spiers

Evans

Rottinghaus

2005

Neotyphodium in Cool‐Season Grasses

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Oxygen Consumption Correlated With the Thermal Reactions of Young Rats to Ergotoxine

Cited by 5 publications

References 0 publications

Thermoregulatory Effects of Ergovaline Isolated from Endophyte-Infected Tall Fescue Seed on Rats

Thermoregulatory Effects of Ergovaline Isolated from Endophyte-Infected Tall Fescue Seed on Rats

Physiological Basis of Fescue Toxicosis

Interaction Between Thermal Stress and Fescue Toxicosis: Animal Models and New Perspectives

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