Oxygen-enhanced Magnetic Resonance Imaging versus Computed Tomography

Ohno, Yoshiharu; Iwasawa, Tae; Seo, Joom Beom; Koyama, Hisanobu; Takahashi, Hiroshi; Oh, Yeon‐Mok; Nishimura, Yoshihiro; Sugimura, Kazuro

doi:10.1164/rccm.200709-1322oc

Cited by 88 publications

(33 citation statements)

References 46 publications

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“…The frequency and spatial extent of signal alterations detected by T1 mapping, oxygen-enhanced T1 mapping and perfusion abnormalities increased from mild to severe COPD, and each showed a moderate agreement with GOLD stage. Despite using a different approach (dynamic oxygen-enhanced MRI delivering relative signal changes) in a prospective multi-center trial, Ohno et al also reported a significant association between the mean relative enhancement ratio during supplementation of 100% oxygen and air flow limitation (FEV1%) in 160 smokers [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Functional Lung MRI in Chronic Obstructive Pulmonary Disease: Comparison of T1 Mapping, Oxygen-Enhanced T1 Mapping and Dynamic Contrast Enhanced Perfusion

Jobst

Triphan²,

Sedlaczek

et al. 2015

PLoS ONE

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PurposeMonitoring of regional lung function in interventional COPD trials requires alternative endpoints beyond global parameters such as FEV1. T1 relaxation times of the lung might allow to draw conclusions on tissue composition, blood volume and oxygen fraction. The aim of this study was to evaluate the potential value of lung Magnetic resonance imaging (MRI) with native and oxygen-enhanced T1 mapping for the assessment of COPD patients in comparison with contrast enhanced perfusion MRI.Materials and Methods20 COPD patients (GOLD I-IV) underwent a coronal 2-dimensional inversion recovery snapshot flash sequence (8 slices/lung) at room air and during inhalation of pure oxygen, as well as dynamic contrast-enhanced first-pass perfusion imaging. Regional distribution of T1 at room air (T1), oxygen-induced T1 shortening (ΔT1) and peak enhancement were rated by 2 chest radiologists in consensus using a semi-quantitative 3-point scale in a zone-based approach.ResultsAbnormal T1 and ΔT1 were highly prevalent in the patient cohort. T1 and ΔT1 correlated positively with perfusion abnormalities (r = 0.81 and r = 0.80; p&0.001), and with each other (r = 0.80; p<0.001). In GOLD stages I and II ΔT1 was normal in 16/29 lung zones with mildly abnormal perfusion (15/16 with abnormal T1). The extent of T1 (r = 0.45; p<0.05), ΔT1 (r = 0.52; p<0.05) and perfusion abnormalities (r = 0.52; p<0.05) showed a moderate correlation with GOLD stage.ConclusionNative and oxygen-enhanced T1 mapping correlated with lung perfusion deficits and severity of COPD. Under the assumption that T1 at room air correlates with the regional pulmonary blood pool and that oxygen-enhanced T1 reflects lung ventilation, both techniques in combination are principally suitable to characterize ventilation-perfusion imbalance. This appears valuable for the assessment of regional lung characteristics in COPD trials without administration of i.v. contrast.

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Section: Discussionmentioning

confidence: 99%

Functional Lung MRI in Chronic Obstructive Pulmonary Disease: Comparison of T1 Mapping, Oxygen-Enhanced T1 Mapping and Dynamic Contrast Enhanced Perfusion

Jobst

Triphan²,

Sedlaczek

et al. 2015

PLoS ONE

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“…84,85 The approach consists in detecting modulations of lung parenchymal proton signals induced by changes in oxygenation levels. 86 Oxygenenhanced MRI has been further explored clinically in smoking-induced COPD patients 87,88 and in asthmatics. 89 Ohno et al 88 showed recently in a large cohort of individuals that dynamic O 2 -enhanced MRI is as efficacious as thin-section multidetector-row CT to quantify COPD-related changes in patients (Figure 17.7).…”

Section: Ventilationmentioning

confidence: 99%

CHAPTER 17. Magnetic Resonance Imaging in Respiratory Diseases: From Diagnosis to Pharmaceutical Research and Development

Beckmann¹,

Egger²,

Crémillieux³

2013

New Developments in NMR

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“…There have been substantial advances in functional pulmonary MRI in the last few decades from imaging gases dominated by polarized noble gases and from tissue MRI, notably from the effect of breathing pure oxygen on the tissue T 1 . The present study is anatomical in comparison.…”

Section: Introductionmentioning

confidence: 96%

“…21 There have been substantial advances in functional pulmonary MRI in the last few decades from imaging gases 24 dominated by polarized noble gases [25][26][27][28][29][30][31] and from tissue MRI, notably from the effect of breathing pure oxygen on the tissue T 1 . [32][33][34][35][36][37][38][39][40] The present study is anatomical in comparison. We want good images of the tissue and pathologies themselves (s.s., the protons therein).…”

Section: Introductionmentioning

confidence: 99%

T₁, T₁ contrast, and Ernst‐angle images of four rat‐lung pathologies

Kuethe

Hix

Fredenburgh

2018

Magnetic Resonance in Med

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Purpose To initiate the archive of relaxation‐weighted images that may help discriminate between pulmonary pathologies relevant to acute respiratory distress syndrome. MRI has the ability to distinguish pathologies by providing a variety of different contrast mechanisms. Lungs have historically been difficult to image with MRI but image quality is sufficient to begin cataloging the appearance of pathologies in T1‐ and T2‐weighted images. This study documents T1 and the use of T1 contrast with four experimental rat lung pathologies. Methods Inversion‐recovery and spoiled steady state images were made at 1.89 T to measure T1 and document contrast in rats with atelectasis, lipopolysaccharide‐induced inflammation, ventilator‐induced lung injury (VILI), and injury from saline lavage. Higher‐resolution Ernst‐angle images were made to see patterns of lung infiltrations. Results T1‐weighted images showed minimal contrast between pathologies, similar to T1‐weighted images of other soft tissues. Images taken shortly after magnetization inversion and displayed with inverted contrast highlight lung pathologies. Ernst‐angle images distinguish the effects of T1 relaxation and spin density and display distinctive patterns. T1 for pathologies were: atelectasis, 1.25 ± 0.046 s; inflammation from instillation of lipopolysaccharide, 1.24 ± 0.015 s; VILI, 1.55 ± 0.064 s (p = 0.0022 vs. normal lung); and injury from saline lavage, 1.90±0.080 s (p = 0.0022 vs. normal lung; p = 0.0079 vs. VILI). T1 of normal lung and erector spinae muscle were 1.25 ± 0.028 s and 1.02 ± 0.027 s, respectively (p = 0.0022). Conclusions Traditional T1‐weighting is subtle. However, images made with inverted magnetization and inverted contrast highlight the pathologies and Ernst‐angle images aid in distinguishing pathologies.

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Oxygen-enhanced Magnetic Resonance Imaging versus Computed Tomography

Abstract: O(2)-enhanced MRI is effective for pulmonary functional loss assessment and clinical stage classification of smoking-related COPD and quantitative CT.

Cited by 88 publications

References 46 publications

Functional Lung MRI in Chronic Obstructive Pulmonary Disease: Comparison of T1 Mapping, Oxygen-Enhanced T1 Mapping and Dynamic Contrast Enhanced Perfusion

Functional Lung MRI in Chronic Obstructive Pulmonary Disease: Comparison of T1 Mapping, Oxygen-Enhanced T1 Mapping and Dynamic Contrast Enhanced Perfusion

CHAPTER 17. Magnetic Resonance Imaging in Respiratory Diseases: From Diagnosis to Pharmaceutical Research and Development

T₁, T₁ contrast, and Ernst‐angle images of four rat‐lung pathologies

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Oxygen-enhanced Magnetic Resonance Imaging versus Computed Tomography

Abstract: O(2)-enhanced MRI is effective for pulmonary functional loss assessment and clinical stage classification of smoking-related COPD and quantitative CT.

Cited by 88 publications

References 46 publications

Functional Lung MRI in Chronic Obstructive Pulmonary Disease: Comparison of T1 Mapping, Oxygen-Enhanced T1 Mapping and Dynamic Contrast Enhanced Perfusion

Functional Lung MRI in Chronic Obstructive Pulmonary Disease: Comparison of T1 Mapping, Oxygen-Enhanced T1 Mapping and Dynamic Contrast Enhanced Perfusion

CHAPTER 17. Magnetic Resonance Imaging in Respiratory Diseases: From Diagnosis to Pharmaceutical Research and Development

T1, T1 contrast, and Ernst‐angle images of four rat‐lung pathologies

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T₁, T₁ contrast, and Ernst‐angle images of four rat‐lung pathologies