Oxygen exchange mechanisms in the human placenta: mathematical modelling and simulation

Costa, Andrea; Costantino, Maria Laura; Fumero, R.

doi:10.1016/0141-5425(92)90083-w

Cited by 14 publications

(8 citation statements)

References 5 publications

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“…Most modelling studies in the past have focused mainly on blood flow, water exchange or oxygen and carbon dioxide transfer between mother and fetus (Wilbur et al 1978; Schröder, 1982; Groome, 1991; Sebire et al 2004). Models have either evaluated spatial flow patterns (Erian et al 1977; Schmid‐Schönbein, 1988) or focused on the scale of a single capillary (Guilbeau et al 1973; Costa et al 1992). An excellent comprehensive overview of these modelling approaches has been compiled by Chernyavsky et al (2010).…”

mentioning

confidence: 99%

Computational modelling of amino acid transfer interactions in the placenta

Sengers

Please

Lewis

2010

Experimental Physiology

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Amino acid transfer from mother to fetus via the placenta plays a critical role in normal development, and restricted transfer is associated with fetal growth restriction. Placental amino acid transfer involves the interaction of 15 or more transporters and 20 amino acids. This complexity means that knowing which transporters are present is not sufficient to predict how they operate together as a system. Therefore, in order to investigate how placental amino acid transfer occurs as a system, an integrated mathematical/computational modelling framework was developed to represent the simultaneous transport of multiple amino acids. The approach was based on a compartmental model, in which separate maternal, syncytiotrophoblast and fetal volumes were distinguished, and transporters were modelled on the maternal-and fetal-facing membranes of the syncytiotrophoblast using Michaelis-Menten-type kinetics. The model was tested in comparison with placental perfusion experiments studying serine-alanine exchange and found to correspond well. The results demonstrated how the different transporters can work together as an integrated system and allowed their relative importance to be assessed. Placental-fetal serine exchange was found to be most sensitive to basal membrane transporter characteristics, but a range of secondary, less intuitive effects were also revealed. While this work only addressed a relatively simple three amino acid system, it demonstrates the feasibility of the approach and could be extended to incorporate additional experimental parameters. Ultimately, this approach will allow physiological simulations of amino acid transfer. This will enhance our understanding of these complex systems and placental function in health and disease.

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confidence: 99%

Computational modelling of amino acid transfer interactions in the placenta

Sengers

Please

Lewis

2010

Experimental Physiology

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“…(b)Parametric model of a dichotomous branching in the chorionic arteries [57]. (c)One-dimensional model of a placental transport unit [58]. (d)Three-dimensional CLSM based model of a terminal villi with flow streamlines [mm/s] [59].…”

Section: Maternal and Fetal Blood Flowsmentioning

confidence: 99%

“…The outcome was then coupled with a complete fetal circulatory system. A simpler approach is to model terminal villi blood flow as a 1D fluid [58]. With the aim of understanding the oxygen mechanisms during the second trimester, where data are scarce, Costa etal.…”

Section: Maternal and Fetal Blood Flowsmentioning

confidence: 99%

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Advances in Human Placental Biomechanics

Mayo

2018

Computational and Structural Biotechnology Journal

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Pregnancy complications are a major clinical concern due to the related maternal and fetal morbidity. Many are caused through defective placentation, but research into placental function is difficult, principally because of the ethical limitations associated with the in-vivo organ and the difficulty of extrapolating animal models. Perfused by two separate circulations, the maternal and fetal bloodstreams, the placenta has a unique structure and performs multiple complex functions. Three-dimensional imaging and computational modelling are becoming popular tools to investigate the morphology and physiology of this organ. These techniques bear the potential for better understanding the aetiology and development of placental pathologies, however, their full potential is yet to be exploited. This review aims to summarize the recent insights into placental structure and function by employing these novel techniques.

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“…Some are based on fetal lamb circulation [30]. Some addresses fetoplacental circulation [31,32] while some addresses arterial system [33,34]. Some are based on lumped parameter model analogous to electrical circuits [35][36][37].…”

Section: Introductionmentioning

confidence: 99%

Simulation and Analysis of Umbilical Blood Flow using Markov-based Mathematical Model

Queyam¹,

Pahuja²,

Singh³

2017

IJISA

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Abstract-The intra-uterine development of the fetus depends on various factors, one such critical factor is umbilical blood flow because the quantity of oxygen delivered to the placenta and to the fetus is directly limited by umbilical blood flow rate. Since the measurement of the hemodynamic quantities such as blood pressure and blood flow rate is not possible in utero hence the use of patient-specific mathematical modeling is beneficial for the assessment of feto-maternal wellbeing. A Markov model based mathematical model of fetal circulation is developed by taking three node concept. The fetus, the umbilical cord, and the placenta represent the 3 nodes of Markov model. A LabVIEWbased virtual instrument is designed to simulate the mathematical model which results in waveform similar to Doppler blood flow velocimetry of umbilical artery. The model is simulated at various degree of conductivity of the umbilical cord to the oxygenated blood. Simulation results show that the umbilical artery blood flow velocity waveform depends on gestation age, fetal heart rate, uterine contraction and placental insufficiency. The Doppler indices calculated from simulation helps in predicting both fetal and maternal abnormalities at various degrees of the conductivity to the blood flow passage. Therefore, integrating patient-specific models along with established medical equipments will be helpful in identifying true intra-uterine growth restricted fetuses from normal fetuses and helps clinicians to take timely interventions.

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Oxygen exchange mechanisms in the human placenta: mathematical modelling and simulation

Cited by 14 publications

References 5 publications

Computational modelling of amino acid transfer interactions in the placenta

Computational modelling of amino acid transfer interactions in the placenta

Advances in Human Placental Biomechanics

Simulation and Analysis of Umbilical Blood Flow using Markov-based Mathematical Model

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