Oxygen-enriched oleic matrix (NovoX) for wound healing in pediatric patients undergoing open surgical treatment for pilonidal disease: Preliminary experience

Abstract

IntroductionPilonidal disease (PD) is a common infectious and inflammatory condition affecting the gluteal cleft and sacrococcygeal region. The optimal treatment for PD remains controversial. While the open technique reduces the number of relapses compared to minimally invasive approaches, it is associated with a longer healing time. Reactive oxygen species are a key part of the normal wound-healing process. Herein, we reported our preliminary experience using a new oxygen-enriched oil-based product called NovoX for wound healing after open surgery for PD.Materials and methodsWe used a new oxygen-enriched product for wound healing in three pediatric patients undergoing open surgical repair for PD between December 2021 and April 2022. During postoperative follow-up, healing time and the aesthetic result were evaluated.ResultsOur preliminary study included three patients with chronic PD. The average follow-up time was 5 weeks, corresponding to the end of the healing process and the resumption of normal daily activities. Only one mild complication occurred during the study period. No short-term side effects were reported. The cosmetic result was reported as satisfactory.ConclusionNovoX is easy to apply, safe, and effective for treating pediatric patients undergoing open surgical treatment for PD, leading to slightly faster wound healing with good aesthetic outcomes.

Paediatric Pilonidal Sinus Disease: Early Recurrences Irrespective of the Treatment Approaches in a Retrospective Multi‐centric Analysis

“…National guidelines were developed in Italy [7], the USA [8], and Germany [9], but seldom mentioned children and adolescents specifically. The literature is divided on the procedure of choice for paediatric pilonidal sinus disease: Some favour resection and primary midline closure [10][11][12][13], others excision and open wound treatment [14,15], endoscopic [16,17], minimally invasive [18][19][20] or flap procedures [21,22]. Despite these numerous reports on a variety of treatment approaches, none of them was determined to be advantageous in a systematic review of surgical approaches to paediatric pilonidal sinus disease [23].…”

Ultrasound in paediatric surgery: A meta‐analysis review of its influence on postoperative wound healing and infection rates

“…The antiinflammatory and microcirculatory benefits of US might play a role in creating an environment less conducive for microbial proliferation. 7 Despite these promising insights, a comprehensive understanding of the therapeutic potential of US in postoperative wound healing and infection prevention, particularly in paediatric surgeries, remains elusive. This meta-analysis aims to bridge this knowledge gap, offering a holistic review of the impact of US on postoperative outcomes in paediatric patients.…”

“…The anti‐inflammatory and microcirculatory benefits of US might play a role in creating an environment less conducive for microbial proliferation. 7 …”

“…Infections, particularly deep wound infections after major surgeries, pose significant challenges in paediatric care. The anti‐inflammatory and microcirculatory benefits of US might play a role in creating an environment less conducive for microbial proliferation 7 …”