Oxygen cycling to improve survival of stem cells for myocardial repair: A review

Dall, Christopher; Khan, Mahmood; Angelos, Mark G.

doi:10.1016/j.lfs.2016.04.011

Cited by 13 publications

(13 citation statements)

References 82 publications

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“…Numerous studies have proven that preconditioning at low oxygen levels can stimulate intrinsic cell defense mechanisms, leading to improved cell survival and positive effects on SC efficiency [394,418,419]. For example, CDC sheets subjected to hypoxic conditions markedly increase angiogenesis by 25% in the infarction border zone and significantly reduce collagen deposition in mice [420].…”

Section: Cellular Physiology and Biochemistrymentioning

confidence: 99%

Stem Cell Therapy in Heart Diseases – Cell Types, Mechanisms and Improvement Strategies

Müller

Lemcke

Dávid

2018

Cell Physiol Biochem

174

140

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A large number of clinical trials have shown stem cell therapy to be a promising therapeutic approach for the treatment of cardiovascular diseases. Since the first transplantation into human patients, several stem cell types have been applied in this field, including bone marrow derived stem cells, cardiac progenitors as well as embryonic stem cells and their derivatives. However, results obtained from clinical studies are inconsistent and stem cell-based improvement of heart performance and cardiac remodeling was found to be quite limited. In order to optimize stem cell efficiency, it is crucial to elucidate the underlying mechanisms mediating the beneficial effects of stem cell transplantation. Based on these mechanisms, researchers have developed different improvement strategies to boost the potency of stem cell repair and to generate the “next generation” of stem cell therapeutics. Moreover, since cardiovascular diseases are complex disorders including several disease patterns and pathologic mechanisms it may be difficult to provide a uniform therapeutic intervention for all subgroups of patients. Therefore, future strategies should aim at more personalized SC therapies in which individual disease parameters influence the selection of optimal cell type, dosage and delivery approach.

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Section: Cellular Physiology and Biochemistrymentioning

confidence: 99%

Stem Cell Therapy in Heart Diseases – Cell Types, Mechanisms and Improvement Strategies

Müller

Lemcke

Dávid

2018

Cell Physiol Biochem

174

140

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“…Low oxygen levels, deprived nutrient supply, oxidative stress, and inflammatory mediators impede successful engraftment and lead to cell death early after transplantation [ 95 ]. Hypoxic priming of SC prior to transplantation was found to stimulate endogenous cell defense mechanisms, thereby increasing cell survival and improving the beneficial effects of SC therapy [ 96 – 98 ]. In numerous preclinical studies, duration of hypoxia varied from hours to days, while the level of hypoxia commonly ranged between 0.5% and 3% [ 96 , 99 ].…”

Section: Strategies To Improve Cell Therapeuticsmentioning

confidence: 99%

Recent Progress in Stem Cell Modification for Cardiac Regeneration

Lemcke

Voronina

Steinhoff

et al. 2018

Stem Cells International

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During the past decades, stem cell-based therapy has acquired a promising role in regenerative medicine. The application of novel cell therapeutics for the treatment of cardiovascular diseases could potentially achieve the ambitious aim of effective cardiac regeneration. Despite the highly positive results from preclinical studies, data from phase I/II clinical trials are inconsistent and the improvement of cardiac remodeling and heart performance was found to be quite limited. The major issues which cardiac stem cell therapy is facing include inefficient cell delivery to the site of injury, accompanied by low cell retention and weak effectiveness of remaining stem cells in tissue regeneration. According to preclinical and clinical studies, various stem cells (adult stem cells, embryonic stem cells, and induced pluripotent stem cells) represent the most promising cell types so far. Beside the selection of the appropriate cell type, researchers have developed several strategies to produce “second-generation” stem cell products with improved regenerative capacity. Genetic and nongenetic modifications, chemical and physical preconditioning, and the application of biomaterials were found to significantly enhance the regenerative capacity of transplanted stem cells. In this review, we will give an overview of the recent developments in stem cell engineering with the goal to facilitate stem cell delivery and to promote their cardiac regenerative activity.

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“…It is increasingly recognised that some stem cells that are considered quiescent can be more easily “activated” by exposure to physiologically low oxygen levels, as demonstrated for muscle stem cells extracted from old muscles and “senescent” adipogenic precursor cells . Hypoxia conditioning has been suggested to improve the stem cell survival and enhance myocardial regeneration (reviewed in Dall et al), with cardiomyocyte activation and cycling in vivo strongly associated with hypoxia signalling . Furthermore, after experimental myocardial infarction, exposure to severe systemic hypoxaemia induces metabolic reprogramming of adult cardiomyocytes, resulting in cell cycle re‐entry, reactivation of cardiomyocyte mitosis and improved heart regeneration .…”

Section: Part A: Major Advances In Tissue Culture For Bioengineering:mentioning

confidence: 99%

Obstacles and challenges for tissue engineering and regenerative medicine: Australian nuances

Grounds

2018

Clin Exp Pharma Physio

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The clinical need and historical approaches to tissue engineering as applied to regenerative medicine are introduced, along with comments on activities in this field around Australia, and then the huge advances for tissue culture studies are discussed (Part A). Combinations of human stem cells and new approaches for generating bioscaffolds present great opportunities for in vitro studies of basic biology and physiology, drug testing and high throughput screening for the pharmaceutical industry, and the advanced tissue engineering of organs and devices. The future here is bright. The major obstacles arise with in vivo application of these bioengineering advances using animal models and humans (Part B), and the complexity of living tissues and the challenges of increased scale required for clinical translation to the large human situation are first discussed. While clinical success seen with implantation of acellular bioscaffolds (with population by host cells) is likely to expand for human use, the major challenge relates to (generally) low survival in vivo of (donor or autologous) cells that are expanded and grown in tissue culture before implantation into the living body. Another major challenge is revascularisation of implanted tissues/organs at the human scale. The innovative approaches and rapid advances in tissue bioengineering hold great promise for overcoming these major obstacles and extending the clinical applications of these technologies.

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Oxygen cycling to improve survival of stem cells for myocardial repair: A review

Cited by 13 publications

References 82 publications

Stem Cell Therapy in Heart Diseases – Cell Types, Mechanisms and Improvement Strategies

Stem Cell Therapy in Heart Diseases – Cell Types, Mechanisms and Improvement Strategies

Recent Progress in Stem Cell Modification for Cardiac Regeneration

Obstacles and challenges for tissue engineering and regenerative medicine: Australian nuances

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