Oxygen free radicals and antioxidants in cystic fibrosis: the concept of an oxidant‐antioxidant imbalance

Winklhofer‐Roob, Brigitte M.

doi:10.1111/j.1651-2227.1994.tb13229.x

Cited by 95 publications

(69 citation statements)

References 67 publications

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“…7 In this study, all patients were regularly supplemented with vitamin A and those with severe fibrosis or cirrhosis at biopsy had serum levels of retinol similar to those in matched control patients with CF without liver disease (data not shown). Lipid peroxidation might influence the development of liver disease, [42][43][44] but the patients with severe fibrosis or cirrhosis had serum levels of ␣-tocopherol within the normal reference interval and did not differ from patients with CF without liver disease (data not shown). Similar to other studies, we found no correlation among liver disease and lung function or bacterial colonization, implying that bacterial toxin production had no great impact on liver damage.…”

Section: Discussionmentioning

confidence: 99%

Natural history of liver disease in cystic fibrosis

1999

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The median age of the population with cystic fibrosis (CF) has increased worldwide, which has led to the suggestion that the prevalence of liver disease would increase. The aim of this study was to evaluate the natural history of CF‐associated liver disease over a 15‐year period in a well‐controlled population of patients with CF. During the years 1976 through 1993, 124 patients were followed up by yearly liver function tests (LFTs). Fifteen patients were followed up with liver biopsies throughout the whole study period. More than 50% of the patients had pathological LFTs in infancy, later being normalized. Approximately 25% of children 4 years of age or older had biochemical markers of liver disease during the study period. In about 10% of the patients, cirrhosis or advanced fibrosis was confirmed at biopsy and 4% of patients had cirrhosis with clinical liver disease. Severe liver disease developed mainly during prepuberty and puberty. Of the 15 patients prospectively followed up with liver biopsies, only 3 had progressive fibrosis. No specific risk factor was identified, but deficiency of essential fatty acids was found more often in patients with marked steatosis (P < .05). No patient developed clinical liver disease in adulthood and the histological changes in the liver biopsies were usually not progressive. Liver disease was no more frequent at the end of the study period although the median age of the patient population had increased. Modern treatment might positively influence liver disease because it seemed less common, less progressive, and less serious than previously reported.

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Section: Discussionmentioning

confidence: 99%

Natural history of liver disease in cystic fibrosis

1999

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“…Lipid peroxidation products e.g. malondialdehyde has been taken as a biomarker for oxidative stress in biological system [20,22] . This circumstance can lead to 'oxidative stress' i.e.…”

Section: Discussionmentioning

confidence: 99%

Effects of Computer Use on Human Salivary Oxidant/Antioxidant Status

Ergüder¹,

Durak²

2006

OnLine J. of Biological Sciences

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Abstract:Computers are widely used in recent years but their effects on human health completely are known. The aim of this study was to investigate possible effects of computer use on human salivary oxidant / antioxidant system. Ten subjects were included in the study. Three saliva samples were taken from the subjects. First was obtained before computer use, second and third samples were obtained two and four hours after they started computer use. Malondialdehyde (MDA) levels and superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and adenosine deaminase (ADA) enzyme activities were measured in each saliva sample. Malondialdehyde (MDA) level (mean ± standard deviation) was found to increase in the saliva samples obtained after computer use. SOD and ADA activities decreased but, CAT activity increased during this period. Our results show that computer-released radiation causes changes in enzymatic antioxidant defense system and, leads to oxidant stress in saliva samples from subjects. It has been suggested that subjects who use computer intensively should be consumed more antioxidant foods in order to prevent probable oxidation reactions in their bodies.

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“…Activated neutrophils and macrophages are major sources of oxygen free radicals including hydrogen peroxide (H 2 O 2 ). Indeed, lung infection in CF leads to increased oxygen free radical generation [7,8]. Furthermore, sputum of CF-patients has been shown to prime neutrophils towards enhanced release of oxygen radicals [9].…”

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confidence: 99%

Hydrogen peroxide and nitric oxide in exhaled air of children with cystic fibrosis during antibiotic treatment

Jöbsis

Raatgeep²,

Schellekens³

et al. 2000

Eur Respir J

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Cystic fibrosis (CF) patients characteristically have severe chronic airway inflammation associated with bacterial infection. A noninvasive marker of airway inflammation could be a useful guide to treatment of CF lung disease. The aim of this study was to assess whether measurement of hydrogen peroxide (H2O2) and nitric oxide (NO) in exhaled air can serve to monitor the effect of treatment with antibiotics in CF‐children with acute infective pulmonary exacerbations. Sixteen CF‐patients (mean age 12.3 yrs) with exacerbation of their lung infection were treated with intravenous antibiotics in an uncontrolled study. During treatment, H2O2 in exhaled air condensate was measured twice a week. In addition, serial NO measurements were performed in nine patients. During antibiotic treatment the median H2O2 concentration in exhaled air condensate decreased significantly from 0.28 µM (range 0.07–1.20 µM) to 0.16 µM (range 0.05–0.24 µM, p=0.002) and the mean forced expiratory volume in one second significantly increased from 55% predicted to 75% pred (p=0.001). In individual subjects, changes of H2O2 and FEV1 between pairs of serial measurements correlated weakly (p=0.08). Data on exhaled NO were inconclusive; exhaled NO did not change systematically during treatment. It is concluded that cystic fibrosis patients with an acute pulmonary exacerbation have abnormally high concentrations of hydrogen peroxide, but not of nitric oxide, in exhaled air, which decrease during intravenous antibiotic treatment. Further controlled studies should establish if exhaled hydrogen peroxide, may serve as a noninvasive parameter of airway inflammation to guide antibiotic treatment in cystic fibrosis lung disease.

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Oxygen free radicals and antioxidants in cystic fibrosis: the concept of an oxidant‐antioxidant imbalance

Cited by 95 publications

References 67 publications

Natural history of liver disease in cystic fibrosis

Natural history of liver disease in cystic fibrosis

Effects of Computer Use on Human Salivary Oxidant/Antioxidant Status

Hydrogen peroxide and nitric oxide in exhaled air of children with cystic fibrosis during antibiotic treatment

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