2021
DOI: 10.1002/viw.20200139
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Oxygen‐derived free radicals: Production, biological importance, bioimaging, and analytical detection with responsive luminescent nanoprobes

Abstract: Oxygen-derived free radicals (ODFRs) are partially reduced oxygen reactive intermediates in living organisms during various biological processes, such as mitochondrial respirations, enzyme-catalyzed oxidations, and radiolysis. Of various ODFRs being identified, superoxide anion (O 2•-) and hydroxyl (•OH) radicals are extensively investigated. Due to their high reactivity, these radicals can oxidize many biomolecules, including nucleic acids, proteins, lipids, and carbohydrates, which would damage some key cell… Show more

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Cited by 22 publications
(11 citation statements)
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“…These biomolecules play very important roles in biological systems [25,27,161]. For example, ROS/RNS are important signaling molecules in the body, while high levels of ROS/RNS lead to oxidative stress, causing damage to the cell membrane, protein and nucleic acids [162]. It has been reported that the overexpression of ROS/RNS is implicated in pathological processes in inflammation, cancer, cardiovascular disease, Alzheimer's disease (AD) and aging [162,163].…”
Section: Ru(ii) Complex Chemosensors For Reactive Biomoleculesmentioning
confidence: 99%
See 3 more Smart Citations
“…These biomolecules play very important roles in biological systems [25,27,161]. For example, ROS/RNS are important signaling molecules in the body, while high levels of ROS/RNS lead to oxidative stress, causing damage to the cell membrane, protein and nucleic acids [162]. It has been reported that the overexpression of ROS/RNS is implicated in pathological processes in inflammation, cancer, cardiovascular disease, Alzheimer's disease (AD) and aging [162,163].…”
Section: Ru(ii) Complex Chemosensors For Reactive Biomoleculesmentioning
confidence: 99%
“…For example, ROS/RNS are important signaling molecules in the body, while high levels of ROS/RNS lead to oxidative stress, causing damage to the cell membrane, protein and nucleic acids [162]. It has been reported that the overexpression of ROS/RNS is implicated in pathological processes in inflammation, cancer, cardiovascular disease, Alzheimer's disease (AD) and aging [162,163]. Nevertheless, determination and monitoring their levels in situ remain a challenge due to (1) the limited numbers of robust chemosensors and (2) their high reactivity and the short lifetime of Fig.…”
Section: Ru(ii) Complex Chemosensors For Reactive Biomoleculesmentioning
confidence: 99%
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“…On the other hand, the easy-tooperate PL signal guarantee a low expansive, real-time, in situ analysis. Finally, the mimic behavior of the nanoprobes into the living cell benefits from the non-invasiveness proper of the biomolecules (Liu et al, 2021). As will be discussed in the next section, the tailored composition of nanosized hybrid probes can represent a value-added in the design of the new generation of PL smart tools.…”
Section: Luminescent Nanomaterials For Biological Target Sensingmentioning
confidence: 99%